Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase β

N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA

(2015) Yi Kou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes

(2015) Isaac J. Kimsey et al.   NATURE

Metal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase β

(2014) Myong-Chul Koag et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β

(2014) Myong-Chul Koag et al.   NUCLEIC ACIDS RESEARCH

Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine

(2014) Myong-Chul Koag et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanistic studies of polymerase   bypass of phenanthriplatin DNA damage

(2014) M. T. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Observing a DNA Polymerase Choose Right from Wrong

(2013) Bret D. Freudenthal et al.   CELL

The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation

(2013) Patricia Garrido et al.   NUCLEIC ACIDS RESEARCH

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase  

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Minor Groove Hydrogen Bonding Interactions between RB69 DNA Polymerase and DNA

(2012) Shuangluo Xia et al.   BIOCHEMISTRY

DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase

(2012) Shuangluo Xia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

(2012) Bret D. Freudenthal et al.   NUCLEIC ACIDS RESEARCH

Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

(2012) Bret D. Freudenthal et al.   STRUCTURE

The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an “Ajar” Intermediate Conformation in the Nucleotide Selection Mechanism

(2011) Eugene Y. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication infidelity via a mismatch with Watson–Crick geometry

(2011) Katarzyna Bebenek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binary complex crystal structure of DNA polymerase   reveals multiple conformations of the templating 8-oxoguanine lesion

(2011) V. K. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

(2010) Vinod K Batra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

(2008) Vinod K. Batra et al.   MOLECULAR CELL

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase  

(2008) P. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA