Article
Oncology
Jara Palomero, Carla Panisello, Maria Lozano-Rabella, Ricky Tirtakasuma, Judit Diaz-Gomez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernandez, Ana Vivancos, Carlos E. de Andrea, Ignacio Melero, Jordi Ponce, August Vidal, Josep Maria Piulats, Xavier Matias-Guiu, Alena Gros
Summary: Our study investigates the prevalence, phenotype, specificity and prognostic value of tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC). We found that CD8(+)TILs expressing high levels of PD-1 and CD39 were associated with tumor reactivity and improved patient survival. The co-expression of inhibitory and activation markers on PD-1(hi) CD4(+) T cells was also observed, which accumulated antitumor T cells and correlated with prolonged survival in EC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Chong Zhang, Xiang-Yu Wang, Jie-Liang Zuo, Xue-Fu Wang, Xiao-Wen Feng, Bo Zhang, Yi-Tong Li, Chen-He Yi, Peng Zhang, Xiao-Chen Ma, Zhen-Mei Chen, Yue Ma, Jia-Hao Han, Bao-Rui Tao, Rui Zhang, Tian-Qi Wang, Li Tong, Wang Gu, Si-Yu Wang, Xiao-Fei Zheng, Wen-Kang Yuan, Zi-Jie Kan, Jie Fan, Xiang-Yang Hu, Jun Li, Chao Zhang, Jin-Hong Chen
Summary: Tertiary lymphoid structures (TLSs) in colorectal cancer liver metastases (CRCLM) are found to be associated with prognosis. The study analyzed data from 603 CRCLM patients and found that higher intratumor TLSs score is correlated with better prognosis, while higher peritumor TLSs score is correlated with poorer survival. Additionally, the study also found a correlation between immune cell composition within TLSs and TLSs score.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Anthony Di Roio, Margaux Hubert, Laurie Besson, Marion Bossennec, Celine Rodriguez, Yenkel Grinberg-Bleyer, Guilhem Lalle, Lyvia Moudombi, Raphael Schneider, Cyril Degletagne, Isabelle Treilleux, Daniel J. Campbell, Severine Metzger, Thomas Duhen, Olivier Tredan, Christophe Caux, Christine Menetrier-Caux
Summary: This study investigated the expression, function, and regulation of MDR1 in CD4(+) T cells and its role in neoadjuvant chemotherapy in breast cancer. The results showed that MDR1 expression was associated with the enrichment of Th1.17 and Th17 cells and correlated positively with pathological response. This study has important clinical implications for adjusting chemotherapy regimens.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Clinical Neurology
Minesh Kapadia, M. Firoz Mian, Donglai Ma, Craig P. Hutton, Amber Azam, Klotilda Narkaj, Chuanhai Cao, Breanna Brown, Bernadeta Michalski, David Morgan, Paul Forsythe, Iva B. Zovkic, Margaret Fahnestock, Boris Sakic
Summary: Immunosuppression in 3xTg-AD mice prevented certain AD pathology features in males and maintained AD-like phenotype in females. This suggests a potential key role of autoimmunity in the pathogenesis of AD.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Immunology
Hugues Allard-Chamard, Faisal Alsufyani, Naoki Kaneko, Kelly Xing, Cory Perugino, Vinay S. Mahajan, Joseph L. Wheat, George S. Deepe, James Loyd, Shiv Pillai
Summary: This study found that fibrotic diseases such as fibrosing mediastinitis may be induced and activated by fungal antigens, indicating that T cells, specifically CD4(+)CTLs, play a significant role in inflammatory fibrosis. The research provides important insights into the pathogenesis of idiopathic fibrotic diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thomas K. Karikari, Andrea L. Benedet, Nicholas J. Ashton, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Paramita Saha-Chaudhuri, Firoza Lussier, Hlin Kvartsberg, Alexis Moscoso Rial, Tharick A. Pascoal, Ulf Andreasson, Michael Scholl, Michael W. Weiner, Pedro Rosa-Neto, John Q. Trojanowski, Leslie M. Shaw, Kaj Blennow, Henrik Zetterberg
Summary: Plasma phosphorylated-tau181 (p-tau181) is a promising blood-based biomarker specific for Alzheimer's disease (AD), showing high diagnostic accuracy and increasing levels with disease progression.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Ruben Smith, Nicholas C. Cullen, Alexa Pichet Binette, Antoine Leuzy, Kaj Blennow, Henrik Zetterberg, Gregory Klein, Edilio Borroni, Rik Ossenkoppele, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Oskar Hansson
Summary: Baseline tau-PET and a composite baseline cognitive score were the strongest independent predictors of cognitive decline in patients with amnestic MCI or mild dementia.
ALZHEIMERS & DEMENTIA
(2022)
Article
Oncology
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li
Summary: In this study, it was found that increased STING and CCL22 levels, as well as higher levels of FOXP3(+) cells and lower levels of CD8(+) cells in tumor tissues of cervical cancer, predicted poor survival. Activation of STING signaling in cooperation with T cell receptor and other signals promoted iTreg differentiation in both human and murine CD4(+) naive T cells. Additionally, tumor-derived exosomes were found to activate STING signaling in tumor-infiltrated T cells, leading to iTreg expansion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
David Escors, Ana Bocanegra, Luisa Chocarro, Ester Blanco, Sergio Pineiro-Hermida, Maider Garnica, Leticia Fernandez-Rubio, Ruth Vera, Hugo Arasanz, Grazyna Kochan
Summary: PD-L1/PD-1 blockade immunotherapy has revolutionized cancer treatment, but its mechanisms and effectiveness are still not fully understood. This article reviews the evidence supporting the role of CD4 T cells in anti-tumor immunity and their potential as predictors of response to PD-L1/PD-1 blockade immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Oncology
Karen Kai-Lin Fang, Jongbok Lee, Ismat Khatri, Yoosu Na, Li Zhang
Summary: The use of allogeneic CAR4-DNTs as adoptive cell therapy for T-cell malignancies is effective. CAR4-DNTs can effectively target T-ALL and PTCL and have superior cytotoxicity compared to empty-vector transduced DNTs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Neurosciences
Heikki Lukkarinen, Aleksi Vanninen, Ina Tesseur, Darrel Pemberton, Peter Van der Ark, Tarja Kokkola, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Kaj Blennow, Henrik Zetterberg, Ville Leinonen
Summary: There is a concentration gradient of Alzheimer's disease cerebrospinal fluid (CSF) biomarkers, including amyloid-beta 1-42 (A beta(42)), total tau (T-tau), and phosphorylated tau 181 (P-tau(181)), between intraventricular (V-CSF) and lumbar CSF (L-CSF) in iNPH patients. The study provides conversion factors between V-CSF and L-CSF, which can be used for diagnostic and prognostic purposes. Linear correlations were found between V-CSF and L-CSF concentrations, both pre- and post-operatively. The equations presented in this study offer a novel tool for clinical use when L-CSF samples are not available or when less invasive shunt reservoir samples are interpreted.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Microbiology
Jacob T. Bailey, Safiehkhatoon Moshkani, Catherine Rexhouse, Jesse L. Cimino, Michael D. Robek
Summary: Hepatitis B virus (HBV) is a leading cause of viral hepatitis with a significant impact on global mortality. Although there is currently no highly effective cure for chronic HBV infection, immunotherapy has emerged as a potential treatment option due to its association with HBV-specific immune responses. However, the lack of suitable animal models for studying HBV has posed challenges in understanding the natural immune response to the virus. This study used a mouse model of HBV replication and demonstrated the crucial role of CD4(+) T cells in the antibody-mediated clearance of HBsAg, as well as their ability to reverse HBsAg persistence.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci
Summary: This study investigated the role of CD4 and CD8 T cells in CD19 CAR-T cell responses and the development of cytokine release syndrome (CRS). CD4 CAR-T cells exhibited superior proliferation and activation potential compared to CD8 CAR-T cells. CD4 CAR-T cells were found to play a key role in the development of CRS, and CD4 CAR-T cells with embedded 4-1BB were associated with a safer profile. CD4 cells were crucial for maintaining long-term responses and the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity without compromising antitumor efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Murilo Delgobo, Margarete Heinrichs, Nils Hapke, DiyaaElDin Ashour, Marc Appel, Mugdha Srivastava, Tobias Heckel, Ioakim Spyridopoulos, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: The cardiovascular and immune systems undergo significant changes with aging, and an accumulation of CD4(+) T cells in elderly individuals may contribute to myocardial aging and heart disease progression. By studying young mice with expanded CD4(+) T cell compartments, researchers found that these cells can differentiate and impact the heart, suggesting a link between immunological senescence and age-related cardiac deterioration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)