Article
Behavioral Sciences
Anhui Fu, Fei Qiao, Hao Feng, Qing Luo
Summary: Neuroinflammation is a crucial pathophysiological process in depression. This study investigated the role of TREM-1 and its inhibition in depression using a mouse model induced by LPS. The results showed that TREM-1 inhibition by LP17 could alleviate depressive-like behaviors induced by LPS by mitigating neuroinflammation in the prefrontal cortex via the PI3K/Akt signaling pathway. These findings suggest that TREM-1 may be a promising therapeutic target for the treatment of depression.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Cell Biology
Brittani R. Price, Lance A. Johnson, Christopher M. Norris
Summary: Astrocyte reactivity is a key feature of neuroinflammation in Alzheimer's disease and other neurodegenerative conditions, with roles extending beyond classic inflammatory processes to include synapse function, brain metabolism, neurovascular coupling, and sleep/wake patterns. Understanding astrocyte signaling is leading to new drug targets and treatment approaches for dementia, potentially reshaping our understanding of AD pathophysiology.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Xiao-Yi Feng, Hai-Dong Hu, Jian Chen, Cheng Long, Li Yang, Lei Wang
Summary: Emerging literature suggests that acute neuroinflammation is beneficial for CNS homeostasis and cognitive integrity, but its neurophysiological effects on cognitive function are not well understood. A study found that acute neuroinflammation led to hyperexcitable PV interneurons in the mPFC, which may mediate neuronal recruitment and have a beneficial outcome on functional integrity of memory circuits.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Sijia Li, Chenguang Zhou, Yinghui Zhu, Zhiwen Chao, Zhiyuan Sheng, Yongxin Zhang, Yuanzheng Zhao
Summary: The study shows that Ferrostatin-1 can effectively protect astrocytes from ferroptosis induced by Angiotensin II, reduce the production of inflammatory factors, and exert protective effects by activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Gabriel Henrique Schirmbeck, Marina Seady, Fernanda Telles Froes, Jessica Taday, Carollina Da Re, Jessica Maria Souza, Carlos Alberto Goncalves, Marina Concli Leite
Summary: This study investigated the impact of low-grade repeated inflammation stimuli induced by LPS on hippocampal function and spatial memory in rats. The findings suggest that long-term repeated systemic inflammation can lead to memory impairment and disturbance in astrocyte function.
Article
Cell Biology
Ji-an Wei, Linglin Liu, Xichen Song, Bilian Lin, Jing Cui, Lanzhi Luo, Yuchu Liu, Shihua Li, Xiaojiang Li, Kwok-Fai So, Sen Yan, Li Zhang
Summary: The aggregation of TDP-43 is associated with various neurodegenerative diseases, leading to microglial activation and neuronal loss. This study establishes a mouse model with overexpression of mutant TDP-43, which results in motor-learning deficits. Microglia are observed to approach parvalbumin interneurons, disrupting cortical excitatory-inhibitory balance. Activation of the complement pathway is found to induce microglial activity. Treadmill exercise prevents motor dysfunction by blocking the complement pathway through enhanced release of clusterin. These findings provide new insights into the mechanism of TDP-43-induced cortical deficits and the role of exercise training in disease intervention.
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Yaping Guo, Mingna Sun, Li Li, Wenbin He
Summary: This study found that chrysin, a natural flavonoid compound, can alleviate neuroinflammation and depressive-like behaviors induced by chronic stress by inhibiting the activation of Fyn and NF-κB pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
David Pamies, Chiara Sartori, Domitille Schvartz, Victor Gonzalez-Ruiz, Luc Pellerin, Carolina Nunes, Denise Tavel, Vanille Maillard, Julien Boccard, Serge Rudaz, Jean-Charles Sanchez, Marie-Gabrielle Zurich
Summary: This study aimed to explore the metabolic changes occurring in activated human astrocytes. Results showed that activated astrocytes exhibited significant changes in inflammation response, cytoskeleton, and energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Wael A. A. Alanazi, Turki Alharbi, Doaa M. M. El-Nagar, Abdullah M. M. Albogami, Mohammed Alswayyed
Summary: In this study, it was found that the SGLT2 inhibitor dapagliflozin attenuated lipopolysaccharide-induced hypotension by inhibiting vasodilation and reducing cytokine levels. This protective effect was independent of glycemic control and applicable to patients with different glucose levels.
Review
Neurosciences
Daniel Reyes-Haro
Summary: Anorexia is a common eating disorder, especially among adolescent females, characterized by a fear of gaining weight due to body image distortion, leading to reduced food intake and severe weight loss. Glial cells may play a significant role in anorexia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Immunology
Jia-Hui He, Rong-Pei Liu, Yi-Man Peng, Qing Guo, Lan-Bing Zhu, Yi-Zhi Lian, Bei-Lei Hu, Hui-Hui Fan, Xiong Zhang, Jian-Hong Zhu
Summary: The study found that SSRIs have visible cytotoxicity to astrocytes and show a paradoxical effect on astrocytic inflammatory responses. The SNRI venlafaxine has the least toxicity to astrocytes and inhibits the production of certain inflammatory factors. The antidepressants alter astrocytic inflammation through inhibition of specific signaling pathways.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Neurosciences
Jill M. M. Lawrence, Kayla Schardien, Brian Wigdahl, Michael R. R. Nonnemacher
Summary: In the contexts of aging, injury, or neuroinflammation, activated microglia induce neurotoxic astrocytes that downregulate supportive functions and secrete neurotoxic factors, complement components, and chemokines, which may facilitate immune cell recruitment. The proportion of pro-inflammatory reactive astrocytes increases with age and is particularly abundant in neurodegenerative disorders. As the identification of astrocyte phenotypes progress, their molecular and cellular effects are characterized in a growing array of neuropathologies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Xiaoli Liao, Miao Chen, Yamin Li
Summary: The present study aimed to review evidence from postmortem brain and PET studies on the role of glia induced neuroinflammation in the pathogenesis of ASD. The findings from postmortem studies showed increased microglial number and density, as well as increased GFAP protein and mRNA expression in ASD subjects. However, the outcomes of PET studies were inconsistent, with one reporting increased TSPO expression and two reporting decreased TSPO expression in ASD subjects.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Immunology
Qingchen Wang, Zhiping Yang, Xintong Wu, Xiao Zhang, Feng Geng, Qiaoyun Wang, Zikai Geng, Chen Yu, Zhipeng Li
Summary: The study demonstrates that chrysin inhibits the activation of Fyn kinase, alleviating neuroinflammation-induced neuron damage and behavior deficits. It also reduces the expression of inflammatory molecules by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rehabilitation
Yong-Il Shin, Soo-Yeon Kim, Hae In Lee, Deog Young Kim, Jongmin Lee, Min Kyun Sohn, Sam-Gyu Lee, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han, Junhee Han, Myung Hoon Moon, Won Hyuk Chang, Youngtaek Kim, Yun-Hee Kim
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2018)
Article
Rehabilitation
Sungju Jee, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Ii Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han, Yun-Hee Kim
JOURNAL OF REHABILITATION MEDICINE
(2018)
Article
Rehabilitation
Yejin Lee, Hyun-Haeng Lee, Kyeong Eun Uhm, Ho Joong Jung, Yoon-Sook Kim, Jinyoung Shin, Jaekyung Choi, Seol-Heui Han, Jongmin Lee
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2019)
Article
Biochemistry & Molecular Biology
Dong-Hee Choi, In-Ae Choi, Cheol Soon Lee, Ji Hee Yun, Jongmin Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Medicine, General & Internal
Junhee Han, Hae In Lee, Yong-Il Shin, Ju Hyun Son, Soo-Yeon Kim, Deog Young Kim, Min Kyun Sohn, Jongmin Lee, Sam-Gyu Lee, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han, Won Hyuk Chang, Yun-Hee Kim
Article
Biochemistry & Molecular Biology
In-Ae Choi, Ji Hee Yun, Ji-Hye Kim, Hahn Young Kim, Dong-Hee Choi, Jongmin Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Dong Bin Back, Bo-Ryoung Choi, Jung-Soo Han, Kyoung Ja Kwon, Dong-Hee Choi, Chan Young Shin, Jongmin Lee, Hahn Young Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Health Care Sciences & Services
Minyoung Shin, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Seyoung Shin, Soo Mi Choi, Seon Kui Lee, Yun-Hee Kim
Summary: This study investigated the impact of post-stroke depression (PSD) on cognitive aging in elderly stroke patients. The results showed that early PSD increased the risk of cognitive decline in older stroke patients, mainly in males. Older male patients with negative thinking were at increased risk of cognitive decline, and older women may also be at risk for cognitive decline.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Dong-Hee Choi, In-Ae Choi, Jongmin Lee
Summary: This review discusses the role of DNA methylation in neuroprotection and neuronal recovery after stroke. It summarizes the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. Investigating the modulation of DNA methyltransferase, demethylase, and MBD protein expression can aid in the formulation of therapeutic strategies for stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Yea Jin Jo, Dae Hyun Kim, Min Kyun Sohn, Jongmin Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun-Hee Kim, Deog Young Kim
Summary: Stroke in young adults has increased and is more likely to be hemorrhagic compared to older adults. Lifestyle-related risk factors such as obesity, smoking, and heavy alcohol consumption are more common in the younger group, while other cardiovascular risk factors are more frequent in the older group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Primary Health Care
Kyoung Jin Kim, Jinyoung Shin, Jaekyung Choi, Jae-Min Park, Hyoung Keun Park, Jongmin Lee, Seol-Heui Han
KOREAN JOURNAL OF FAMILY MEDICINE
(2019)
Correction
Clinical Neurology
Min-Su Kim, Min Cheol Joo, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Soo-Yeon Kim, Gyung-Jae Oh, Yang-Soo Lee, Eun Young Han, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun-Hee Kim
JOURNAL OF CLINICAL NEUROLOGY
(2019)
Article
Geriatrics & Gerontology
Kyeong Eun Uhm, Minsun Kim, Yong Min Lee, Bo-Ram Kim, Yoon-Sook Kim, Jaekyung Choi, Seol-Heui Han, Hee Joung Kim, Kwang Ha Yoo, Jongmin Lee
EUROPEAN GERIATRIC MEDICINE
(2019)
Article
Clinical Neurology
Min-Su Kim, Min Cheol Joo, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Soo-Yeon Kim, Gyung-Jae Oh, Yang-Soo Lee, Eun Young Han, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun-Hee Kim
JOURNAL OF CLINICAL NEUROLOGY
(2019)
Article
Rehabilitation
Bo-Ram Kim, Yejin Lee, Soo Jin Kim, Hyuntae Kim, Jong Won Lee, Seunghwan Lee, Jongmin Lee
ANNALS OF REHABILITATION MEDICINE-ARM
(2018)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)