Article
Biochemistry & Molecular Biology
Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study found that exosomes derived from dermal papilla cells regulate hair follicle stem cell proliferation by stimulating LEF1, providing new insights into the regulatory mechanisms of hair follicle growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jae Young Shin, Jaeyoon Kim, Yun-Ho Choi, Nae-Gyu Kang, Sanghwa Lee
Summary: The study revealed that D-panthenol can enhance the viability of hair follicle cells, suppress apoptotic and senescence markers, and promote the elongation of the anagen phase in hair follicles.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Engineering, Chemical
Hanluo Li, Jule Kristin Michler, Alexander Bartella, Anna Katharina Sander, Sebastian Gaus, Sebastian Hahnel, Ruediger Zimmerer, Jan-Christoph Simon, Vuk Savkovic, Bernd Lethaus
Summary: This study successfully translated the technology of human outer root sheath (ORS) to horses, resulting in the culture of equine melanocytes from hair follicles. The procedure was adjusted to fit equine physiology, providing an experimental base for further understanding of hair follicle biology in horses.
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Dermatology
Fang Liu, Si Liu, Xiaohua Luo, Zirui Fan, Shaobin Huang, Fangqi Deng, Huanliang Liu, Ge Shi
Summary: The study demonstrates that exosomes derived from DSCCs have an anti-ageing effect on DPCs, promoting their proliferation, viability, and migration while inhibiting apoptosis. The exosomes also enhance hair follicle induction ability and activate relevant signaling pathways, potentially serving as a new strategy for preventing senile alopecia.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fan Li, Hongli Liu, Xiaojing Wu, Zhicheng Song, Haojia Tang, Maohua Gong, Lei Liu, Fuchang Li
Summary: Dermal papilla cells (DPCs) play important roles in hair growth regulation, but strategies to regrow hair are lacking. This study found that copper depletion severely impaired the key marker of hair growth in DPCs by increasing excessive ROS production, leading to decreased ATP production, mitochondrial membrane potential depolarization, and increased total cellular ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Mayumi Ikeda, Shigeharu Yabe, Masahiro Kiso, Naoko Ishiguro, Yuichiro Tsunemi, Hitoshi Okochi
Summary: This study evaluated the function of TERT and BMI1 in human DPCs. The results showed that overexpression of both TERT and BMI1 extends the lifespan of human DPCs and improves their hair inducing ability on mouse hair follicles.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Cell Biology
Carla M. Abreu, Rui L. Reis, Alexandra P. Marques
Summary: The study showed that under 5% oxygen levels, human dermal papilla cells and melanocytes exhibited improved physiological state and phenotype, with interactions between them enhancing hair growth and pigmentation. The findings provide important insights for research on hair regeneration.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Bohao Zhao, Jiali Li, Ming Liu, Shuaishuai Hu, Naisu Yang, Shuang Liang, Xiyu Zhang, Yingying Dai, Zhiyuan Bao, Yang Chen, Xinsheng Wu
Summary: The study reveals the important role of lncRNA2919 in the cyclic regeneration of hair follicles, as it regulates the expression of related genes and affects cell proliferation and apoptosis processes, thus influencing the growth and development of hair follicles.
Article
Cell Biology
Masahiro Fukuyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano, Manabu Ohyama
Summary: This study attempted to reproduce the anatomical relationship between the epithelial main body and the dermal papilla within hair follicles in vitro and evaluated how follicle characteristics were reproduced in constructs. Using hiPSC-derived cell composites, the study showed promising potential for regenerating hair follicle equivalents with in vitro hair inductive capacity, reducing the reliance on human tissue-derived trichogenic cell subsets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Dermatology
Pieter A. Martino, Nicholas Heitman, Michael Rendl
Summary: Hair follicles cyclically regenerate in adult mammals due to stem cell activity. The dermal papilla plays a crucial role in regulating stem cell activation and progenitor proliferation and differentiation during follicle growth.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanluo Li, Federica Francesca Masieri, Marie Schneider, Alexander Bartella, Sebastian Gaus, Sebastian Hahnel, Ruediger Zimmerer, Ulrich Sack, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Jan-Christoph Simon, Bernd Lethaus, Vuk Savkovic
Summary: The mid part of the hair follicle outer root sheath (ORS) contains a rich population of stem cells with the potential to give rise to multiple stem cell types in vitro. Comparative analysis shows that the mid-ORS part exhibits higher expression levels of key markers at both the protein and gene levels when compared to the distal ORS part.
Article
Dermatology
Ningxia Zhu, Junping Yan, Weifan Gu, Qilin Yang, En Lin, Siyue Lu, Bozhi Cai, Bin Xia, Xin Liu, Changmin Lin
Summary: This study found that biglycan plays a critical role in regulating hair follicle cycle and regeneration by activating the Wnt/beta-catenin signaling pathway. Local injection of biglycan delayed the progression of the catagen phase and induced hair follicle regeneration.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Young Kwan Sung, Jaetae Lee, Byeong-Cheol Ahn
Summary: The study revealed that hFB-EVs play a role in promoting hair growth by enriching Wnt3a, Axin2, and Lef1 genes in DP and ORS cells, leading to increased migration, proliferation, and differentiation, as well as elongation of the hair shaft in human HFs.
Article
Medicine, General & Internal
Yuhong Chen, Lijuan Zhou, Yuxin Ding, Xiaoshuang Yang, Jing Jing, Xianjie Wu, Jufang Zhang, Zhongfa Lu
Summary: Kartogenin promotes the proliferation and migration of hair follicles and delays the transition phase of the hair growth cycle in mice. It achieves these effects by modulating the TGF-beta 2/Smad signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)