Article
Plant Sciences
Jie Wang, Yun-Shan Wang, Ya-Ping Huang, Cui-Hua Jiang, Meng Gao, Xian Zheng, Zhi-Qi Yin, Jian Zhang
Summary: The study identified that Gypenoside LVI enhances LDL uptake into HepG2 cells by inhibiting PCSK9 expression, indicating its potential as a useful supplement for the treatment of hypercholesterolemia. It is the first report that the monomeric compound of G. pentaphyllum planted in Hunan province has the effect of increasing LDL-C uptake in hepatocytes by inhibiting PCSK9 expression.
Article
Neurosciences
Jing Huang, Jingmei Xiao, Zhuang Peng, Ping Shao, Mengxi Sun, Yujun Long, Xiaoyi Wang, Manjun Shen, Dongyu Kang, Ye Yang, Xingjie Peng, Weiyan Wang, Peng Xie, Tiannan Shao, Jingping Zhao, Renrong Wu
Summary: This study investigates the mechanism of dyslipidemia induced by olanzapine in schizophrenic patients. Results show that olanzapine directly affects lipid metabolism independent of weight gain. Olanzapine administration increases plasma PCSK9, which is associated with the increment in LDL-C. The study suggests that SREBP-1c plays an important role in regulating lipoprotein metabolism after olanzapine treatment.
PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hua Zheng, Tao Zhao, Yi-Chuang Xu, Dian-Guang Zhang, Yu-Feng Song, Xiao-Ying Tan
Summary: Choline can prevent high-fat diet-induced cholesterol accumulation and increase bile acid synthesis through the SREBP-2/HNF-4 alpha/CYP7A1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Multidisciplinary Sciences
Wenqiang Zhu, Chen Ding, Piaopiao Huang, Juanli Ran, Pingan Lian, Yaxin Tang, Wen Dai, Xiansheng Huang
Summary: This study found that olanzapine, a drug commonly used to treat schizophrenia, can cause non-alcoholic fatty liver disease (NAFLD) by upregulating PCSK9 through LXR alpha. Metformin was shown to ameliorate the pathological alterations associated with olanzapine-induced NAFLD.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Silvia Da Ros, Giulia Nicoletto, Riccardo Rigo, Silvia Ceschi, Eleonora Zorzan, Mauro Dacasto, Mery Giantin, Claudia Sissi
Summary: The regulation of conformational arrangements of gene promoters is a crucial physiological mechanism for fine control of gene expression. By studying the G-quadruplex forming sites in the KIT promoter, it was found that different G4 sites impact SP1 binding and protein expression levels, with kit2 and kit* serving as an on-off system for KIT expression. Using two G4 binders could potentially target kit2-kit* as a reliable pharmacological intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xin Li, Xueling Hu, Tengfei Pan, Lei Dong, Lili Ding, Zhenzhong Wang, Rui Song, Xiuzhu Wang, Ning Wang, Yan Zhang, Jinhui Wang, Baofeng Yang
Summary: KLX has efficient lipid-lowering effects by activating the AMPK/SREBP-2/PCSK9/LDLR signaling pathway, providing a potential new lipid-lowering drug for hyperlipidemia, fatty liver, and cardiovascular disease prevention and treatment in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Yudong Wang, Jianing Zhang, Zheng Xu, Guifang Zhang, Huijuan Lv, Xinben Wang, Guijing Xu, Xuefeng Li, Zhigang Yang, Haoliang Wang, Yongfu Wang, Hongfang Li, Yanbin Shi
Summary: Rhei Radix et Rhizoma has been widely used in Traditional Chinese Medicine for its various therapeutic effects. Modern pharmacological research has shown its potential in lowering blood lipids, but the specific active components and mechanisms are still unclear.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Virology
Jeffery B. Ostler, Prasanth Thunuguntla, Bailey Y. Hendrickson, Clinton Jones
Summary: Following acute infection, herpes simplex virus 1 (HSV-1) establishes lifelong latency in neurons, with certain external stimuli triggering reactivation. Stress-induced transcription factors have been shown to cooperatively activate the expression of the viral transcriptional regulator ICP4, required for productive infection. This suggests that stressful stimuli can lead to productive infection by activating ICP4 expression through cooperation between glucocorticoid receptor (GR) and specific stress-induced transcription factors.
JOURNAL OF VIROLOGY
(2021)
Article
Biology
Alicia Tapias, David Lazaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Summary: The study reveals the importance of TRRAP for neuroprotection and the network connecting TRRAP, HAT, and SP1 in regulating microtubule dynamics.
Review
Biochemistry & Molecular Biology
Fang Liu, Xiao Zhu, Xiaping Jiang, Shan Li, Yuncheng Lv
Summary: The review highlights the roles and underlying mechanisms of hepatic nuclear factor-1 (HNF-1) in lipid metabolism and the development of lipid metabolism disorders. HNF-1 regulates the expression of lipid-related genes to influence lipid metabolism balance and suppress the development of lipid metabolism disorders.
Article
Pharmacology & Pharmacy
Ningning Ma, Lei Fan, Yunxia Dong, Xiaoding Xu, Chuwei Yu, Jing Chen, Jin Ren
Summary: The study identified miR-552-3p as a new PCSK9 inhibitor with a dual inhibition mechanism, showing that it can inhibit PCSK9 translation and suppress transcription by interacting with its promoter. MiR-552-3p also affects LDL-C levels in mice on a high fat diet by increasing LDLR protein levels and promoting LDL-C uptake in HepG2 cells.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Maximillian A. Rogers, Joshua D. Hutcheson, Takehito Okui, Claudia Goettsch, Sasha A. Singh, Arda Halu, Florian Schlotter, Hideyuki Higashi, Lixiang Wang, Mary C. Whelan, Andrew K. Mlynarchik, Alan Daugherty, Masatoshi Nomura, Masanori Aikawa, Elena Aikawa
Summary: The study demonstrates that inhibition of the mitochondrial fission protein DRP1 can reduce remodeling of specific ER microdomains, promoting mitochondrial fission, autophagy, and enhancing mitochondrial calcium buffering and PCSK9 degradation. The findings suggest a novel role of DRP1 in regulating hepatic proteostasis and mdivi-1 as a potential small molecule PCSK9 inhibitor.
CARDIOVASCULAR RESEARCH
(2021)
Article
Virology
Rachid Essalmani, Ursula Andreo, Alexandra Evagelidis, Mailys Le Devehat, Oscar Henrique Pereira Ramos, Carole Fruchart Gaillard, Delia Susan-Resiga, Eric A. Cohen, Nabil G. Seidah
Summary: This study investigates the involvement of cholesterol-regulating enzymes SKI-1 and PCSK9 in the entry of SARS-CoV-2. SKI-1 enhances cell-to-cell fusion by activating SREBP-2, while PCSK9 reduces cell-to-cell fusion by promoting the degradation of ACE2. Both SKI-1 and PCSK9 modulate SARS-CoV-2 entry through independent mechanisms.
Article
Biotechnology & Applied Microbiology
Nivas Shyamala, Kishore Kumar Gundapaneni, Rajesh Kumar Galimudi, Mohini Aiyengar Tupurani, Chiranjeevi Padala, Kaushik Puranam, Keerthi Kupsal, Ramanjaneyulu Kummari, Srilatha Reddy Gantala, Krishna Reddy Nallamala, Sanjib K. Sahu, Surekha Rani Hanumanth
Summary: This study suggests that specific genetic variations of the PCSK9 gene are associated with the risk of CAD, indicating potential therapeutic effects of rs11591147 genotype and promoter DNA methylation status on CAD management.
JOURNAL OF GENE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tung-Yu Tiong, Pei-Wei Weng, Chun-Hua Wang, Syahru Agung Setiawan, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, Chi-Tai Yeh, Chia-Hung Hsu, Kuang-Tai Kuo
Summary: This study investigated the role of SREBP-1 in NSCLC biology, progression, and therapeutic response and found that the targeting of SREBP-1/hsa-miR-497 signaling axis could be a potentially effective anticancer therapeutic strategy for NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Brett Hoffman, Qing Shi, Qiang Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Virology
Qing Shi, Brett Hoffman, Qiang Liu
Article
Virology
Qi Wu, Zhubing Li, Qiang Liu
Article
Virology
Hong-Su Park, GuanQun Liu, Sathya N. Thulasi Raman, Shelby L. Landreth, Qiang Liu, Yan Zhou
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Hong-Su Park, Guanqun Liu, Qiang Liu, Yan Zhou
Article
Multidisciplinary Sciences
GuanQun Liu, Yao Lu, Sathya N. Thulasi Raman, Fang Xu, Qi Wu, Zhubing Li, Robert Brownlie, Qiang Liu, Yan Zhou
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Qi Wu, Zhubing Li, Paul Mellor, Yan Zhou, Deborah H. Anderson, Qiang Liu
SCIENTIFIC REPORTS
(2017)
Article
Virology
GuanQun Liu, Yao Lu, Qiang Liu, Yan Zhou
JOURNAL OF VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mangyung Kandangwa, Qiang Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Rajan George, Allan Ma, Bruce Motyka, Yuenian Eric Shi, Qiang Liu, Philip Griebel
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Virology
Fangzheng Wang, Guanqun Liu, Yao Lu, Magda Hlasny, Qiang Liu, Yan Zhou
Article
Biochemistry & Molecular Biology
Mangyung Kandangwa, Qiang Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Virology
Hai Trong Nguyen, Darryl Falzarano, Volker Gerdts, Qiang Liu
Summary: The study established a noninfectious and BSL2-compatible SARS-CoV-2 replicon system with a sensitive and easily quantifiable reporter, providing a valuable tool for testing antiviral drugs and studying the biology of SARS-CoV-2. This system can be safely used in BSL2 laboratories, contributing to the global efforts in combating the COVID-19 pandemic.
JOURNAL OF VIROLOGY
(2021)
Review
Virology
Priya Yelemali, Lin Hao, Qiang Liu
Summary: This review summarizes the current understanding of how the nucleocapsid proteins of PEDV and SARS-CoV-2 modulate type I interferon responses, emphasizing the importance of this knowledge for developing strategies to combat coronavirus infections.
ARCHIVES OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)