Journal
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
Volume 55, Issue -, Pages 49-58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpobgyn.2018.06.010
Keywords
Menopause; Chemotherapy; Breast neoplasm; Fertility; Cyclophosphamide
Categories
Ask authors/readers for more resources
Globally, breast cancer is the most common female reproductive cancer. Although alkylating chemotherapy is not part of initial curative-intent treatment in women with other reproductive cancers, it is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from reduced bone mineral density. Although cryopreservation of embryos and oocytes is often effective for fertility preservation, this does not prevent COF and its associated complications. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in reducing the risk of COF. Concurrent GnRHa use should be considered for all premenopausal women planned to commence alkylating chemotherapy for curable cancer, regardless of their childbearing status, to further improve survivorship for women diagnosed with cancer. (C) 2018 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available