Journal
FEBS LETTERS
Volume 589, Issue 5, Pages 608-614Publisher
WILEY
DOI: 10.1016/j.febslet.2015.01.025
Keywords
Lipolysis; Adipocyte; Aquaporin-7; Comparative gene identification 58
Funding
- Japan Society for the Promotion of Science [21657053]
- Japan Science and Technology Agency (Strategic International Research Cooperative Program)
- Nateglinide Memorial Toyoshima Research and Education Fund
- Keio Gakuji Academic Development Funds
- Keio University
- Grants-in-Aid for Scientific Research [21657053, 15J02898] Funding Source: KAKEN
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Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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