The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis

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A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

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A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma

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TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

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Direct, Noncatalytic Mechanism of IKK Inhibition by A20

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

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Linear ubiquitination prevents inflammation and regulates immune signalling

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

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Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

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Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

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TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

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Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

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Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

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c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

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cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

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Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

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