The SAFE pathway for cardioprotection: is this a promising target?

Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial

(2017) Qingping Wu et al.   EUROPEAN HEART JOURNAL

Cardioprotective Effects of Transfusion of Late-Phase Preconditioned Plasma May Be Induced by Activating the Reperfusion Injury Salvage Kinase Pathway but Not the Survivor Activating Factor Enhancement Pathway in Rats

(2017) Yang Zhao et al.   Oxidative Medicine and Cellular Longevity

Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3

(2017) Hengxun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Potential humoral mediators of remote ischemic preconditioning in patients undergoing surgical coronary revascularization

(2017) Nilgün Gedik et al.   Scientific Reports

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia–reperfusion injury: role of RISK and SAFE pathways interaction

(2016) Liming Yu et al.   APOPTOSIS

Understanding STAT3 signaling in cardiac ischemia

(2016) K. E. O’Sullivan et al.   BASIC RESEARCH IN CARDIOLOGY

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

(2016) Derek J. Hausenloy et al.   BASIC RESEARCH IN CARDIOLOGY

Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury

(2015) Karol Szczepanek et al.   BASIC RESEARCH IN CARDIOLOGY

Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement PathwaysNovelty and Significance

(2015) Andreas Skyschally et al.   CIRCULATION RESEARCH

Cardio-protective Signalling by Glyceryl Trinitrate and Cariporide in a Model of Donor Heart Preservation

(2015) Jair C. Kwan et al.   Heart Lung and Circulation

Role of toll-like receptor 4 in melatonin-induced cardioprotection

(2015) Frederic Nduhirabandi et al.   JOURNAL OF PINEAL RESEARCH

Improving Reconstituted HDL Composition for Efficient Post-Ischemic Reduction of Ischemia Reperfusion Injury

(2015) Marie-Claude Brulhart-Meynet et al.   PLoS One

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction

(2014) Julia Müller et al.   BASIC RESEARCH IN CARDIOLOGY

RISK and SAFE Signaling Pathway Involvement in Apolipoprotein A-I-Induced Cardioprotection

(2014) Hussein Kalakech et al.   PLoS One

HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity

(2013) Miguel A. Frias et al.   ATHEROSCLEROSIS

Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

(2013) C. Penna et al.   BASIC RESEARCH IN CARDIOLOGY

The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

(2013) Kerstin Boengler et al.   CURRENT PHARMACEUTICAL DESIGN

GH-Releasing Hormone Induces Cardioprotection in Isolated Male Rat Heart via Activation of RISK and SAFE Pathways

(2013) Claudia Penna et al.   ENDOCRINOLOGY

Enhanced preservation of the rat heart after prolonged hypothermic ischemia with erythropoietin-supplemented Celsior solution

(2013) Alasdair J. Watson et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting

(2013) Eva Kottenberg et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

(2013) Daniel J. Gough et al.   PLoS One

Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress

(2012) Joel S. Karliner   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Interplay Between SAFE and RISK Pathways in Sphingosine-1-Phosphate–Induced Cardioprotection

(2012) Sarin J. Somers et al.   CARDIOVASCULAR DRUGS AND THERAPY

Mitochondrial STAT3 Activation and Cardioprotection by Ischemic Postconditioning in Pigs With Regional Myocardial Ischemia/Reperfusion

(2011) Gerd Heusch et al.   CIRCULATION RESEARCH

STAT5 Activation and Cardioprotection by Remote Ischemic Preconditioning in Humans

(2011) Gerd Heusch et al.   CIRCULATION RESEARCH

Tuesday, 30 August 2011

(2011)   EUROPEAN HEART JOURNAL

When are pro-inflammatory cytokines SAFE in heart failure?

(2011) S. Lecour et al.   EUROPEAN HEART JOURNAL

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

(2011) Karol Szczepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection

(2011) Kim T. Lamont et al.   JOURNAL OF PINEAL RESEARCH

Reperfusion Injury Salvage Kinase and Survivor Activating Factor Enhancement Prosurvival Signaling Pathways in Ischemic Postconditioning: Two Sides of the Same Coin

(2010) Derek J. Hausenloy et al.   ANTIOXIDANTS & REDOX SIGNALING

TNFα protects cardiac mitochondria independently of its cell surface receptors

(2010) Lydia Lacerda et al.   BASIC RESEARCH IN CARDIOLOGY

Ethanolamine is a novel STAT-3 dependent cardioprotective agent

(2010) Roisin F. Kelly et al.   BASIC RESEARCH IN CARDIOLOGY

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

(2010) Denise Hilfiker-Kleiner et al.   CIRCULATION

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway

(2009) Lydia Lacerda et al.   CARDIOVASCULAR RESEARCH

Tumor Necrosis Factor-α and Its Receptors 1 and 2

(2009) Rainer Schulz et al.   CIRCULATION

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

(2009) Sandrine Lecour   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning

(2008) N. Suleman et al.   CARDIOVASCULAR RESEARCH

The myocardial JAK/STAT pathway: From protection to failure

(2008) K BOENGLER et al.   PHARMACOLOGY & THERAPEUTICS

Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice

(2007) Kerstin Boengler et al.   CIRCULATION RESEARCH