Review
Cell Biology
Jing Li, Wei Wang
Summary: Peroxisomes play essential roles in cellular metabolism, and their dynamic homeostasis is maintained through biogenesis and turnover. Dysregulation of peroxisomes can lead to disease development, highlighting the importance of understanding pexophagy mechanisms.
Article
Cell Biology
Michael S. Dahabieh, Fan Huang, Christophe Goncalves, Raul Ernesto Flores Gonzalez, Sathyen Prabhu, Alicia Bolt, Erminia Di Pietro, Elie Khoury, John Heath, Zi Yi Xu, Joelle Remy-Sarrazin, Koren K. Mann, Alexandre Orthwein, Francois-Michel Boisvert, Nancy Braverman, Wilson H. Miller, Sonia V. del Rincon
Summary: Promoting autophagy-mediated degradation of specific proteins and organelles can induce apoptosis in cancer cells or sensitize them to therapy. Targeting peroxisome homeostasis through increased pexophagy can enhance sensitivity to treatment, as shown in lymphoma, lung cancer, and melanoma models.
Article
Microbiology
Celine Yen Ling Choo, Pei-Ching Wu, Jonar I. Yago, Kuang-Ren Chung
Summary: In this study, the researchers discovered a microbody called peroxisomes that are involved in fatty acid and hydrogen peroxide metabolism in eukaryotes. They found that the AaPex3 gene is responsible for peroxisome biogenesis and resistance to peroxides and superoxide-generating compounds. AaPex3 also affects gene expression related to ROS resistance and is involved in maintaining cell wall integrity and various important functions in the phytopathogenic fungus.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaofan Wei, Yunash Maharjan, Debra Dorotea, Raghbendra-Kumar Dutta, Donghyun Kim, Hyunsoo Kim, Yizhu Mu, Channy Park, Raekil Park
Summary: PEX16 regulates peroxisome abundance and function through pexophagic degradation, which is indispensable for maintaining peroxisome homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shino Goto-Yamada, Kazusato Oikawa, Yasuko Hayashi, Shoji Mano, Kenji Yamada, Mikio Nishimura
Summary: Light is vital for plant growth, but excessive light can generate reactive oxygen species (ROS) that harm cells. Mutants lacking ATG genes display light intensity-dependent leaf damage and ROS accumulation. Autophagy is a crucial system for plants to defend against ROS-induced harm by eliminating oxidized peroxisomes. Damaged peroxisomes are recognized by the PtdIns3P marker and selectively engulfed by ATG18a-GFP-labeled phagophores. Under high-intensity light, large peroxisome aggregates are induced and captured by vacuolar membranes. This research enhances our understanding of plant responses to light irradiation.
Review
Medicine, Research & Experimental
Wen Li, Pengcheng He, Yuge Huang, Yi-Fang Li, Jiahong Lu, Min Li, Hiroshi Kurihara, Zhuo Luo, Tian Meng, Mashun Onishi, Changle Ma, Lei Jiang, Yongquan Hu, Qing Gong, Dongxing Zhu, Yiming Xu, Rong Liu, Lei Liu, Cong Yi, Yushan Zhu, Ningfang Ma, Koji Okamoto, Zhiping Xie, Jinbao Liu, Rong-Rong He, Du Feng
Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.
Editorial Material
Cell Biology
Theresah Nana Ama Mensah, Ankit Shroff, Taras Y. Nazarko
Summary: Selective autophagy pathways rely on selective autophagy receptors (SARs) to recognize and bridge the substrate to be degraded and the autophagic membrane. Ubiquitin is the common ligand for SARs in mammals, but yeast has only one SAR called Cue5. However, recent studies suggest that ubiquitin-dependent autophagic pathways in yeast may involve alternative ubiquitin-binding SARs. The identification of potential ubiquitin-binding proteins in yeast could lead to the discovery of novel SARs.
Article
Biochemistry & Molecular Biology
Hongli Li, Celien Lismont, Claudio F. Costa, Mohamed A. F. Hussein, Myriam Baes, Marc Fransen
Summary: This study reveals that peroxisomes, which are specialized organelles, play a role in mediating and modulating H2O2-driven processes including autophagy. The study shows that the levels of H2O2 emitted by peroxisomes can oxidatively modify autophagy receptors and core autophagy proteins, and excessive H2O2 impairs autophagic flux. The findings also suggest that peroxisomes with enhanced H2O2 release can escape selective autophagy and downregulate autophagic activity, leading to the accumulation of damaged cellular debris.
Review
Physiology
Ruth E. Carmichael, Michael Schrader
Summary: Organelle membranes are highly dynamic and exhibit plasticity, impacting the biogenesis and function of organelles. Understanding the dynamics of peroxisomal membranes is crucial for healthy cell function. Multidisciplinary research is needed to unravel the roles and regulation of peroxisome membrane dynamics.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ai My Luong, Jerome Koestel, Kaushal Kumar Bhati, Henri Batoko
Summary: Plant selective autophagy is a regulated process that degrades unnecessary or harmful components in eukaryotic cells, contributing to plant cell physiology and homeostasis. The specific cargo receptors and mechanisms involved in this pathway are not structurally conserved, highlighting the need for further research to understand evolutionary convergence and fill knowledge gaps.
Review
Biochemistry & Molecular Biology
Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Chengfu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King-Ho Cheung, Jiahong Lu, Jieqiong Tan, Min Li
Summary: Selective autophagy plays an important role in the pathogenesis of Alzheimer's disease, and regulating selective autophagy can be an effective strategy for controlling this pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Houqing Yu, Roarke A. Kamber, Vladimir Denic
Summary: Autophagy receptor proteins facilitate the destruction of organelles in response to cellular stress. However, the mechanism by which membrane-resident autophagy receptors induce selective autophagy in response to organelle-restricted signals is poorly understood. This study reveals that the ATPase activity of the Pex1/6 complex represses the activation of the pexophagy receptor Atg36 by the casein kinase Hrr25 in yeast cells. In addition, the study identifies a mechanism in which the exportomer complex represses the phosphorylation of Atg36 on Pex3 without the assistance of additional membrane factors. This mechanism prevents the induction of selective autophagy and provides insights into the regulation of organelle homeostasis.
Article
Pharmacology & Pharmacy
Yoshie Tsujiya, Ai Hasegawa, Motohiro Yamamori, Noboru Okamura
Summary: This study demonstrates that TGZ inhibits cell proliferation in lung adenocarcinoma cells through autophagy-induced cytotoxicity, independent of PPAR gamma.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Wanwan Zhang, Juehua Weng, Lan Yao, Peng Jia, Meisheng Yi, Kuntong Jia
Summary: In this study, the researchers explored how nervous necrosis virus (NNV) utilizes autophagy to promote its replication. They found that the sea perch Nectin4 (LjNectin4), as a receptor of NNV, facilitates NNV entry by directly binding to NNV capsid protein. Furthermore, LjNectin4 inhibits key elements of the RLR signaling pathway to suppress interferon (IFN) response and promote NNV replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Femke C. C. Klouwer, Kim D. Falkenberg, Rob Ofman, Janet Koster, Demi van Gent, Sacha Ferdinandusse, Ronald J. A. Wanders, Hans R. Waterham
Summary: This study investigated the potential use of autophagy inhibitors as a treatment option for PBD-ZSD patients carrying the PEX1-G843D mutation. However, the results showed that autophagy inhibitors did not improve peroxisomal functions, and in fact worsened metabolic functions and protein import in cells with the mutation. The study suggests that L-arginine remains a promising therapeutic compound for PBD-ZSD patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ewa D. Raczynska, Mariusz Sapula, Katarzyna Zientara-Rytter, Katarzyna Kolczynska, Tomasz M. Stepniewski, Malgorzata Hallmann
STRUCTURAL CHEMISTRY
(2016)
Editorial Material
Cell Biology
Katarzyna Zientara-Rytter, Suresh Subramani
Review
Biochemistry & Molecular Biology
Zientara-Rytter Katarzyna, Subramani Suresh
BIOCHEMICAL SOCIETY TRANSACTIONS
(2016)
Review
Biochemistry & Molecular Biology
Katarzyna Zientara-Rytter, Agnieszka Sirko
Editorial Material
Cell Biology
Katarzyna Zientara-Rytter, Suresh Subramani
Article
Plant Sciences
Grzegorz Moniuszko, Marek Skoneczny, Katarzyna Zientara-Rytter, Anna Wawrzynska, Dawid Glow, Simona M. Cristescu, Frans J. M. Harren, Agnieszka Sirko
JOURNAL OF EXPERIMENTAL BOTANY
(2013)
Article
Chemistry, Physical
Ewa D. Raczynska, Mariusz Makowski, Katarzyna Zientara-Rytter, Katarzyna Kolczynska, Tomasz M. Stepniewski, Malgorzata Hallmann
JOURNAL OF PHYSICAL CHEMISTRY A
(2013)
Article
Plant Sciences
Katarzyna Zientara-Rytter, Agnieszka Sirko
FRONTIERS IN PLANT SCIENCE
(2014)
Review
Cell Biology
Katarzyna Zientara-Rytter, Suresh Subramani
Review
Biochemistry & Molecular Biology
Katarzyna Zientara-Rytter, Suresh Subramani
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Cell Biology
Anil Chekuri, Katarzyna Zientara-Rytter, Angel Soto-Hermida, Shyamanga Borooah, Marina Voronchikhina, Pooja Biswas, Virender Kumar, David Goodsell, Caroline Hayward, Peter Shaw, Chloe Stanton, Donita Garland, Suresh Subramani, Radha Ayyagari
Meeting Abstract
Ophthalmology
Anil Kumar Chekuri, Katarzyna Zientara-Rytter, Shyamanga Borooah, Marina Voronchikhina, Angel Soto-Hermida, Chloe Stanton, Hiroko Matsui, Matteo D'Antonio, Peter Shaw, David S. Goodsell, Kelly Frazer, Caroline Hayward, Suresh Subramani, Radha Ayyagari
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Biology
Grzegorz Moniuszko, Katarzyna Zientara-Rytter
PERIODICUM BIOLOGORUM
(2015)
Article
Biochemistry & Molecular Biology
Katarzyna Zientara-Rytter, Agnieszka Sirko
PLANT SIGNALING & BEHAVIOR
(2014)