Structural disorder and its role in proteasomal degradation

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

(2015) Danny D. Sahtoe et al.   MOLECULAR CELL

Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase

(2015) Ryan T. VanderLinden et al.   MOLECULAR CELL

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of the interaction of Ubp6 with the 26S proteasome

(2015) Antje Aufderheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of the anaphase-promoting complex: A single-molecule study

(2015) Y. Lu et al.   SCIENCE

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Paradigms of protein degradation by the proteasome

(2014) Tomonao Inobe et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dss1 Is a 26S Proteasome Ubiquitin Receptor

(2014) Konstantinos Paraskevopoulos et al.   MOLECULAR CELL

Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

(2014) Evan J Worden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

(2014) G. R. Pathare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

(2014) P. Unverdorben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

(2014) Robin van der Lee et al.   Cell Reports

Localization of the regulatory particle subunit Sem1 in the 26S proteasome

(2013) Stefan Bohn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Slippery Substrates Impair ATP-dependent Protease Function by Slowing Unfolding

(2013) Daniel A. Kraut   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome

(2013) Andreas Peth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the 26S proteasome with ATP- S bound provides insights into the mechanism of nucleotide-dependent substrate translocation

(2013) P. Sledz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling the Long-Held Secrets of the 26S Proteasome

(2013) Friedrich Förster et al.   STRUCTURE

Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid

(2013) Eric Estrin et al.   STRUCTURE

Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates

(2013) M. Min et al.   Open Biology

A common ancestry for BAP1 and Uch37 regulators

(2012) Luis Sanchez-Pulido et al.   BIOINFORMATICS

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

Rpn1 and Rpn2 Coordinate Ubiquitin Processing Factors at Proteasome

(2012) Rina Rosenzweig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPINE-D: Accurate Prediction of Short and Long Disordered Regions by a Single Neural-Network Based Method

(2012) Tuo Zhang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini

(2012) Dikla Berko et al.   MOLECULAR CELL

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex

(2012) Andrew M Ellisdon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

(2012) E. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly

(2012) M.-B. Barrault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

(2012) K. Lasker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-atomic resolution structural model of the yeast 26S proteasome

(2012) F. Beck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings

(2012) Jun He et al.   STRUCTURE

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1

(2011) Tara A Gomez et al.   BMC BIOLOGY

Defining the geometry of the two-component proteasome degron

(2011) Tomonao Inobe et al.   Nature Chemical Biology

An asymmetric interface between the regulatory and core particles of the proteasome

(2011) Geng Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together

(2011) G. R. Pathare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying Conformational States of Macromolecules by Eigen-Analysis of Resampled Cryo-EM Images

(2011) Pawel A. Penczek et al.   STRUCTURE

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation

(2011) Christian Heinen et al.   Nature Communications

Rad23 escapes degradation because it lacks a proteasome initiation region

(2011) Susan Fishbain et al.   Nature Communications

Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis

(2010) Antony S. Fatimababy et al.   FEBS Journal

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation

(2010) Andreas Peth et al.   MOLECULAR CELL

Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

(2010) Kianoush Sadre-Bazzaz et al.   MOLECULAR CELL

Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2

(2010) Xiang Chen et al.   MOLECULAR CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation

(2010) Tao Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution

(2010) S. Bohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, function and mechanism of the anaphase promoting complex (APC/C)

(2010) David Barford   QUARTERLY REVIEWS OF BIOPHYSICS

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome

(2009) Friedrich Förster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation

(2009) Anne Beskow et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Activity of the N-Terminal Substrate Recognition Domains in Proteasomal ATPases

(2009) Sergej Djuranovic et al.   MOLECULAR CELL

Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor

(2009) Daoning Zhang et al.   MOLECULAR CELL

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insights into the molecular architecture of the 26S proteasome

(2009) S. Nickell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraproteasomal Rpn10 Restricts Access of the Polyubiquitin-Binding Protein Dsk2 to Proteasome

(2008) Yulia Matiuhin et al.   MOLECULAR CELL

Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

(2008) Julius Rabl et al.   MOLECULAR CELL

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

(2008) Patrick Schreiner et al.   NATURE

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE

Substrate selection by the proteasome during degradation of protein complexes

(2008) Sumit Prakash et al.   Nature Chemical Biology

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY