Journal
FEBS LETTERS
Volume 589, Issue 19, Pages 2754-2762Publisher
WILEY
DOI: 10.1016/j.febslet.2015.07.050
Keywords
Arf GAP; SMAP1; SMAP2; Genetic interaction; Embryogenesis
Funding
- JSPS KAKENHI [24570159]
- Nara Women's University Intramural Grant for Project Research
- Sasakawa Scientific Research Grant from Japan Science Society
- Grants-in-Aid for Scientific Research [25114003, 25650104, 24570159] Funding Source: KAKEN
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In mammals, the small Arf GTPase-activating protein (SMAP) subfamily of An GTPase-activating proteins consists of closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes seen in single knockout mice. The present study investigated whether SMAP proteins interact genetically. We report for the first time that simultaneous loss of SMAP1 and SMAP2 promotes apoptosis in the distal region of E7.5 mouse embryos, likely resulting in embryonic lethality. Thus, at least one SMAP gene, either SMAP1 or SMAP2, is required for proper embryogenesis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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