Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ

Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change

(2015) Philip Nevin et al.   DNA REPAIR

Unique Structural Features in DNA Polymerase IV Enable Efficient Bypass of the N 2 Adduct Induced by the Nitrofurazone Antibiotic

(2015) Jithesh Kottur et al.   STRUCTURE

Conformational Dynamics of a Y-Family DNA Polymerase during Substrate Binding and Catalysis As Revealed by Interdomain Förster Resonance Energy Transfer

(2014) Brian A. Maxwell et al.   BIOCHEMISTRY

Recent Insight into the Kinetic Mechanisms and Conformational Dynamics of Y-Family DNA Polymerases

(2014) Brian A. Maxwell et al.   BIOCHEMISTRY

Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants

(2014) Linlin Zhao et al.   FEBS Journal

Conformational Analysis of Processivity Clamps in Solution Demonstrates that Tertiary Structure Does Not Correlate with Protein Dynamics

(2014) Jing Fang et al.   STRUCTURE

Unraveling structural mechanisms of allosteric drug action

(2014) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules

(2013) Lars Konermann et al.   ANALYTICAL CHEMISTRY

Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily

(2013) Jason M. Walsh et al.   DNA REPAIR

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

(2013) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Translesion DNA Polymerases

(2013) M. F. Goodman et al.   Cold Spring Harbor Perspectives in Biology

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

(2012) Andrew J. Percy et al.   ANALYTICA CHIMICA ACTA

Effects of non-catalytic, distal amino acid residues on activity ofE. coliDinB (DNA polymerase IV)

(2012) Jason M. Walsh et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA Lesion Alters Global Conformational Dynamics of Y-family DNA Polymerase during Catalysis

(2012) Brian A. Maxwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion Specificity

(2012) Ryan C. Wilson et al.   STRUCTURE

Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting

(2012) B. Ram Prasad et al.   THEORETICAL CHEMISTRY ACCOUNTS

Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms

(2012) Tamar Schlick et al.   THEORETICAL CHEMISTRY ACCOUNTS

Discrimination against the Cytosine Analog tC by Escherichia coli DNA Polymerase IV DinB

(2011) Jason M. Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis

(2011) Ajay Ummat et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural diversity of the Y-family DNA polymerases

(2010) Janice D. Pata   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structural basis for the suppression of skin cancers by DNA polymerase η

(2010) Timothy D. Silverstein et al.   NATURE

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Stress-Induced  -Lactam Antibiotic Resistance Mutation and Sequences of Stationary-Phase Mutations in the Escherichia coli Chromosome

(2009) J. F. Petrosino et al.   JOURNAL OF BACTERIOLOGY

Structure-Function Relationships in Miscoding bySulfolobus solfataricusDNA Polymerase Dpo4

(2009) Huidong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase κ Opposite the 7,8-Dihydro-8-oxo-2′-deoxyguanosine Adduct

(2009) Adriana Irimia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Changes during Nucleotide Selection bySulfolobus solfataricusDNA Polymerase Dpo4

(2009) Robert L. Eoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of N2-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W

(2009) Huidong Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS

(2009) Scott J. Geromanos et al.   PROTEOMICS

Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis

(2009) Cuiling Xu et al.   PLOS BIOLOGY

High-Speed and High-Resolution UPLC Separation at Zero Degrees Celsius

(2008) Thomas E. Wales et al.   ANALYTICAL CHEMISTRY

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH

Role for DNA Polymerase κ in the Processing ofN2-N2-Guanine Interstrand Cross-links

(2008) Irina G. Minko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Analysis of Correct Nucleotide Insertion by a Y-family DNA Polymerase Reveals Conformational Changes Both Prior to and following Phosphodiester Bond Formation as Detected by Tryptophan Fluorescence

(2008) Jeff W. Beckman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snapshots of a Y-Family DNA Polymerase in Replication: Substrate-induced Conformational Transitions and Implications for Fidelity of Dpo4

(2008) Jimson H. Wong et al.   JOURNAL OF MOLECULAR BIOLOGY

The N-clasp of human DNA polymerase κ promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions

(2008) Lei Jia et al.   NUCLEIC ACIDS RESEARCH

Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

(2008) B. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA