Active ERK2 is sufficient to mediate growth arrest and differentiation signaling

Phosphorylation releases constraints to domain motion in ERK2

(2014) Y. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

MEK1/2 Overactivation Can Promote Growth Arrest by Mediating ERK1/2-Dependent Phosphorylation of p70S6K

(2013) Jean-Philippe Guégan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase

(2013) P.-K. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Importance of Domain Closure for the Autoactivation of ERK2

(2011) Daniel Barr et al.   BIOCHEMISTRY

The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells

(2011) Seung-Keun Hong et al.   EXPERIMENTAL CELL RESEARCH

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

(2009) Seung-Keun Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation

(2009) Diane S. Lidke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

(2009) Alice C Fan et al.   NATURE MEDICINE

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

(2008) Laure Voisin et al.   BMC CANCER

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB

(2008) Sabine I. Mayer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases

(2008) Vered Levin-Salomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY