Article
Plant Sciences
JiSuk Lee, YoungChul Bae, Nam Jae Kim, Sabina Lim, Young-Mi Kim, Jinwoong Kim, Young-Won Chin
Summary: This study demonstrated the anti-rheumatic effects of A. jaluense tubers in acute and chronic arthritis rats, showing potential for controlling pain and psychiatric symptoms associated with arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yang Baoqi, Ma Dan, Zhao Xingxing, Zhu Xueqing, Wang Yajing, Xu Ke, Zhang Liyun
Summary: Rheumatoid arthritis (RA) is an autoimmune disease associated with multiple comorbidities, including cardiovascular disease, lung cancer, lymphoma, infection, and osteoporosis. Therapeutic drugs for RA can have both beneficial and harmful effects on cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qiao Zhou, Qi Zhang, Kaiwen Wang, Ting Huang, Shaoping Deng, Yi Wang, Chunming Cheng
Summary: This review summarizes the risk of HBV reactivation and medication management plan for HBV carriers, especially rheumatic patients, during rheumatoid therapy. It also provides preventive strategies for HBV reactivation-induced liver diseases, particularly cirrhosis and hepatocellular carcinoma (HCC). These findings are significant for developing treatments for rheumatic patients and preventing HBV-related liver diseases.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Miren Uriarte Ecenarro, Daniel Useros, Aranzazu Alfranca, Reyes Tejedor, Isidoro Gonzalez-Alvaro, Rosario Garcia-Vicuna
Summary: An early and sustained reduction in ACPA titers associated with the decline in disease activity can be detected in seropositive early arthritis patients under non-protocolized treatment.
Article
Plant Sciences
JiSuk Lee, Sabina Lim
Summary: The study showed that Cassia twigs have chronic anti-inflammatory and anti-arthritic effects, reducing the paw edema volume in rats with chronic arthritis. Additionally, it exhibited analgesic effects by restoring paw withdrawal latency and suppressing vocalization scores in arthritis rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Yuqiang Luo, Yu Shen, Luye Zong, Jiankun Xie, Liangfang Dai, Xiangdong Luo
Summary: The aim of this study was to test the anti-rheumatic arthritis effects of Rhododendron molle G. Don leaf extract in arthritis rats and inflammatory RAW 264.7 cells. The results showed that the three polar extracts from the leaves of R. molle could significantly inhibit swelling and reduce arthritis index in rats, as well as inhibit pro-inflammatory factors and inflammatory mediator in vitro. These findings provide a basis for the clinical application of R. molle.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Tamseela Mumtaz, Ayesha Tahir, Maham Almas Tariq, Muhammad Amir Iqbal
Summary: The comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients was evaluated in this study. While methotrexate had more harmful effects on the heart, blood vessels, and kidneys, leflunomide posed a greater risk to the liver.
Article
Immunology
Ivan Arias de la Rosa, Alejandro Escudero-Contreras, Miriam Ruiz-Ponce, Cristobal Roman-Rodriguez, Carlos Perez-Sanchez, Maria del Carmen Abalos-Aguilera, Rafaela Ortega-Castro, Juan Alcaide, Mora Murri, Pilar Font, Jerusalem Calvo-Gutierrez, Maria Luque-Tevar, Alejandra Maria Patino-Trives, Rocio Guzman-Ruiz, Maria del Mar Malagon, Francisco Jose Tinahones, Eduardo Collantes-Estevez, Chary Lopez-Pedrera, Nuria Barbarroja
Summary: Obesity may not directly impact disease activity in rheumatoid arthritis patients, but the induction of arthritis can lead to transcriptomic changes in adipose tissue under obesity conditions. Treatment with hydroxychloroquine can reduce weight and insulin resistance, with beneficial metabolic effects in adipose tissue.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bilal Aslam, Asif Hussain, Muhammad Naeem Faisal, Zia-ud-Din Sindhu, Rifat Ullah Khan, Ibrahim A. Alhidary, Shabana Naz, Vincenzo Tufarelli
Summary: This study evaluated the anti-arthritic activity of curcumin and meloxicam co-loaded PLGA nanoparticles in adjuvant-induced arthritic rats. The results showed that the co-loaded nanoparticles significantly reduced paw swelling and arthritic score, restored body weight and immune organ index, and attenuated serum inflammatory markers and oxidative stress parameters in the arthritic rats. Furthermore, the nanoparticles modulated cytokine expressions and exhibited a greater anti-arthritic effect compared to the individual compounds.
Article
Immunology
Salma T. T. Rafik, Teshreen M. M. Zeitoun, Thanaa I. I. Shalaby, Mervat K. K. Barakat, Cherine A. A. Ismail
Summary: The conjugation of methotrexate to gold nanoparticles showed significant improvement in rheumatoid vascular dysfunction, highlighting the potential of nanoparticles-targeted drug delivery system in treating cardiovascular diseases in rheumatoid arthritis patients.
INFLAMMOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hong Ki Min, Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee
Summary: Targeting specific pathologic pro-inflammatory cytokines or related molecules with biologic disease-modifying anti-rheumatic drugs (bDMARDs), such as monoclonal antibodies, has shown excellent therapeutic effects in various forms of inflammatory arthritis. These bDMARDs can target different pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-17A, IL-6, and IL-23/12, and control the inflammatory response by targeting specific cell-surface molecules. The therapeutic efficacy and adverse events of bDMARDs vary among different types of inflammatory arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sehan Kim, Jong Hee Sun, Hongsik Kim, Hee Kyung Kim, Yaewon Yang, Jun Su Lee, In Ah Choi, Hye Sook Han
Summary: This article reports a case of immune checkpoint inhibitor-induced psoriatic arthritis in a gastric cancer patient, in which multiple medications were used during the treatment process and achieved good disease control. This suggests that some severe immune-related adverse events may require disease-modifying anti-rheumatic drugs and long-term management.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Biochemistry & Molecular Biology
Selvakumar Murugesan, Venkatesan Srinivasan, Dinesh Kumar Lakshmanan, Meenakshi R. Venkateswaran, Sasidharan Jayabal, M. S. A. Muthukumar Nadar, Arunkumar Kathiravan, Mariadoss Asha Jhonsi, Sivasudha Thilagar, Sureshkumar Periyasamy
Summary: The study investigated the anti-rheumatic potential of thymol-CDs conjugates in treating rheumatoid arthritis, showing significant reduction in arthritis symptoms in rats and promising antioxidant activity.
Article
Pharmacology & Pharmacy
Perle Totoson, Celian Peyronnel, Aurore Quirie, Martin Pedard, Marina Cefis, Laurent Bermont, Anne Prigent-Tessier, Clement Prati, Maude Tournier, Daniel Wendling, Christine Marie, Celine Demougeot
Summary: The study found that Tofacitinib significantly improved arthritis symptoms, lowered cholesterol levels, and improved endothelial function in AIA rat models. Tofacitinib also helped increase BDNF levels and reduce cardiovascular risk.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Fabio Cacciapaglia, Francesca Romana Spinelli, Elena Bartoloni, Serena Bugatti, Gian Luca Erre, Marco Fornaro, Andreina Manfredi, Matteo Piga, Garifallia Sakellariou, Ombretta Viapiana, Fabiola Atzeni, Elisa Gremese
Summary: Rheumatoid arthritis (RA) and diabetes mellitus (DM) are both influenced by inflammation and have a connection in their development and progression. This study compared the characteristics of RA patients with and without DM, and found that DM patients were older and more commonly male, with higher BMI and weight. They were also less likely to use glucocorticoids and had higher HAQ scores. The study also highlighted the association between DM and RA, suggesting systemic inflammation as an underlying condition for both diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Perle Totoson, Celian Peyronnel, Aurore Quirie, Martin Pedard, Marina Cefis, Laurent Bermont, Anne Prigent-Tessier, Clement Prati, Maude Tournier, Daniel Wendling, Christine Marie, Celine Demougeot
Summary: The study found that Tofacitinib significantly improved arthritis symptoms, lowered cholesterol levels, and improved endothelial function in AIA rat models. Tofacitinib also helped increase BDNF levels and reduce cardiovascular risk.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Letter
Rheumatology
Frank Verhoeven, Quentin Lepiller, Sophie Hecquet, Clement Prati, Daniel Wendling
Article
Multidisciplinary Sciences
Marina Cefis, Remi Chaney, Aurore Quirie, Clelia Santini, Christine Marie, Philippe Garnier, Anne Prigent-Tessier
Summary: The study provided a comprehensive analysis of BDNF localization in rat skeletal muscle, revealing endothelial cells as an important yet unexplored source of BDNF. This endothelial BDNF expression likely explains the higher levels of BDNF in oxidative muscle compared to glycolytic muscle despite the higher expression of BDNF by type II fibers.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Remi Chaney, Philippe Garnier, Aurore Quirie, Alain Martin, Anne Prigent-Tessier, Christine Marie
Summary: The study found that electrically induced bilateral hindlimb contraction selectively increased cerebral blood flow in specific regions, but no changes were observed in cognition-related brain areas, indicating that electric stimulation does not support flow-dependent neuroplasticity in cognitive function.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Rheumatology
Frank Verhoeven, Mickael Chouk, Clementine Delcourt, Clement Prati, Daniel Wendling
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, Research & Experimental
Celian Peyronnel, Perle Totoson, Helene Martin, Celine Demougeot
Summary: Rheumatoid arthritis (RA) is associated with excessive cardiovascular mortality due to premature atherosclerosis, with endothelial activation (EA) playing a key role. EA involves loss of vascular integrity, expression of leucocyte adhesion molecules, transition to a prothrombotic phenotype, cytokine production, shedding of membrane microparticles, and recruitment of endothelial progenitor cells. Circulating markers of EA may serve as potential biomarkers for vascular pathology and cardiovascular (CV) risk. This review presents the biology of EA, analyzes available data on EA markers in RA in relation to vascular pathology and CV events, discusses their relevance as biomarkers of CV risk, and proposes future directions.
Article
Pharmacology & Pharmacy
Usana Chatturong, Helene Martin, Perle Totoson, Kornkanok Ingkaninan, Prapapan Temkitthawon, Saharat Sermsenaphorn, Thanachon Somarin, Adchatawut Konsue, M. Paul Gleeson, Celine Demougeot, Krongkarn Chootip
Summary: Phosphodiesterase 5 (PDE5) inhibitors have good selectivity and vasorelaxant effects in the treatment of pulmonary arterial hypertension (PAH). This study identified two quinazoline analogues with potential as new drugs for PAH, as they showed good PDE5 inhibitory activity and selectivity for the pulmonary vasculature. These compounds enhance nitric oxide-sGC-cGMP pathway and inhibit calcium, leading to a relaxant effect on the pulmonary arteries.
VASCULAR PHARMACOLOGY
(2022)
Editorial Material
Rheumatology
Frank Verhoeven, Daniel Wendling, Clement Prati
Summary: In this article, we discuss the role of artificial intelligence (AI) in scientific article writing, particularly editorials. We asked chatGPT to write an editorial on how AI could potentially replace rheumatologists in editorial writing for the Annals of Rheumatic Diseases. chatGPT's response was diplomatic, acknowledging AI as a tool to assist, rather than replace, rheumatologists. While AI is already used in medicine, particularly in image analysis, its potential applications in scientific article writing could rapidly aid or replace rheumatologists. We also explore the ethical aspects and future role of rheumatologists.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Frederic Meyer, Daniel Wendling, Celine Demougeot, Clement Prati, Frank Verhoeven
Summary: This review summarizes the effects of cytokines on intestinal permeability. It was found that certain cytokines can increase intestinal permeability and lead to excessive inflammatory response. However, the effects of different cytokines may vary under different conditions.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Olivier Fakih, Maxime Desmarets, Berenger Martin, Clement Prati, Daniel Wendling, Elisabeth Monnet, Frank Verhoeven
Summary: This study aimed to investigate the incidence of major adverse cardiovascular events (MACEs) in French patients benefiting from the Long-term Illness scheme (LTI) for ankylosing spondylitis (AS) and the effect of different treatments on MACE occurrence. The results showed that NSAIDs and anti-TNF treatment were associated with a lower risk of MACE occurrence, while anti-IL17 treatment was not.
Article
Rheumatology
C. Peyronnel, P. Totoson, V Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, F. Verhoeven, H. Martin, C. Demougeot
Summary: This study found that local cryotherapy can reduce systemic endothelial activation, immune cell infiltration, and endothelial dysfunction in rats with adjuvant-induced arthritis. This effect may be achieved by reducing circulating levels of IL-17A.
ARTHRITIS RESEARCH & THERAPY
(2022)
