Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandra M. M. Filipkowski, Suman Kundu, Svetlana K. K. Eden, Charles W. W. Alcorn, Amy C. C. Justice, Kaku A. A. So-Armah, Hilary A. A. Tindle, Quinn S. S. Wells, Joshua A. A. Beckman, Matthew S. S. Freiberg, Aaron W. W. Aday
Summary: Compared with individuals without HIV infection, people with HIV do not have an increased risk of abdominal aortic aneurysm (AAA), but the risk of AAA is increased among HIV-infected individuals with low CD4+ T-cell counts or high HIV viral load.
Review
Cardiac & Cardiovascular Systems
Jinping Lin, Shuwei Chen, Yuanyuan Yao, Min Yan
Summary: Abdominal aortic aneurysms (AAAs) are characterized by localized dilation of the abdominal aorta and can lead to serious consequences. Aortic rupture is the main complication and causes a significant number of deaths worldwide. Despite progress in research, there is still a lack of established methods to slow down aneurysm dilation, emphasizing the need for further studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Li Yin, Eric William Kent, Bowen Wang
Summary: Abdominal aortic aneurysm (AAA) is a common focal dilation of the aorta in the elderly population, which can lead to aneurysmal rupture with a mortality rate of around 80%. Despite increased screening efforts, there is currently no cure to halt the expansion of AAA, partly due to incomplete understanding of its pathogenesis. Animal models provide valuable insights into AAA pathophysiology, but no single experimental model fully captures the complexity of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Leander Gaarde Melin, Julie Husted Dall, Jes S. Lindholt, Lasse B. Steffensen, Hans Christian Beck, Sophie L. Elkrog, Pernille D. Clausen, Lars Melholt Rasmussen, Jane Stubbe
Summary: Supplementation of cycloastragenol can inhibit the progression of abdominal aortic aneurysm, possibly by reducing matrix metalloprotease-2 activity, preserving elastin, and reducing calcification.
Article
Biochemistry & Molecular Biology
Juri Lieberg, Anders Wanhainen, Aigar Ottas, Mare Vahi, Mihkel Zilmer, Ursel Soomets, Martin Bjorck, Jaak Kals
Summary: The study found that levels of certain amino acids and phosphatidylcholines were significantly lower in abdominal aortic aneurysm (AAA) patients compared to controls. However, there were no significant differences in metabolites distinguishing between patients with slow or fast growth of the AAA.
Review
Immunology
Zhen Yuan, Yi Lu, Jia Wei, Jiaqi Wu, Jin Yang, Zhejun Cai
Summary: Abdominal aortic aneurysms (AAAs) are local dilations of the infrarenal segment of aortas, with inflammation playing a central role in their development. In addition to inflammatory cells like T cells, macrophages, and neutrophils, special structures such as inflammasomes and neutrophil extracellular traps are investigated for their roles in aneurysm formation. Understanding the impacts and interactions of these inflammatory cells and structures is crucial for developing new screening and pharmacological interventions for AAA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Spanos, Konstantinos Dakis, Alexandros Brodis, George Kouvelos
Summary: This systematic review evaluates predictive imaging factors for AAA growth, with an emphasis on aneurysm diameter as the most studied factor associated with expansion and the main indication for intervention. The study highlights the importance of appropriate diagnostic modalities in identifying aneurysms with rapid growth and higher rupture risk. Future perspectives may include computed mathematical models for AAA growth prediction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chongyang Zhang, Hongmei Zhao, Yujun Cai, Jian Xiong, Amy Mohan, Danfei Lou, Hangchuan Shi, Yishuai Zhang, Xiaochun Long, Jing Wang, Chen Yan
Summary: Abdominal aortic aneurysm (AAA) is a common vascular pathology in elderly males characterized by aorta dilation, with cyclic nucleotide phosphodiesterase 1C (PDE1C) playing a critical role in its development. PDE1C elevation contributes to SMC senescence and AAA progression, potentially serving as a therapeutic target against aortic aneurysms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Gediminas Vaitenas, Valerija Mosenko, Austeja Racyte, Karolis Medelis, Arminas Skrebunas, Tomas Baltrunas
Summary: Recently, AAA volume measurement has been proposed as a potentially valuable surveillance method in situations when diameter measurement might fail. This systematic review analyzed previous studies comparing AAA diameter and volume measurements. The majority of the included studies favored volume measurement, but the heterogeneity of methodologies and lack of standardized protocols hindered the interpretation of results.
Article
Cardiac & Cardiovascular Systems
Joscha Mulorz, Joshua M. Spin, Pireyatharsheny Mulorz, Markus Wagenhaeuser, Alicia Deng, Karin Mattern, Yae H. Rhee, Kensuke Toyama, Matti Adam, Hubert Schelzig, Lars Maegdefessel, Philip S. Tsao
Summary: This study found that the use of electronic cigarettes with nicotine can increase the development of abdominal aortic aneurysms and induce inflammation and the production of reactive oxygen species in the body. Furthermore, the study identified a key factor, CHI3L1/Chil1, in the development of e-cigarette-induced aneurysms.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Daniel Koerfer, Philipp Erhart, Susanne Dihlmann, Maani Hakimi, Dittmar Boeckler, Andreas S. Peters
Summary: The aim of this study was to investigate the histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms. The study found that IL-1 beta was significantly more present in the tunica media in patients with multiple arterial aneurysms compared to those with a single AAA. This suggests that inflammatory processes play a role in aneurysm formation in patients with multiple arterial aneurysms.
Article
Medicine, General & Internal
Amelie L. Behrens, Susanne Dihlmann, Caspar Grond-Ginsbach, Andreas S. Peters, Bernhard Dorweiler, Dittmar Boeckler, Philipp Erhart
Summary: Gene expression profiling reveals the involvement of chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components in the development and progression of abdominal aortic aneurysms (AAA). The study shows heterogeneous gene expression patterns within the AAA vascular wall. Single biopsy investigations do not provide a comprehensive characterization of the activated molecular processes in AAA disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Lei Wang, Dong Yang, Ying-Hou Wang, Xi Li, Hong-Ming Gao, Jun-Yuan Lv, Lei Wang, Shi-Jie Xin
Article
Medicine, Research & Experimental
Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Dong Yang, Chuanjiang Wang, Yingwei Luo, Xuan Li, Qingbin Song, Jian Zhang, Shijie Xin
Review
Biotechnology & Applied Microbiology
Lun Wang, Dong Yang, Jun-Yuan Lv, Dan Yu, Shi-Jie Xin
ONCOTARGETS AND THERAPY
(2017)
Article
Biochemistry & Molecular Biology
Junyuan Lv, Lei Wang, Jin Zhang, Ruoran Lin, Lun Wang, Weifeng Sun, Huize Wu, Shijie Xin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Xiao Yang, Yu Lun, Han Jiang, Xun Liu, Zhiquan Duan, Shijie Xin, Jian Zhang
Article
Oncology
Xun Liu, Shuai Zhang, Qinwei Gang, Shikai Shen, Jian Zhang, Yu Lun, Dongdong Xu, Zhiquan Duan, Shijie Xin
Article
Nursing
Yu Yang, Xinhua Hu, Qiang Zhang, Hui Cao, Jun Li, Junpeng Wang, Yang Shao, Shijie Xin
INTERNATIONAL JOURNAL OF NURSING PRACTICE
(2016)
Editorial Material
Surgery
Yu Lun, Han Jiang, Dongdong Xu, Shijie Xin, Jian Zhang
JOURNAL OF VASCULAR SURGERY
(2018)
Article
Surgery
Yu Lun, Han Jiang, Yuchen Jing, Shijie Xin, Jian Zhang
JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES
(2018)
Article
Surgery
Yu Lun, Han Jiang, Shijie Xin, Jian Zhang
ANNALS OF VASCULAR SURGERY
(2017)
Article
Cardiac & Cardiovascular Systems
Guangxin Li, Lingfeng Qin, Lei Wang, Xuan Li, Alexander W. Caulk, Jian Zhang, Pei-Yu Chen, Shijie Xin
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)
Article
Surgery
X. Yu, Y. Huang, Q. Guo, Y. Wang, H. Mao, Y. Zhao
BRITISH JOURNAL OF SURGERY
(2017)
Article
Medicine, Research & Experimental
Chen Sun, Shu Lin, Lin Zhao, Shijie Xin
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)