Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable

Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes

(2015) Hajime J. Yuasa et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

(2014) Georgios Pantouris et al.   AMINO ACIDS

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation

(2014) Richard Metz et al.   INTERNATIONAL IMMUNOLOGY

IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis

(2014) L. M. F. Merlo et al.   JOURNAL OF IMMUNOLOGY

New Insights into IDO Biology in Bacterial and Viral Infections

(2014) Susanne V. Schmidt et al.   Frontiers in Immunology

The Role of Placental Tryptophan Catabolism

(2014) Peter Sedlmayr et al.   Frontiers in Immunology

Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota

(2013) Hajime J. Yuasa et al.   FUNGAL GENETICS AND BIOLOGY

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Indoleamine 2,3-dioxygenase: From catalyst to signaling function

(2012) Francesca Fallarino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

How is the distal pocket of a heme protein optimized for binding of tryptophan?

(2012) Nishma Chauhan et al.   FEBS Journal

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

(2011) David Meininger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

(2011) Juliana Croitoru-Lamoury et al.   PLoS One

1-l-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-d-methyltryptophan

(2010) Hajime J. Yuasa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases

(2009) Hajime J. Yuasa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Substrate−Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76

(2009) Dipanwita Batabyal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties

(2008) Christopher J. D. Austin et al.   AMINO ACIDS

The Role of Serine 167 in Human Indoleamine 2,3-Dioxygenase: A Comparison with Tryptophan 2,3-Dioxygenase†

(2008) Nishma Chauhan et al.   BIOCHEMISTRY

A Kinetic, Spectroscopic, and Redox Study of Human Tryptophan 2,3-Dioxygenase†

(2008) Jaswir Basran et al.   BIOCHEMISTRY

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY