The impacts of pretreatment circulating eosinophils and basophils on prognosis of stage ?-? colorectal cancer

AimThe effects of circulating eosinophils and basophils on cancer survival are unclear. Here, we aimed to explore the impacts of eosinophils and basophils on prognosis of stage I-III colorectal cancer (CRC) patients. MethodsFrom February 2003 to March 2013, 569 stage I-III CRC patients were enrolled in this retrospective study. The associations between pretreatment circulating eosinophils, basophils and CRC overall survival (OS), disease-free survival (DFS) were investigated. Moreover, the prognostic value of combined eosinophils/basophils and neutrophil to lymphocyte ratio (NLR)/platelet to lymphocyte ratio (PLR) was investigated. ResultsKaplan-Meier methods showed the associations of eosinophils<0.095 x 10(9)/L and shorter OS (P<0.0001), eosinophils<0.055 x 10(9)/L and shorter DFS (P<0.0001), basophils<0.015 x 10(9)/L and shorter OS (P=0.001), basophils<0.015 x 10(9)/L and shorter DFS (P=0.005). Cox regression model showed that eosinophils<0.095 x 10(9)/L (hazard ratio [HR], 1.723; 95% confidence intervals [CI]=1.177-2.523) and basophils<0.015 x 10(9)/L (HR, 1.714; 95% CI=1.152-2.548) were independent prognostic factors for OS, and eosinophils<0.055 x 10(9)/L (HR, 2.309; 95% CI=1.587-3.361) and basophils<0.015 x 10(9)/L (HR, 1.397; 95% CI=1.003-1.945) were independent prognostic factors for DFS, respectively. The combined eosinophil-PLR (HR, 2.611; 95% CI=1.328-5.130) and basophil-PLR (HR, 2.520; 95% CI=1.240-5.123) were the independent prognostic factors for OS. The combined eosinophil-NLR (HR, 2.770; 95% CI=1.528-5.019) and eosinophil-PLR (HR, 4.788; 95% CI=2.458-9.329) were the independent prognostic factors for DFS. ConclusionPretreatment circulating eosinophils<0.095 x 10(9)/L/0.055 x 10(9)/L and circulating basophils<0.015 x 10(9)/L have significant impacts on prognosis of stage I-III CRC patients.