Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ruiping Zhai, Yingchen Lyu, Mengshan Ni, Fangfang Kong, Chengrun Du, Chaosu Hu, Hongmei Ying
Summary: The study aims to identify factors predicting the risk of hypothyroidism in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy (IMRT). The findings suggest that younger age, female gender, and small thyroid volume are the most important factors predicting hypothyroidism risk. Thyroid volume Vt40 is a key parameter in predicting the risk of hypothyroidism after IMRT in nasopharyngeal carcinoma patients.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Qiaojuan Guo, Nan Xiao, Hanchuan Xu, Jingfeng Zong, Youping Xiao, Tianzhu Lu, Yun Xu, Bingyi Wang, Bijuan Chen, Jianji Pan, Shaojun Lin
Summary: This study investigated the feasibility of level Ib sparing in selected nasopharyngeal carcinoma patients during intensity-modulated radiation therapy based on the International Guideline. The results showed that level Ib-sparing IMRT is safe and feasible for patients who meet certain criteria.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Otorhinolaryngology
Jing-Jin Weng, Jia-Zhang Wei, Min Li, Le-Ping Ning, Fei Liu, Yun-Zhong Wei, Wei-Ming Xiong, Ben-Jian Zhang, Jin-Long Lu, He Jiang, Qiu-Tian Lu, Shen-Hong Qu
Summary: This study aimed to investigate the effect of hypothyroidism and thyroxine replacement therapy on the prognosis of nasopharyngeal carcinoma (NPC) patients. The results showed that patients with hypothyroidism had better survival rates. Hypothyroidism was identified as a positive independent prognostic factor. Thyroxine replacement therapy did not negatively affect the survival rates of these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Xixi Liu, Bian Wu, Jing Huang, You Qin, Zhanjie Zhang, Liangliang Shi, Xiaohua Hong, Qian Ding, Gang Peng, Kunyu Yang
Summary: This study aims to identify tumor factors associated with in-field failure in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). The results showed that in-field failure was the major pattern of recurrence in NPC patients. Large tumor volume, nonkeratinizing differentiated carcinoma, and cervical nodal necrosis were independent tumor factors associated with in-field failure.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Otorhinolaryngology
Yongyuan Xue, Guoping Li, Tao Xie, Hongyang Xu, Tianrui Xu, Zhengfei Li, Lixiu Zhu, Xin Li, Zhiyao Li, Wei Xiong
Summary: This study systematically reviewed the significance of concurrent chemoradiotherapy for stage II nasopharyngeal cancer. The results showed that in the era of intensity-modulated radiotherapy, concurrent chemoradiotherapy and radiotherapy alone have the same survival benefits and concurrent chemoradiotherapy increases acute hematological toxicity. Subgroup analysis showed that for people with N1 nasopharyngeal cancer at risk of distant metastases, concurrent chemoradiotherapy and radiotherapy alone also had equal survival benefits.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Multidisciplinary Sciences
Xi Wang, Shunlan Wang, Yang Cao, Chunqiao Li, Caishan Fang, Weiping He, Zhuming Guo
Summary: This study compared the clinicopathologic characteristics of second primary squamous cell carcinoma (SPSCC) in nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiotherapy (IMRT) and radiotherapy (RT). Among 49,021 patients treated with definitive RT, 15 male patients with SPSCC were identified after IMRT, and 23 male patients were identified after RT. The study found that receiving IMRT was associated with an increased risk of SPSCC, with a shorter latency compared to RT. There was no significant correlation between receiving IMRT and the survival of SPSCC. A follow-up protocol should be designed for NPC patients with IMRT, especially in the first three years.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Ronald Wihal Oei, Yingchen Lyu, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying
Summary: This study compared the performance of the Cox proportional hazards model (CPH) with the conditional survival forest (CSF) and DeepSurv, two state-of-the-art machine learning algorithms, for disease progression prediction in nasopharyngeal carcinoma (NPC), with DeepSurv achieving the best performance.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Otorhinolaryngology
Yingchen Lyu, Mengshan Ni, Ruiping Zhai, Fangfang Kong, Chengrun Du, Chaosu Hu, Hongmei Ying
Summary: The study found that elderly NPC patients aged 70 years and above receiving IMRT treatment had good survival rates, with significantly less acute toxicities compared to patients undergoing chemoradiotherapy. Age has a significant impact on survival outcomes, with older age predicting poorer prognosis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Ying-peng Peng, Qiao-dan Liu, Yu-jing Lin, Shun-li Peng, Rong Wang, Xi-wei Xu, Wei Wei, Gui-hua Zhong, Yu-ling Zhou, Ya-qin Zhang, Ye Liu, Si-yang Wang, Hai-yu Hong, Zhi-gang Liu
Summary: Head and neck neuroendocrine carcinomas (NECs) occurring as second cancers after radical radiotherapy for nasopharyngeal carcinoma (NPC) are rarely reported. Our study focused on investigating the clinicopathological characteristics and genomic landscape of these second head and neck NECs. The research found common genetic mutations and potential signaling pathways in these second cancers, indicating a need for further study on optimal treatment approaches in future clinical trials.
RADIATION ONCOLOGY
(2021)
Article
Otorhinolaryngology
Robert W. Gao, David M. Routman, William S. Harmsen, Sasha Ebrahimi, Robert L. Foote, Daniel J. Ma, Michelle Neben-Wittich, Lisa A. McGee, Samir H. Patel, Eric J. Moore, Garret W. Choby, Kendall K. Tasche, Katharine A. Price, Mauricio E. Gamez, Scott C. Lester
Summary: This study evaluates radiotherapy techniques and recurrence patterns for adenoid cystic carcinoma of the head and neck. It found that modern conformal radiotherapy leads to low rates of recurrence. Higher doses of radiation (>60 Gy) postoperatively and definitively (70 Gy) may improve treatment outcomes. Selective omission of elective nodal treatment may be considered for suitable patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Medicine, General & Internal
Xiaoshuang Niu, Fen Xue, Peiyao Liu, Chaosu Hu, Xiayun He
Summary: Satisfactory locoregional control was achieved in nasopharyngeal carcinoma patients with T1-2N0-3M0 stage treated with intensity-modulated radiotherapy (IMRT). Distant metastasis was the main cause of treatment failure, and N2-3 disease was the main adverse prognostic factor. Additionally, the occurrence of second primary tumor negatively impacted overall survival in NPC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Letter
Oncology
Ka Man Cheung, Therese Yue Man Tsui, James Chung Hang Chow
Article
Nuclear Science & Technology
Muhammad Isa Khan, Jalil ur Rehman, Muhammad Afzal, James C. L. Chow
Summary: This study analyzed the dosimetric differences between IMRT and VMAT techniques in lung cancer treatment planning at different isocenters. IMRT showed superior target dose coverage and higher maximum dose compared to other VMAT techniques, while DA-VMAT resulted in higher doses to the contralateral lung.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Biology
Duong Thanh Tai, Luong Thi Oanh, Pham Hoai Phuong, Abdelmoneim Sulieman, Fouad A. Abolaban, Hiba Omer, James C. L. Chow
Summary: Comparing the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique with 3D conformal radiation therapy (3D-CRT) for head and neck treatment, it was found that JO-IMRT can improve dose coverage to the target, enhance conformity index (CI) and homogeneity index (HI), and reduce doses to the parotid glands.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Chemistry, Multidisciplinary
James C. L. Chow
Article
Dentistry, Oral Surgery & Medicine
Carlos Aparicio, Waldemar D. Polido, James Chow, Ruben Davo, Bilal Al-Nawas
Summary: This study reports the effectiveness of two new site-specific zygomatic implants placed using the zygoma anatomy-guided approach (ZAGA). The results show a 100% implant/prosthesis survival rate and low complication levels, suggesting that ZAGA-Flat and ZAGA-Round zygomatic implants are viable treatment options for restoring atrophic maxillae.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
H. S. Chung, J. C. H. Chow, M. H. C. Lam, R. K. C. Ngan, K. H. Wong
Summary: The clinicopathological features and survival outcomes of young females with breast cancer in Hong Kong were reviewed. The study found that these patients tend to have aggressive breast cancer and are often diagnosed at an advanced stage. Breast cancer in young Asian women may have different phenotypes compared to Western patients, emphasizing the need for further investigation. Multimodality treatments may improve survival rates.
HONG KONG JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Tsui, K. M. Cheung, J. C. H. Chow, K. H. Wong
Summary: The study found that age, patient performance status, and pre-treatment hemoglobin level are important factors in predicting 90-day mortality in HNC patients, and the Adult Comorbidity Evaluation-27 (ACE-27) and the Taipei Medical University-concurrent chemoradiotherapy Mortality Predictor Score (TMU-CCRT) are the most significant predictors.
HONG KONG JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Y. H. Chuk, J. C. H. Chow, K. M. Cheung, S. S. W. Tse, R. C. Y. Ho, H. Y. Wong, A. N. Y. Yeung, K. H. Wong
Summary: The study found that pretreatment lymphocyte count is closely associated with prognosis in cervical cancer patients in Hong Kong, with lower lymphocyte count being linked to poorer overall survival and recurrence-free survival.
HONG KONG JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Gagliardi, Rob H. C. Chen, Himani S. Boury, Mathieu Albert, James Chow, Ralph DaCosta, Michael Hoffman, Behrang Keshavarz, Pia Kontos, Jenny Liu, Mary Pat McAndrews, Stephanie Protze
Summary: This study aimed to identify and prioritize measures for assessing research quality and impact. The results identified 50 measures organized in 8 domains. It also found a set of measures that comply with the principles of DORA.
Article
Chemistry, Analytical
James C. L. Chow, Sama Jubran
Summary: This study examined the depth dose enhancement in orthovoltage nanoparticle-enhanced radiotherapy for skin treatment by investigating the impact of various photon beam energies, nanoparticle materials, and nanoparticle concentrations. It found that gold nanoparticles outperformed other materials, with a maximum dose enhancement ratio of 3.77 at a concentration of 40 mg/mL. Increasing nanoparticle concentration and decreasing photon beam energy were found to increase dose enhancement.
Article
Multidisciplinary Sciences
Hoang T. P. Hung, Pham Nhu Tuyen, Duong Thanh Tai, Ha Quoc Long, Abdelmoneim Sulieman, Hiba Omer, Nissren Tamam, Abdullah Almujally, James C. L. Chow, Ting-Yim Lee
Summary: This study aims to estimate the occupational radiation exposure for workers in the Nuclear Medicine department of Da Nang Oncology Hospital, Vietnam. The results showed that the average radiation exposure in 2020 and 2021 was below the occupational dose limits, although some measurement points revealed higher doses. It is recommended to continuously monitor the occupational dose to ensure the safety of personnel in the department.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Article
Health Policy & Services
Himani Boury, Mathieu Albert, Robert H. C. Chen, James C. L. Chow, Ralph DaCosta, Michael M. Hoffman, Behrang Keshavarz, Pia Kontos, Mary Pat McAndrews, Stephanie Protze, Anna R. Gagliardi
Summary: Based on prior research, we have identified and prioritized ten research performance assessment measures that comply with the San Francisco Declaration on Research Assessment. This study explores potential barriers to implementing and adopting these measures, given the shift away from assessment based on Journal Impact Factor.
HEALTH RESEARCH POLICY AND SYSTEMS
(2023)
Editorial Material
Computer Science, Artificial Intelligence
James C. L. Chow, Leslie Sanders, Kay Li
FRONTIERS IN ARTIFICIAL INTELLIGENCE
(2023)
Article
Computer Science, Artificial Intelligence
James C. L. Chow, Leslie Sanders, Kay Li
Summary: This article introduces a method to develop an educational chatbot for disseminating information on radiotherapy. The chatbot is designed with a dialogue tree and layered structure, incorporating features such as natural language processing. It provides humanlike communication and accurate responses to users, and requires regular updates to provide new content and features.
Article
Health Care Sciences & Services
Nathanael Rebelo, Leslie Sanders, Kay Li, James C. L. Chow
Summary: This study developed a virtual assistant, a chatbot, using artificial intelligence and machine learning techniques to comprehensively and accurately explain the radiation treatment process, providing information for patients, their families, and the general public. The bot performed well in testing and can be improved and updated based on user feedback.
JMIR FORMATIVE RESEARCH
(2022)