Journal
ARTIFICIAL ORGANS
Volume 42, Issue 7, Pages 746-755Publisher
WILEY
DOI: 10.1111/aor.13111
Keywords
Blood damage index; Blood cell dynamics; Cell activation; Hemolysis; Lattice Boltzmann method; Immersed boundary method
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Funding
- NO For-schungs- und Bildungsges.m.b.H. (NFB) [LSC13-024]
- Slovak Research and Development Agency [APVV-15-0751]
- Ministry of Education, Science, Research and Sport of the Slovak Republic [VEGA 1/0643/17]
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Shear-induced hemolysis is a major concern in the design and optimization of blood-contacting devices. Even with a small amount of mechanical stress, inflammatory reactions can be triggered in the cells. Blood damage is typically estimated using continuum fluid dynamics simulations. In this study, we report a novel cell damage index (CDI) obtained by simulations on the single-cell level in a lattice Boltzmann fluid flow. The change of the cell surface area gives important information on mechanical stress of individual cells as well as for whole blood. We are using predefined basic channel designs to analyze and compare the newly developed CDI to the conventional blood damage calculations in very weak shear stress scenarios. The CDI can incorporate both volume fraction and channel geometry information into a single quantitative value for the characterization of flow in artificial chambers.
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