Simulated microgravity disrupts intestinal homeostasis and increases colitis susceptibility

Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space

(2015) E.G. Novoselova et al.   IMMUNOBIOLOGY

An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro

(2014) Nabarun Chakraborty et al.   BMC GENOMICS

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

(2014) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal microbiota regulates T cell fate decision in the gut

(2014) Yukihiro Furusawa et al.   Seminars in Immunopathology

Modulation of immune development and function by intestinal microbiota

(2014) Agnieszka M. Kabat et al.   TRENDS IN IMMUNOLOGY

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease

(2014) Xiao-Rong Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity

(2014) C. Girardi et al.   Biomed Research International

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

The Role of Polymorphonuclear Leukocyte Trafficking in the Perpetuation of Inflammation During Inflammatory Bowel Disease

(2013) Jennifer C. Brazil et al.   INFLAMMATORY BOWEL DISEASES

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Effect of Simulated Microgravity on E. coli K12 MG1655 Growth and Gene Expression

(2013) Kotakonda Arunasri et al.   PLoS One

Spaceflight Influences both Mucosal and Peripheral Cytokine Production in PTN-Tg and Wild Type Mice

(2013) Justin L. McCarville et al.   PLoS One

Changes of Cytokines during a Spaceflight Analog - a 45-Day Head-Down Bed Rest

(2013) Xi Xu et al.   PLoS One

Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis

(2013) Jamie S. Foster et al.   Scientific Reports

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

21 Days head-down bed rest induces weakening of cell-mediated immunity – Some spaceflight findings confirmed in a ground-based analog

(2012) Jens Kelsen et al.   CYTOKINE

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Immune System Dysregulation Occurs During Short Duration Spaceflight On Board the Space Shuttle

(2012) Brian Crucian et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

The Impact of Long-Term Exposure to Space Environment on Adult Mammalian Organisms: A Study on Mouse Thyroid and Testis

(2012) Maria Angela Masini et al.   PLoS One

Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation

(2012) Yu Zhou et al.   PLoS One

Skin Manifestations of Inflammatory Bowel Disease

(2012) Brian L. Huang et al.   Frontiers in Physiology

IL-1 family cytokines trigger sterile inflammatory disease

(2012) John R. Lukens et al.   Frontiers in Immunology

Monocyte Phenotype and Cytokine Production Profiles Are Dysregulated by Short-Duration Spaceflight

(2011) Brian Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota

(2011) Samah O Noor et al.   BMC GASTROENTEROLOGY

Simulated Microgravity Affects Growth of Escherichia coli and Recombinant β-d-Glucuronidase Production

(2009) Liang Xiang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?

(2009) Nathan Guéguinou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune system dysregulation during spaceflight: clinical risk for exploration-class missions

(2009) Brian Crucian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune System Dysregulation Following Short- vs Long-Duration Spaceflight

(2008) Brian E. Crucian et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Effect of Spaceflight on Ability of Monocytes To Respond to Endotoxins of Gram-Negative Bacteria

(2008) I. Kaur et al.   Clinical and Vaccine Immunology