Article
Oncology
Mathilde Barrau, Khawla Maoui, Bertrand Le Roy, Xavier Roblin, Patrick Mismetti, Jean-Marc Phelip, Nicolas Williet
Summary: Early VTE is a strong prognostic factor in advanced PDAC, occurring in about one in 10 patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michal Zabczyk, Joanna Natorska, Anetta Undas
Summary: FXIII is crucial in the modulation of fibrin clot properties in patients with VTE, impacting clot structure and function. FXIII activity is significantly reduced in acute PE and DVT patients, but gradually increases after the acute phase. Reduced FXIII activity is associated with impaired clot permeability and hypofibrinolysis in acute PE patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Noel C. Chan, Jeffrey I. Weitz
Summary: This review discusses the role of FXI and FXII in the pathogenesis of venous thromboembolism, explains why FXI is a better target, and describes the potential advantages of FXI inhibitors over currently available anticoagulants. It also provides an overview of the FXI inhibitors under development and their potential in addressing unmet needs in venous thromboembolism management.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Louisa Goumidi, Florian Thibord, Kerri L. Wiggins, Ruifang Li-Gao, Mickael R. Brown, Astrid van Hylckama Vlieg, Joan-Carles Souto, Jose-Manuel Soria, Manal Ibrahim-Kosta, Noemie Saut, Delphine Daian, Robert Olaso, Philippe Amouyel, Stephanie Debette, Anne Boland, Pascal Bailly, Alanna C. Morrison, Denis O. Mook-Kanamori, Jean-Francois Deleuze, Andrew Johnson, Paul S. de Vries, Maria Sabater-Lleal, Jacques Chiaroni, Nicholas L. Smith, Frits R. Rosendaal, Daniel Chasman, David-Alexandre Tregouet, Pierre-Emmanuel Morange
Summary: Genetic risk score analysis is commonly used to predict individual risk for complex diseases. In the case of venous thrombosis, it is recommended to use 4 SNPs to assess the impact of the ABO locus on risk, as different haplotypes have varying associations with VT risk. Further research is needed to fully understand the biological effects of the ABO locus on cardiovascular traits.
Article
Hematology
Julie Jaffray, Maua Mosha, Brian Branchford, Neil A. Goldenberg, Michael Silvey, Stacy E. Croteau, John H. Fargo, James D. Cooper, Nihal Bakeer, Amy Stillings, Emily Krava, Guy Young, Ernest K. Amankwah
Summary: This study aimed to identify factors associated with catheter-related thrombosis (CRT) in children with hospital-acquired venous thromboembolism (HA-VTE). The findings showed that participants with peripherally inserted central catheters, CVCs inserted in the femoral vein, multiple CVCs, and CVC malfunction had increased odds of developing CRT compared to non-CRT. Therefore, prevention efforts should focus on modifying the type of CVC, insertion location, and/or number of CVCs placed to reduce the incidence of CRT.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James Giles, Jordan Amar, Nils Henninger, Marwa Elnazeir, Ava Liberman, Khadean Moncrieffe, Jenny Rotblat, Richa Sharma, Yee Cheng, Adeel S. Zubair, Alexis Simpkins, Grace Li, Justin Kung, Dezaray Perez, Mirjam R. Heldner, Adrian Scutelnic, Rascha Von Martial, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo J. Aparicio, Jennifer A. Frontera, Lindsey Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman ElJamal, Allison Chang, Shawna Cutting, Fransisca Indraswari, Adam de Havenon, Varsha Muddasani, Teddy Wu, Duncan Wilson, Amre Nouh, Daniyal Asad, Abid Qureshi, Justin Moore, Pooja Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian MacGrory, Martin Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James Siegler, Scott Kamen, Siyuan Yu, Christopher Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Psychogios, Ronald Alvarado-Dyer, Tareq Kass-Hout, Shyam Prabhakaran, Tristan Honda, David Liebeskind, Karen Furie, Shadi Yaghi
Summary: This study aimed to identify predictors of recurrent venous thrombosis in patients with CVT. The study found that Black race, history of VTE, and the presence of one or more positive antiphospholipid antibodies were associated with recurrent venous thrombosis among patients with CVT.
Article
Hematology
Alison Michels, Laura L. Swystun, Courtney N. Dwyer, Orla Rawley, Kate Nesbitt, Colleen Notley, David Lillicrap
Summary: The study aimed to assess the influence of stabilin-2 on deep vein thrombosis and characterize the prothrombotic phenotype associated with stabilin-2 deficiency in a mouse model. The results showed that stabilin-2 deficiency was associated with larger and qualitatively distinct venous thrombi, involving elevated levels of neutrophil extracellular trap-releasing leukocytes and increased procoagulant activity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Roberto Zambelli, Banne Nemeth, Carolina E. Touw, Frits R. Rosendaal, Suely M. Rezende, Suzanne C. Cannegieter
Summary: The study found that patients with thrombophilia have an increased risk of VTE after orthopedic surgery. Identifying and providing individualized thromboprophylactic treatment for these patients can efficiently reduce the risk of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Joakim K. Sejrup, Birgitte G. Tondel, Vania M. Morelli, Maja-Lisa Lochen, Inger Njolstad, Ellisiv B. Mathiesen, Tom Wilsgaard, John-Bjarne Hansen, Sigrid K. Braekkan
Summary: This study investigates the combined effect of myocardial infarction (MI) and obesity on the risk of venous thromboembolism (VTE).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Hematology
Gordon Lowe, Olivia Wu, Astrid van Hylckama Vlieg, Aaron Folsom, Frits Rosendaal, Mark Woodward
Summary: This study conducted a systematic review and meta-analysis to investigate the associations between plasma factor VIII (FVIII) and factor IX (FIX) levels and the risk of venous thromboembolism (VTE). The results showed significant correlations between elevated FVIII and FIX levels in the population and increased risk of VTE. Levels above the 90th percentile had two times the risk for FIX, three times the risk for FVIII, and almost five times the risk for both elevated FVIII and FIX levels.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Moriaki Inoko, Tomohisa Tada, Po -Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Takao Kato, Koh Ono, Takeshi Kimura, COMMAND VTE Registry Investigators
Summary: This study found that cancer was the most common cause of long-term mortality in patients with venous thrombo-embolism, while non-cardiovascular non-cancer death became the most common cause among patients without active cancer.
THROMBOSIS RESEARCH
(2022)
Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Article
Oncology
Yuan Zhang, Zhongyue Shi, Jiawen Yi, Jin Zhao, Shu Zhang, Wei Feng, Min Zhu, Bin Hu, Yuhui Zhang
Summary: Patients with primary lung adenocarcinoma are at increased risk of venous thromboembolism, especially during the perioperative process and hospitalization. Presence of micropapillary features and older age are positively associated with an increased risk of VTE.
Article
Hematology
Magdolna Nagy, Alejandro Pallares Robles, Mayken Visser, Thomas Koeck, Vincent ten Cate, Arina J. ten Cate-Hoek, Stephan Schwers, Stefan Heitmeier, Hugo ten Cate, Philipp S. Wild, Henri M. H. Spronk
Summary: This study found that FXIa levels were elevated in patients with acute VTE and were associated with recurrent VTE, suggesting a significant risk contribution of FXI activation to VTE. The findings support the use of FXIa inhibition in the setting of acute VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Dongwon Yoon, Han Eol Jeong, Sohee Park, Seng Chan You, Soo-Mee Bang, Ju-Young Shin
Summary: This study investigated the feasibility of using real-world evidence studies to complement randomized controlled trials in patients with venous thromboembolism. The results showed that real-world study populations differed in demographic characteristics compared to trial populations, with RWE populations being older, more female, and having a higher prevalence of active cancer. The emulated estimates for effectiveness outcomes generally showed superior effectiveness of NOACs, while safety outcomes were consistent with corresponding RCTs in most cases.
Article
Behavioral Sciences
Rupert Staebler, Dorian Patzkewitsch, Sven Reese, Michael Erhard, Sandrina Hartmannsgruber
Summary: The study on pig behavior in a near-natural habitat showed that pigs did not exhibit a biphasic activity rhythm. The pigs spent more time on activities like foraging and locomotion as the day progressed, with rooting behavior being essential. Resting made up a significant portion of their time. Recommendations were provided for modern, animal-friendly pig management practices based on the study's findings.
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH
(2022)
Article
Multidisciplinary Sciences
Alexandra Blaeske, Angela Schwarzer, Magdalena Ebner, Hendrikje Gerbig, Sven Reese, Michael Erhard, Anna-Caroline Woehr
Summary: German retailers offer a wide range of pet accessories, but many of them are not suitable for pet husbandry and can negatively impact animal welfare. This study evaluated various pet products, such as cages, running wheels, and hay racks, and found that a majority of them were unsuitable and detrimental to animal well-being. There were also significant shortcomings in product declarations, making it difficult for pet owners to make informed choices. The study suggests implementing mandatory product declarations and voluntary certifications to ensure the availability of properly declared and welfare-compliant pet accessories.
Article
Veterinary Sciences
Patrick Wagmeister, Stephanie Steigmeier-Raith, Sven Reese, Andrea Meyer-Lindenberg
Summary: Regardless of the size of the dogs, unilateral hindlimb lameness leads to the same compensatory changes, including anterior and lateral shift of the body mass center. The affected groups showed higher load on the non-affected body half and lower weight-bearing on the affected limb compared to the corresponding healthy groups.
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2022)
Article
Veterinary Sciences
Fabienne Sprissler, Prapaporn Jongwattanapisan, Supol Luengyosluechakul, Rosama Pusoonthornthum, Sven Reese, Michele Bergmann, Katrin Hartmann
Summary: This study investigated the prevalence of FIV and FeLV infection in healthy outdoor cats in North, Northeast and Central Thailand and evaluated the associated risk factors. The results showed that the prevalence of FIV and FeLV infections was lower than expected in these regions, and there were no significant risk factors for FeLV infection. However, the risk of FIV infection increased with age.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Ulrike Flock, Stine Fischer, Jasmin Weeger, Sven Reese, Beate Walter
Summary: AMH determination can serve as a useful diagnostic tool for diagnosing ORS in cats, with significantly higher serum concentrations in cats with ORS compared to spayed and sexually intact cats. Cats with ORS showed no heat signs after surgical removal of ovarian tissue.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Veterinary Sciences
Sandra U. Mall, Stephanie Steigmeier-Raith, Sven Reese, Andrea Meyer-Lindenberg
Summary: The objective of this study was to collect kinetic gait reference data of growing dogs during walking and trotting gait, describe their development, and investigate the weight support pattern over time. Significant differences in gait and breed comparisons were found, with growing dogs showing a forelimb-dominated gait.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2022)
Review
Veterinary Sciences
Britta M. Fischer, Walter Brehm, Sven Reese, Richard J. McMullen
Summary: Equine recurrent uveitis (ERU) is the leading cause of blindness in horses worldwide, with significant physical, emotional, and economic impact on horses and their owners. This article reviews the proposed causes of ERU and discusses its complex relationship with leptospirosis. It also evaluates clinical signs, classifications, and diagnostic testing, and compares current treatment options in terms of nonrecurrence rates, visual outcomes, and complication rates.
EQUINE VETERINARY EDUCATION
(2023)
Article
Agriculture, Dairy & Animal Science
Angela Schwarzer, Elke Rauch, Michael Erhard, Sven Reese, Paul Schmidt, Shana Bergmann, Christina Plattner, Anne Kaesberg, Helen Louton
Summary: This study aims to deduce the occurrence of severe feather pecking and cannibalism in laying hens through individual and visual plumage scoring under practical conditions. The results show correlations between plumage scoring and feather pecking rate, neck-back plumage score, and cannibalism score. The study concludes that plumage scoring can serve as a reliable indicator of severe feather pecking, and visual scoring can provide a good evaluation of flock plumage condition.
Article
Microbiology
Matthias Eddicks, Roland Maurer, Pauline Deffner, Lina Eddicks, Wolfgang Sipos, Sven Reese, Vojislav Cvjetkovic, Roman Krejci, Tanja Opriessnig, Mathias Ritzmann, Robert Fux
Summary: PCV2 is highly prevalent in suckling piglets, while the prevalence of PCV3 is low. Vaccination of sows against PCV2 can protect piglets from PCV2 infection, and vaccination of sows against PRRSV can protect piglets from PCV3 infection. This indicates the importance of factors affecting the infection of PCV2 and PCV3 in pig populations.
Article
Veterinary Sciences
Sandra R. P. Kriechbaumer, Konrad Jurina, Franziska Wielaender, Henning C. Schenk, Tanja A. Steinberg, Sven Reese, Gesine Buhmann, Stefanie Doerfelt, Heidrun Potschka, Andrea Fischer
Summary: This study compares the effectiveness and tolerability of two add-on treatment strategies in dogs with drug-resistant idiopathic epilepsy. The results show low overall success rates and highlight the need for further research on better pharmacological and non-pharmacological treatment strategies for dogs with drug-resistant epilepsy.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Ulrike Flock, Sven Reese, Christiane Otzdorff, Ruth Klein, Beate Walter
Summary: Studies have shown the usefulness of anti-Mullerian hormone (AMH) as a diagnostic tool for determining the castration status or diagnosing ovarian remnant syndrome in cats and dogs. However, the secretion pattern of AMH during the estrous cycle in female cats has not been investigated. This study examined seven healthy sexually intact female cats and found high variations in AMH levels among individuals and within the same cat's heat cycles. Remarkably high AMH concentrations were observed in younger queens during their first estrous cycles and also during anestrus. Further studies are needed to understand the reasons for these high AMH concentrations, especially in young queens.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Florian Boehmer, Katharina Erber, Anja Ewringmann, Ruth Klein, Sven Reese, Christine Boehmer, Andrea Meyer-Lindenberg, Beate Walter
Summary: This study aimed to investigate the value of serum AMH concentrations in distinguishing spayed from intact female rabbits and its relationship with pseudopregnancy and ovarian follicle numbers. The results showed that a single determination of serum AMH concentrations was adequate to differentiate spayed from intact female rabbits, and the follicular or luteal phase did not significantly influence the measured serum AMH concentrations.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Multidisciplinary Sciences
Kristin Delank, Sven Reese, Michael Erhard, Anna-Caroline Woehr
Summary: This study aimed to investigate the midterm effects of weaning on foals' welfare by evaluating their behavioral changes and fecal cortisol metabolite levels. Ten foals were observed for three weeks after weaning, and it was found that they displayed a hormonal stress response with increased cortisol metabolite levels. Their body posture distribution also shifted from mainly moving to mainly standing. The foals showed an expected behavioral development and cortisol metabolite changes throughout the study, but it took at least three weeks for them to acclimate to the new situation.
Article
Cardiac & Cardiovascular Systems
Manovriti Thakur, Carolina Victoria Cruz Junho, Sarah Maike Bernhard, Marc Schindewolf, Heidi Noels, Yvonne Doering
Summary: Arterial and venous thrombosis are significant causes of morbidity and mortality worldwide. The association between thrombotic complications and cardiovascular and chronic inflammatory diseases is well-established. Inflammation and immunothrombosis, the initiation of thrombotic events, are gaining attention, but still not fully understood. However, the clinical relevance of aberrant immunothrombosis, known as thromboinflammation, is evident by the increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. This review focuses on the interrelationships and functions between NETs and other mediators in cardiovascular disease, as well as neutrophil phenotype, function, and NET formation in chronic kidney disease. Therapeutic targeting of NETs-induced immunothrombosis is also discussed as a potential intervention beyond current treatment options.
CIRCULATION RESEARCH
(2023)
Article
Microbiology
Matthias Eddicks, Julia Gruendl, Annika Seifert, Lina Eddicks, Sven Reese, Robert Tabeling, Hanny Swam, Katrin Strutzberg-Minder, Mathias Ritzmann, Robert Fux
Summary: In this study, the occurrence of coinfections with SMEDI-associated pathogens and the associations among these pathogens were investigated. The results showed a significant association between the detection of Leptospira spp. and PCV2 coinfection, while PCV3 positivity resulted in a reduced probability of detecting PCV2 in fetuses. Fetal maceration was associated with the detection of Leptospira spp., while mummification, reduced crown-rump length, and bodyweight of fetuses were significantly associated with PPV1 and PCV2 coinfection.