Article
Biochemistry & Molecular Biology
Azza A. A. Attia, Jehan M. M. Sorour, Neama A. A. Mohamed, Tagreed T. T. Mansour, Rasha A. A. Al-Eisa, Nahla S. S. El-Shenawy
Summary: This study aimed to investigate the protective role of vitamin E in improving cardiotoxicity induced by cyclophosphamide in rats. The results showed that vitamin E could attenuate the elevation of cardiac markers, increase in lipid profiles, reduction in antioxidant enzyme activities, and increase in lipid peroxidation. In addition, vitamin E was found to improve the histopathological alterations caused by cyclophosphamide.
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Biochemistry & Molecular Biology
Priscila Ortega, Hector Aguilar Vitorino, Shadaesha Green, Flavia P. Zanotto, J. Sook Chung, Renata G. Moreira
Summary: The study showed that in crabs from highly contaminated areas, cadmium bioaccumulation, oxidative stress, and hormone levels were higher compared to those from lightly contaminated areas, while the transcripts of crustacean hyperglycemic hormone and molt-inhibiting hormone decreased.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Fisheries
Hongjian Lu, Zhengxi Wang, Yuwei Ding, Xue Feng, Chunxian Zhao, Linghan Chen, Weizhi Yao, Dan Xi, Mei Fu
Summary: In this study, it was found that injection of Calcein (CAL) could induce a strong oxidative stress response in juvenile silver carp. The severity of oxidative stress was correlated with the injection dose and time after injection. Higher CAL doses could lead to greater toxicity in the fish. When using CAL for fluorescent labeling, the injection dose should be restricted to 25 mg/kg or less and the injected fish should be reared for at least 16 days.
Article
Environmental Sciences
Javaid Akhter Bhat, Masroor Ahmad Bhat, Dyaaaldin Abdalmegeed, Deyue Yu, Jian Chen, Andrzej Bajguz, Ajaz Ahmad, Parvaiz Ahmad
Summary: The study demonstrated that the combined application of Fe2O3-NPs and CA had a better alleviating effect on As toxicity in soybean. Fe2O3-NPs and CA significantly reversed As-induced growth inhibition and oxidative stress responses, partially reducing the production of MDA and H2O2.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Applied
Rouhollah Karimi, Khaled Gavili-Kilaneh, Ali Khadivi
Summary: The foliar spray of methyl jasmonate (MJ), especially at 100 μM, was found to alleviate the negative effects of salinity stress in grapes by improving physiological parameters, reducing ion leakage, increasing photosynthetic pigments and proline content, and enhancing antioxidant enzyme activity.
Article
Environmental Sciences
Abdul Qader, Kanwal Rehman, Muhammad Sajid Hamid Akash
Summary: This study investigated the impairment of lipid metabolism induced by lead (Pb) and its amelioration through plant-based therapeutic interventions. Pb-induced hepatotoxicity disrupted the normal levels of antioxidant enzymes, leading to lipid peroxidation. Additionally, Pb toxicity altered the regulation of hormones involved in the synthesis of HMG-CoA reductase, resulting in abnormal levels of serum cholesterol and other lipid molecules. The administration of resveratrol effectively treated Pb toxicity. Overall, this study demonstrated the therapeutic effect of resveratrol in improving Pb-induced lipid metabolism impairment by using vitamin C as a standard intervention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yanqiang Li, Jun Wang, Zhongkang Yang, Guangde Li, Zhongwen Zhang, Dexin Zhang, Hui Sun
Summary: This study investigated the effects of MTBE on oxidative stress and DNA damage in earthworms. The results showed that MTBE treatment increased the production of ROS, activated defense enzymes, and caused DNA damage in earthworms. This study contributes to a better understanding of the impact of MTBE on soil invertebrate animals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Malachy N. O. Ajima, Kundan Kumar, Nalini Poojary, Pramod K. Pandey
Summary: This study found that long-term exposure to diclofenac can induce oxidative imbalance, neurotoxicity, and alterations in gene expression related to stress in Nile tilapia. These biomarkers could potentially be used to monitor the adverse effects of pharmaceuticals on organisms in aquatic ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Akansha Srivastav, Deepak Ganjewala, Rakesh Kumar Singhal, Vishnu D. Rajput, Tatiana Minkina, Marina Voloshina, Sudhakar Srivastava, Manoj Shrivastava
Summary: The study found that zinc accumulation increased in wheat and maize with increasing doses of zinc oxide nanoparticles, leading to slight increases in plant length, biomass, and photosynthetic pigments. Antioxidant enzyme activity increased at lower concentrations, but declined at higher levels.
Article
Plant Sciences
F. A. S. Hassan, E. Ali, A. Gaber, M. Fetouh, R. Mazrou
Summary: Chitosan nanoparticles show significant potential in mitigating salt stress in Catharanthus roseus by activating antioxidant defense system and inducing gene expression, leading to higher alkaloid accumulation and better protection against salinity stress.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
E. F. Ali, A. M. El-Shehawi, O. H. M. Ibrahim, E. Y. Abdul-Hafeez, M. M. Moussa, F. A. S. Hassan
Summary: This study is the first to demonstrate the use of chitosan nanoparticles (CSNPs) in alleviating drought stress of Catharanthus roseus by enhancing antioxidant potential and gene expression related to alkaloid biosynthesis. CSNPs increased proline accumulation and the activity of catalase (CAT) and ascorbate peroxidase (APX), reducing drought-induced oxidative stress and preserving membrane integrity. Additionally, CSNPs led to increased alkaloid accumulation and upregulated gene expression associated with alkaloid biosynthesis under drought stress.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Lilian Nogueira, Danielly Garcia, Fernando Sanzi Cortez, Camilo Dias Seabra Pereira, Eduardo Alves de Almeida
Summary: This study assessed the combined effect of hypoxia and diesel exposure on biochemical parameters of Perna perna mussels. The results showed that cycles of air exposure and reoxygenation caused oxidative stress and antioxidant modulation in both the gills and digestive glands. The presence of diesel in water apparently enhanced the mussels' capacity to avoid lipid peroxidation under hypoxia and reoxygenation stress.
MARINE POLLUTION BULLETIN
(2023)
Article
Engineering, Environmental
Xiaole Wang, Jingwen Zhang, Yu Liu, Chengbo Lu, Kaixuan Hou, Yunchen Huang, Albert Juhasz, Lusheng Zhu, Zhongkun Du, Bing Li
Summary: The toxicity of florasulam to larvae and adult zebrafish was studied. It was found that florasulam caused DNA damage in larvae but inhibited apoptosis in adult zebrafish. The toxicity of florasulam was concentration-dependent and increased with longer exposure time.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Wagner Antonio Tamagno, Carla Alves, Aline Pompermaier, Andre Luis Veneral, Joao Antonio Duarte Lampugnani, Gustavo Kellermann Reolon, Leonardo Jose Gil Barcellos
Summary: Pyrethroids prallethrin and transfluthrin are commonly used insecticides, but their safety in animals and humans is a concern. The impact of these insecticides on the antioxidant system of zebrafish was studied, and it was found that different tissues showed different responses. The muscle tissue was the most affected, potentially related to neurodegenerative conditions. In the brain, the compounds inactivated the first line of enzymatic antioxidant defense but the second line compensated, avoiding cellular damage. The gill tissue did not show lipid damage but had a significant effect on heme group formation.
ENVIRONMENTAL POLLUTION
(2023)
Article
Public, Environmental & Occupational Health
Mirta Milic, Suzana Zunec, Vedran Micek, Vilena Kasuba, Anja Mikolic, Blanka Tariba Lovakovic, Tanja Zivkovic Semren, Ivan Pavicic, Ana Marija Marjanovic Cermak, Alica Pizent, Ana Lucic Vrdoljak, Rafael Valencia-Quintana, Juana Sanchez-Alarcon, Davor Zeljezic
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Nevenka Kopjar, Suzana Zunec, Gordana Mendas, Vedran Micek, Vilena Kasuba, Anja Mikolic, Blanka Tariba Lovakovic, Mirta Milic, Ivan Pavicic, Ana Marija Marjanovic Cermak, Alica Pizent, Ana Lucic Vrdoljak, Davor Zeljezic
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Environmental Sciences
Vilena Kasuba, Vedran Micek, Alica Pizent, Blanka Tariba Lovakovic, Davor Zeljezic, Mirta Milic, Nevenka Kopjar
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Toxicology
Goran Gajski, Marko Geric, Tanja Zivkovic Semren, Blanka Tariba Lovakovic, Visnja Orescanin, Alica Pizent
TOXICOLOGY LETTERS
(2020)
Review
Cell Biology
David R. Wallace, Yasmeen M. Taalab, Sarah Heinze, Blanka Tariba Lovakovic, Alica Pizent, Elisavet Renieri, Aristidis Tsatsakis, Ammad Ahmad Farooqi, Dragana Javorac, Milena Andjelkovic, Zorica Bulat, Biljana Antonijevic, Aleksandra Buha Djordjevic
Article
Environmental Sciences
Blanka Tariba Lovakovic, Vilena Kasuba, Anja Katic, Nevenka Kopjar, Ana Marija Marjanovic Cermak, Vedran Micek, Mirta Milic, Ivan Pavicic, Alica Pizent, Suzana Zunec, Davor Zeljezic
Article
Biochemistry & Molecular Biology
Alica Pizent, Maja Lazarus, Jelena Kovacic, Blanka Tariba Lovakovic, Irena Brcic Karaconji, Tanja Zivkovic Semren, Ankica Sekovanic, Tatjana Orct, Karmen Branovic-Cakanic, Natasa Brajenovic, Andreja Juric, Iva Miskulin, Lana Skrgatic, Sandra Stasenko, Tatjana Mioc, Jasna Jurasovic, Martina Piasek
Article
Public, Environmental & Occupational Health
Vilena Kasuba, Mirta Milic, Davor Zeljezic, Marin Mladinic, Alica Pizent, Zorana Kljakovic-Gaspic, Melita Balija, Irena Jukic
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Anja Katic, Vilena Kasuba, Nevenka Kopjar, Blanka Tariba Lovakovic, Ana Marija Marjanovic Cermak, Gordana Mendas, Vedran Micek, Mirta Milic, Ivan Pavicic, Alica Pizent, Suzana Zunec, Davor Zeljezic
Summary: Oral 28-day exposure to low doses of imidacloprid in rats resulted in detectable levels of imidacloprid in plasma and brain tissue that directly induced DNA damage, particularly in brain tissue, with slight changes in plasma oxidative stress parameters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Blanka Tariba Lovakovic, Vilena Kasuba, Ankica Sekovanic, Tatjana Orct, Antonija Jancec, Alica Pizent
Summary: The study showed that exposure to low doses of imidacloprid can lead to adverse effects on the reproductive system of male rats, affecting testicular weight, antioxidant state, DNA damage, and essential element concentrations. This suggests a need for further evaluation of the widely used insecticide for its potential biological effects.
Meeting Abstract
Toxicology
D. Rasic, A. Juric, A. Zandona, B. Tariba Lovakovic, A. Pizent, N. Kopjar, M. Katalinic, G. Kozina, A. Lucic Vrdoljak, A. Resic, I. Brcic Karaconji
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Alica Pizent, Milena Andelkovic, Blanka Tariba Lovakovic, Tanja Zivkovic Semren, Aleksandra Buha Djordjevic, Marija Gamulin, Vera Bonderovic, Miodrag Acimovic, Zorica Bulat
Summary: Higher blood Hg, SOD, and GPx levels and lower serum SH levels were found in prostate cancer patients compared to controls. Significant correlations between oxidative stress parameters and metal concentrations suggest a potential role of metal-induced oxidative stress in prostate cancer.
Article
Public, Environmental & Occupational Health
Andreja Juric, Antonio Zandona, Blanka Tariba Lovakovic, Dubravka Rasic, Alica Pizent, Goran Kozina, Maja Katalinic, Ana Lucic Vrdoljak, Irena Brcic Karaconji
Summary: This study aimed to assess the toxic effects of LSD and PCP in the human neuroblastoma cell line, and found that LSD has a greater potential for DNA damage and oxidative activity compared to PCP.
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2021)
Article
Oncology
Blanka Tariba Lovakovic, Tanja Zivkovic Semren, Toni Safner, Marija Gamulin, Majana Soce, Alica Pizent
Summary: Homeostasis disruption of element levels in men may increase susceptibility to cancer development, and environmental exposure to certain elements could contribute to the pathogenesis of testicular cancer. Differences in element levels and oxidative stress parameters were observed between men with testicular germ cell tumors (TGCT) and healthy men, with some elements like Ca, Cu, and Fe being strong predictors of illness. Additionally, patients with TGCT showed changes in serum and blood element levels with cancer progression, indicating a possible association between low-level environmental exposure to elements and cancer development. Monitoring elements concentrations during cancer treatment is important as platinum-based chemotherapeutics may further disrupt element homeostasis.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS
(2021)