Article
Environmental Sciences
Chaeeun Kim, Hyeseung Choe, Jungeun Park, Gayoung Kim, Kyeongnam Kim, Hwang-Ju Jeon, Joon-Kwan Moon, Myoung-Jin Kim, Sung-Eun Lee
Summary: Azoxystrobin (AZ) and pyraclostrobin (PY) are strobilurin fungicides that inhibit fungal mitochondrial respiration. This study used zebrafish as a model and found that pyraclostrobin had significant toxicity on embryos, causing mortality and malformations, and impacting heart development by upregulating the nppa gene. The research also suggests that strobilurin fungicides may inhibit normal heart formation and function.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Hai Lin, Fangrui Lin, Jing Yuan, Feng Cui, Jie Chen
Summary: The study found that fluxapyroxad has toxic effects on zebrafish embryos, causing abnormal spontaneous movement, malformations, decreased heartbeat, and affecting key enzyme activities such as succinate dehydrogenase. Oxidative stress, cell apoptosis, and mitochondrial damage may be the toxic mechanisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
M. Brent Hawkins, Katrin Henke, Matthew P. Harris
Summary: Changes in appendage structure are crucial in vertebrate evolution, including the transition from fins to limbs. Zebrafish mutants with supernumerary long bones in their pectoral fins were identified, caused by activating mutations in appendage patterning regulators vav2 and waslb. This pathway, required for appendage development across vertebrates, drives enhanced expression of hoxa11b and reveals a limb-like pattern ability in fins.
Article
Pharmacology & Pharmacy
Guijin Sun, Yingqiu Li
Summary: This study revealed the negative effects of butylbenzyl phthalate (BBP) on the development of zebrafish embryos. BBP exposure resulted in decreased hatching and survival rates, induced morphological abnormalities, and affected the activities of antioxidant enzymes. Transcriptome profiling analysis showed differential expression of hundreds of genes in zebrafish embryos, which were associated with various cellular processes and functions.
Article
Biochemistry & Molecular Biology
Weiwei Feng, Tong Xu, Jiali Zuo, Mengna Luo, Guanghua Mao, Yao Chen, Yangyang Ding, Emmanuel Sunday Okeke, Xiangyang Wu, Liuqing Yang
Summary: This study investigated the neurotoxicity and mechanism of low-dose TBBPA-DHEE exposure in juvenile zebrafish and identified differences in neurotoxicity susceptibility between sexes. The research found that TBBPA-DHEE significantly affected swimming behavior and brain biochemistry in zebrafish, causing brain tissue damage. The study also revealed that female zebrafish are more susceptible to TBBPA-DHEE exposure than males, and different molecular mechanisms of neurotoxicity exist between the sexes. These findings contribute to the understanding of the potential health effects of emerging environmental pollutants.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Avital Baniel, Limor Ziv, Zohar Ben-Moshe, Ofer Sarig, Janan Mohamad, Alon Peled, Gideon Rechavi, Yoav Gothilf, Eli Sprecher
Summary: Overexpression of human CARD14 in zebrafish resulted in distinct morphological and developmental changes, including a characteristic cutaneous pattern and hyperactivation of the NF-kB pathway. This study validates zebrafish as a useful system to model CARD14-associated papulosquamous diseases.
Article
Environmental Sciences
Raquel S. F. Vieira, Carlos A. S. Venancio, Luis M. Felix
Summary: The study found concentration-dependent teratogenic effects of Azoxystrobin on zebrafish embryos, but low concentrations may induce oxidative stress response. The results suggest that Azoxystrobin may pose ecotoxicological risks to non-target species.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yiming Chang, Huimin Fu, Haitao Yu, Liangang Mao, Lan Zhang, Yanning Zhang, Lizhen Zhu, Jin Yang, Xingang Liu, Hongyun Jiang
Summary: In this study, the acute toxicity, sub-lethal toxicity, and developmental toxicity of difenoconazole on zebrafish at different life stages were investigated. It was found that exposure to difenoconazole at the embryonic stage caused more severe developmental toxicity compared to other life stages. The study also revealed significant alterations in gene expression related to the steroid synthesis pathway in the F1 larvae of parents exposed to difenoconazole at the embryonic stage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Priyadharshini Manikandan, Swapnalee Sarmah, James A. Marrs
Summary: Fetal alcohol spectrum disorder (FASD) is caused by prenatal ethanol exposure. Ethanol affects gene expression and signaling pathways involved in early development, including pluripotency transcriptional gene circuit and Hedgehog signaling.
Article
Environmental Sciences
Hongyan Nie, Meiqi Pan, Juan Chen, Qing Yang, Tien-Chieh Hung, Dan Xing, Maomin Peng, Xitian Peng, Guangyu Li, Wei Yan
Summary: The presence of titanium dioxide nanoparticles (n-TiO2) significantly reduces the accumulation of azoxystrobin (AZ) and alleviates AZ-induced cardiotoxicity. The joint action of AZ and n-TiO2 leads to mitochondrial dysfunction, which may be the potential mechanism of cardiotoxicity.
Article
Environmental Sciences
Wenlong Huang, Tianjie Wu, Kusheng Wu
Summary: Ketamine, a drug commonly used as an anesthetic and also known as an illegal recreational drug, has been detected in wastewater and hospital effluents. The long-term toxicity of ketamine during early life stages in humans and rodents is still poorly understood. Zebrafish has emerged as a valuable model organism for assessing the developmental toxicity of ketamine, highlighting its potential as a biosafety model for higher vertebrates.
Article
Environmental Sciences
Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang Lu
Summary: Exposure to Sulfometuron methyl (SM) led to toxicity in zebrafish early developmental stages, affecting development, immune system, locomotor behavior, oxidative stress, and cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Xuanjun Guo, Ruihua Zhang, Qian Jin, Niannian Cao, Jingjing Shi, Xingxing Zong, Xuejun Chen, Chen Wang, Xuefeng Li, Sen Pang, Liqin Li
Summary: In this study, it was observed that azoxystrobin adversely affected courtship and aggressive behavior in zebrafish, possibly by interfering with the kisspeptin-GnIH signaling pathway. This could have profound effects on natural zebrafish populations.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Jinyuan Hu, Xu Luo, Mogellah John Panga, Clara Appiah, Vladimir Retyunskiy, Lin Zhu, Ye Zhao
Summary: Zinc pyrithione (ZPT) is widely used as an antifouling, antibacterial, and antifungal agent, but it has been shown to be toxic to marine life. However, there is limited research on the toxicity and toxicological mechanism of ZPT in the reproductive systems of aquatic organisms. Our study found that ZPT exposure caused various abnormalities in zebrafish sperm and testicular tissue, including decreased testosterone levels, sperm deformities, decreased sperm concentration and motility, and DNA damage in testicular tissue. We also identified potential mechanisms of ZPT-induced testicular injury through RNA-seq analysis of differentially expressed genes (DEGs).
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Biochemistry & Molecular Biology
Wannakarn Kitipaspallop, Siwapech Sillapaprayoon, Preecha Phuwapraisirisan, Woo-Keun Kim, Chanpen Chanchao, Wittaya Pimtong
Summary: Sesamolin, a major active compound in sesame seeds, has been found to have various pharmaceutical activities. This study showed that sesamolin may have potential toxicity to zebrafish embryonic development, including inducing malformations and reducing heart rates. It also affected genes related to angiogenesis and erythropoiesis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Fangjie Cao, Christopher L. Souders, Pengfei Li, Ondrej Adamovsky, Sen Pang, Lihong Qiu, Christopher J. Martyniuk
Article
Agriculture, Multidisciplinary
Yong-Qian Wang, Peng-Fei Zhao, Li-Feng Fan, Qiao Zhou, Zi-Yang Wang, Chao Song, Zhi-Qiang Chai, Yang Yue, Lan Huang, Zhong-Yi Wang
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2019)
Article
Engineering, Environmental
Fangjie Cao, Christopher J. Martyniuk, Peizhuo Wu, Feng Zhao, Sen Pang, Chengju Wang, Lihong Qiu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Environmental Sciences
Fangjie Cao, Christopher L. Souders, Pengfei Li, Sen Pang, Lihong Qiu, Christopher J. Martyniuk
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Environmental Sciences
Fangjie Cao, Hui Li, Feng Zhao, Peizhuo Wu, Le Qian, Lan Huang, Sen Pang, Christopher J. Martyniuk, Lihong Qiu
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Review
Genetics & Heredity
Fangjie Cao, Christopher L. Souders, Veronica Perez-Rodriguez, Christopher J. Martyniuk
FRONTIERS IN GENETICS
(2019)
Article
Environmental Sciences
Fangjie Cao, Christopher L. Souders, Pengfei Li, Sen Pang, Xuefang Liang, Lihong Qiu, Christopher J. Martyniuk
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Plant Sciences
Zi-Yang Wang, Xiao-Huang Qin, Jin-Hai Li, Li-Feng Fan, Qiao Zhou, Yong-Qian Wang, Xuan Zhao, Chao-Jie Xie, Zhong-Yi Wang, Lan Huang
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2019)
Article
Plant Sciences
Jinhai Li, Yang Yue, Ziyang Wang, Qiao Zhou, Lifeng Fan, Zhiqiang Chai, Chao Song, Hongtu Dong, Shixian Yan, Xinyu Gao, Qiang Xu, Jiepeng Yao, Zhongyi Wang, Xiaodong Wang, Peichen Hou, Lan Huang
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Agriculture, Multidisciplinary
Yang Yue, Jin-Hai Li, Li-Feng Fan, Li-Li Zhang, Peng-Fei Zhao, Qiao Zhou, Nan Wang, Zhong-Yi Wang, Lan Huang, Xue-Hui Dong
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2020)
Article
Agriculture, Multidisciplinary
Xiao-Huang Qin, Zi-Yang Wang, Jie-Peng Yao, Qiao Zhou, Peng-Fei Zhao, Zhong-Yi Wang, Lan Huang
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2020)
Article
Agriculture, Multidisciplinary
Li-Feng Fan, Zhi-Qiang Chai, Peng-Fei Zhao, Zong-Fu Tian, Shi-Qian Wen, Shao-Ming Li, Zhong-Yi Wang, Lan Huang
Summary: The study proposed a nondestructive measurement method based on the vector reflection coefficient measurement technique for in situ monitoring of the husk-covered corn kernel layer moisture in the field. By establishing quadratic regression models for the corn kernel layer moisture using impedance parameters from 51 husk-covered corn samples, it enabled nondestructive estimation of the husk-covered corn kernel layer moisture with a root mean square error of 3.53%.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2021)
Article
Engineering, Electrical & Electronic
Lifeng Fan, Zhiqiang Chai, Yongqian Wang, Ziyang Wang, Pengfei Zhao, Jinhai Li, Qiao Zhou, Xiaohuang Qin, Jiepeng Yao, Shixian Yan, Zhongyi Wang, Lan Huang
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2020)
Article
Computer Science, Artificial Intelligence
Shi-Xian Yan, Peng-Fei Zhao, Xin-Yu Gao, Qiao Zhou, Jin-Hai Li, Jie-Peng Yao, Zhi-Qiang Chai, Yang Yue, Zhong-Yi Wang, Lan Huang
Article
Computer Science, Information Systems
Zi-Yang Wang, Jin-Hai Li, Qiao Zhou, Xin-Yu Gao, Li-Feng Fan, Yong-Qian Wang, Lin Xue, Zhong-Yi Wang, Lan Huang