Journal
AQUACULTURE
Volume 490, Issue -, Pages 303-310Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquaculture.2018.02.047
Keywords
Bile acid; Soybean meal; Fishmeal; Enterohepatic circulation
Categories
Funding
- JSPS KAKENHI [JP23780217]
- Japan Fisheries Research and Education Agency
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To clarify the effect of dietary soybean meal (SBM) on bile synthesis and enterohepatic circulation in rainbow trout, three isonitrogenous and isolipidic diets; a fishmeal based diet (diet FM), a SBM based non-fishmeal diet (diet SBM) and a 1% bile acid (taurocholate) supplemented SBM diet (diet C-tau) were prepared and acute/chronic effects of the diets on the bile physiology was examined. In the acute experiment (< 24 h), fish fed the SBM based diets (diet SBM and C-tau) had higher expression levels of bile acid synthesis genes, cyp7a1-2, cyp8b11 and cyp8b1-2 in the liver compared to fish fed the FM diet. In the chronic experiment (10 weeks), fish fed the SBM and C-tau diets had significantly lower expression levels of cyp7a1 (-1 and -2), cyp8b1 (-1 and -2) genes compared with fish fed the FM diet. On the other hand, expression of bile acid synthesis inhibitor gene shp-2 was higher in fish fed the SBM diet compared with fish fed the FM and C-tau diets. Furthermore, fish fed the SBM based diet had reduced bile acid absorption rate. These data suggest that SBM up-regulates bile acid synthesis on a short-term basis, while long-term SBM administration down-regulates the bile acid synthesis and the recovery of bile through the enterohepatic circulation. The gallbladder weights of fish fed the C-tau diet were similar to those of fish fed the FM diet whereas the actual bile acid absorption ability was still suppressed in the C-tau group. This study contributes to the general knowledge of bile physiology in teleost fish under different nutritional conditions and to develop tailored and sustainable aquaculture feeds based on SBM.
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