Journal
ANTIVIRAL RESEARCH
Volume 157, Issue -, Pages 128-133Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2018.07.013
Keywords
Cytomegalovirus; Maribavir; Ganciclovir; Sirolimus; Synergism; Antagonism
Categories
Funding
- CRADA
- NIH
Ask authors/readers for more resources
The human cytomegalovirus (CMV) UL97 kinase inhibitor maribavir is in Phase III clinical trials as antiviral therapy, including use for infections refractory or resistant to standard therapy. To assess its activity in combination with approved and experimental CMV antivirals, and with the mTor inhibitor rapamycin (sirolimus), drug effects were tested by in vitro checkerboard assays and the data were analyzed using a three dimensional model based on an independent effects definition of additive interactions. Baseline virus and representative drug-resistant mutants were tested. According to the volume of synergy at 95% confidence, maribavir showed additive interactions with foscarnet, cidofovir, letermovir and GW275175X when tested against wild type and mutant viruses, strong antagonism with ganciclovir, and strong synergy with rapamycin, the latter suggesting a potentially useful therapeutic combination.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available