Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects

Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections

(2017) Matthew Sims et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection

(2016) Christopher Lucasti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

(2016) J. G. Coen van Hasselt et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects

(2015) Eric Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens

(2015) David P. Nicolau et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid

(2015) Pyry A. J. Välitalo et al.   PHARMACEUTICAL RESEARCH

Pharmacodynamics of Imipenem in Combination with β-Lactamase Inhibitor MK7655 in a Murine Thigh Model

(2014) Eleftheria Mavridou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

(2014) Timothy A. Blizzard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa

(2013) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In VitroActivity of MK-7655, a Novel β-Lactamase Inhibitor, in Combination with Imipenem against Carbapenem-Resistant Gram-Negative Bacteria

(2012) Elizabeth B. Hirsch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects

(2012) G. Chandorkar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Penetration of Meropenem into Epithelial Lining Fluid of Patients with Ventilator-Associated Pneumonia

(2011) T. P. Lodise et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Penetration of Anti-Infective Agents into PulmonaryEpithelial Lining Fluid

(2011) Keith A. Rodvold et al.   CLINICAL PHARMACOKINETICS

The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistantStaphylococcus aureus: vancomycin and linezolid

(2010) Gary E. Stein et al.   CURRENT MEDICAL RESEARCH AND OPINION

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

(2009) P. D. Lister et al.   CLINICAL MICROBIOLOGY REVIEWS