Article
Medicine, General & Internal
Johan A. Maertens, Galia Rahav, Dong-Gun Lee, Alfredo Ponce-de-Leon, Isabel Cristina Ramirez Sanchez, Nikolay Klimko, Anne Sonet, Shariq Haider, Juan Diego Velez, Issam Raad, Liang-Piu Koh, Meinolf Karthaus, Jianying Zhou, Ronen Ben-Ami, Mary R. Motyl, Seongah Han, Anjana Grandhi, Hetty Waskin
Summary: Posaconazole was non-inferior to voriconazole in terms of all-cause mortality up to day 42 in patients with invasive aspergillosis. Posaconazole was well tolerated with fewer treatment-related adverse events compared to voriconazole in the study, supporting its use as a first-line treatment for the condition.
Article
Infectious Diseases
Kelsey Jensen, Omar Abu Saleh, Supavit Chesdachai, Paul J. Jannetto, Kristin C. Mara, Zachary A. Yetmar, Christina G. Rivera
Summary: Drug level monitoring is important for evaluating dosing and effectiveness of posaconazole. High levels of posaconazole can lead to side effects. Monitoring should be done and dosage should be reduced when levels are high.
Article
Endocrinology & Metabolism
Maria Ramos-Caceres, Itziar Lamiquiz-Moneo, Ana Cenarro, Pilar Calmarza, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Jose Puzo, Jose M. Ordovas, Fernando Civeira, Martin Laclaustra
Summary: This study analyzes the relationship between triglycerides (TGs) and lipoprotein(a) (Lp(a)) concentrations. It found an inverse relationship between TG and Lp(a). Larger VLDL size, VLDLs enriched in apoE, and the apoE2/E2 genotype were associated with lower levels of Lp(a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Infectious Diseases
Parikshit S. Prayag, Shweta P. Panchakshari, Namita P. Mahalle, Surabhi Dhupad, Sampada A. Patwardhan, Sadanand S. Naik, Sharwari Narawade, Sameer Melinkeri, Amrita P. Prayag
Summary: This study retrospectively analyzed factors associated with subtherapeutic levels of the delayed release tablet of posaconazole in 164 patients. The use of proton pump inhibitors and diarrhea were found to be significantly associated with subtherapeutic levels.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Respiratory System
Saartje Verfaillie, Laurent Godinas, Isabel Spriet, Robin Vos, Geert M. Verleden
Summary: We describe a new interaction between posaconazole and flucloxacillin, which has not been reported before. The underlying mechanism is presumed to be the activation of the pregnane X receptor by flucloxacillin, which can induce cytochrome P450, uridine glucuronosyl transferase (UGT1A4) and P-glycoprotein. Caution should be exercised when combining flucloxacillin and triazoles, as interactions may result in undertreatment of invasive aspergillosis.
BMC PULMONARY MEDICINE
(2022)
Article
Microbiology
Marion Blaize, Anne-Cecile Normand, Sebastien Imbert, Abdullah M. S. Al-Hatmi, Erja Chryssanthou, Sophie Cassaing, Christine Schuttler, Lilia Hasseine, Caroline Mahinc, Damien Costa, Christine Bonnal, Stephane Ranque, Marc Sautour, Elisa Rubio, Laurence Delhaes, Arnaud Riat, Boualem Sendid, Lise Kristensen, Marcel Brandenberger, Dirk Stubbe, Sophie Brun, Renaud Piarroux, Arnaud Fekkar
Summary: The susceptibility of 182 Fusarium species isolates to five antifungal drugs was determined using the EUCAST method, showing variable results depending on the species. Comparison with the gradient concentration strip method revealed essential agreement values for voriconazole, posaconazole, isavuconazole, and amphotericin B of 17%, 91%, 83%, and 70%, respectively.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Teclegiorgis Gebremariam, Yiyou Gu, Shakti Singh, Therese Kitt, Ashraf S. Ibrahim
Summary: The combination therapy of L-AMB/isavuconazonium sulphate showed greater efficacy compared to monotherapy in immunosuppressed mice infected with the two most common causes of mucormycosis, indicating its potential as an optimal treatment strategy for human mucormycosis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Li-E Zhu, Hui-Ping Huang, Yi-Peng Cai, Yan Wang, Bao-Hua Xu, Mao-Bai Liu, Xue-Mei Wu
Summary: This study investigated the interactions between posaconazole (POS) and intravenously/orally administered cyclosporine A (CsA) in allogeneic hematopoietic stem cell transplant (HSCT) recipients. The study found that POS treatment increased blood CsA levels, and CsA doses should be adjusted based on blood CsA levels after POS initiation.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Microbiology
Abi Manesh, Emily Devasagayam, Kundakarla Bhanuprasad, Sumith K. Mathew, Rajiv Karthik, Binu S. Mathew, George M. Varghese
Summary: In this prospective study, we found that crushed delayed-release posaconazole tablets administered via nasogastric tube can achieve good plasma concentrations in patients with Rhino-orbito-cerebral mucormycosis (ROCM), leading to complete cure and survival at 3 and 6 months in 19 patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Yesenia L. L. Franco, Lais Da Silva, Nitin Charbe, Hannah Kinvig, Soyoung Kim, Rodrigo Cristofoletti
Summary: This study built PBPK models for ketoconazole and posaconazole based on in vitro biopharmaceutics and clinical data. The predictions of drug precipitation and food effect were evaluated. The forward in vitro-in vivo translation approach resulted in poor predictions of PK profiles, so a reverse translation approach was applied based on limited fitting of precipitation-related parameters to clinical data. The subsequent simulations adequately recapitulated the PK profiles for both drugs in the fasted and fed states.
PHARMACEUTICAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Tomonori Unno, Yoshiharu Araki, Shun Inagaki, Makoto Kobayashi, Masaki Ichitani, Takanobu Takihara, Hitoshi Kinugasa
Summary: Dietary fructooligosaccharides (FOS) were found to increase the plasma concentration of EGCG in rats by preventing its auto-oxidation. Treatment with FOS resulted in a dose-dependent increase in cecal lactate levels and alterations in the abundance of Lactobacillus and Collinsella. Consequently, FOS contributed to the protection of EGCG from auto-oxidation and allowed it to be absorbed into the blood circulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Kruk, Marta Szekalska, Anna Basa, Katarzyna Winnicka
Summary: Fungal infections pose a challenge in treatment due to drug-resistant fungi species, drug toxicity, and patient conditions. Thus, research is being conducted to explore new treatments such as therapeutic substances and drug delivery systems. Mucoadhesive dosage forms enhance drug bioavailability by prolonging residence time at the application site. This study aims to evaluate the impact of hypromellose on alginate microparticles containing posaconazole, in order to modify drug release and improve mucoadhesive properties for oral or vaginal application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Guoying Wang, Sally Radovick, Jessie P. Buckley, Russ Hauser, Paige L. Williams, Xiumei Hong, Colleen Pearson, William G. Adams, Xiaobin Wang
Summary: This study investigated the association between plasma insulin levels and the timing of menarche from birth to childhood. The results showed that elevated insulin concentrations at both birth and childhood were associated with earlier onset of menarche. Girls who were overweight or obese with elevated insulin levels reached menarche earlier than those with normal weight and low insulin levels. The study concludes that early screening and intervention are necessary to address the impact of elevated insulin concentrations, particularly in overweight or obese girls.
Article
Psychiatry
Sandra Domitrovic Spudic, Matea Nikolac Perkovic, Suzana Uzun, Gordana Nedic Erjavec, Oliver Kozumplik, Dubravka Svob Strac, Ninoslav Mimica, Nela Pivac
Summary: This study aimed to evaluate cognitive decline and plasma BDNF concentration in veterans with combat-related PTSD. The results showed that veterans with PTSD had decreased plasma BDNF concentration and worse cognitive performance. Similar plasma BDNF reduction and cognitive decline were also found in subjects with mild cognitive impairment.
PSYCHIATRY RESEARCH
(2022)
Article
Chemistry, Physical
Dashuai Li, Jiaxin Lu, Changhua Wang, Yanmei Xing, Shuang Liang, Rui Wang, Xintong Zhang, Yichun Liu
Summary: High concentration VOCs pose a serious threat, and single technologies for their removal are usually limited by low efficiency and mineralization rate. This study developed a coupled photo-plasma catalytic technology that achieved superior degradation and mineralization of VOCs compared to traditional methods.
APPLIED CATALYSIS A-GENERAL
(2022)
Article
Infectious Diseases
Juergen Prattes, Joost Wauters, Daniele Roberto Giacobbe, Jon Salmanton-Garcia, Johan Maertens, Marc Bourgeois, Marijke Reynders, Lynn Rutsaert, Niels Van Regenmortel, Piet Lormans, Simon Feys, Alexander Christian Reisinger, Oliver A. Cornely, Tobias Lahmer, Maricela Valerio, Laurence Delhaes, Kauser Jabeen, Joerg Steinmann, Mathilde Chamula, Matteo Bassetti, Stefan Hatzl, Riina Rautemaa-Richardson, Philipp Koehler, Katrien Lagrou, Martin Hoenigl
Summary: Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a common complication among critically ill COVID-19 patients in ICU. It is more prevalent in older patients, those receiving invasive ventilation, and those receiving tocilizumab treatment. CAPA is an independent predictor of ICU mortality.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Health Policy & Services
Martin Hoenigl, Megan Lo, Christopher J. Coyne, Gabriel A. Wagner, Jill Blumenthal, Kushagra Mathur, Lucy E. Horton, Thomas C. S. Martin, Gary M. Vilke, Susan J. Little
Summary: The objective of this study was to determine the hospital costs and revenue of universal opt-out HIV emergency department (ED) screening. The study found that implementing universal screening resulted in a net profit for the hospital.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Infectious Diseases
Rosanne Sprute, Eva Van Braeckel, Holger Flick, Martin Hoenigl, Chris Kosmidis, Ritesh Agarwal, Jesper R. Davidsen, Christian B. Laursen, Oliver A. Cornely, Danila Seidel
Summary: This study aims to develop a scoring tool to quantify guideline adherence in the clinical management of CPA. A total of 27 recommendations were collected and weighed based on their strength and level of evidence. The EQUAL CPA Score is designed to be a comprehensive tool for measuring guideline adherence.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Jean-Pierre Gangneux, Martin Hoenigl, Nicolas Papon
Summary: By unraveling the mechanistic link between predisposing conditions and deadly infections by Aspergillus fumigatus (Af) in ICU patients, Sarden et al. have discovered a shared B1a lymphocyte-natural antibody-neutrophil defense pathway to Af, bringing new perspectives in diagnostics and therapeutics.
TRENDS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Jon Salmanton-Garcia, Wing-Yan Au, Martin Hoenigl, Louis Yi Ann Chai, Hamid Badali, Ariful Basher, Ronja A. Brockhoff, Sharon C. -A. Chen, Ariya Chindamporn, Anuradha Chowdhary, Christopher H. Heath, Kausar Jabeen, Jaehyeon Lee, Madonna Matar, Saad Jaber Taj-Aldeen, Ban Hock Tan, Kenji Uno, Retno Wahyuningsih, Liping Zhu, Arunaloke Chakrabarti, Oliver A. Cornely
Summary: Invasive fungal infections pose a significant threat to patients in Asia/Pacific with malignancies, uncontrolled diabetes mellitus, undiagnosed/untreated HIV/AIDS. Adequate access to diagnostic tools and antifungals is essential for IFI management and patient survival.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Infectious Diseases
Jannik Stemler, Sibylle C. Mellinghoff, Yascha Khodamoradi, Rosanne Sprute, Annika Y. Classen, Sonja E. Zapke, Martin Hoenigl, Robert Krause, Martin Schmidt-Hieber, Werner J. Heinz, Michael Klein, Philipp Koehler, Blasius Liss, Michael Koldehoff, Christoph Buhl, Olaf Penack, Georg Maschmeyer, Enrico Schalk, Cornelia Lass-Floerl, Meinolf Karthaus, Markus Ruhnke, Oliver A. Cornely, Daniel Teschner
Summary: Patients with haematological malignancies are at high risk of invasive fungal disease. The German Society of Haematology and Medical Oncology has updated their antifungal prophylaxis recommendations, recommending continued antifungal prophylaxis for patients with long-lasting neutropenia and posaconazole as the drug of choice. There is insufficient data to give general recommendations for antifungal prophylaxis in patients receiving novel treatments for HM, such as CAR-T-cell therapy or novel targeted therapies for AML.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Martin Hoenigl, Matthias Egger, Jessica Price, Robert Krause, Juergen Prattes, P. Lewis White
Summary: Timely diagnosis remains an unmet need in non-neutropenic patients at risk for aspergillosis, including those with COVID-19-associated pulmonary aspergillosis (CAPA). Currently available mycological tests show limited sensitivity when testing blood specimens. Metagenomic next-generation sequencing (mNGS) to detect microbial cell-free DNA (mcfDNA) in plasma might overcome some of the limitations of conventional diagnostics.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Infectious Diseases
Martin Hoenigl, Jon Salmanton-Garcia, Matthias Egger, Jean-Pierre Gangneux, Tihana Bicanic, Sevtap Arikan-Akdagli, Ana Alastruey-Izquierdo, Nikolai Klimko, Aleksandra Barac, Volkan Ozenci, Eelco F. J. Meijer, Nina Khanna, Matteo Bassetti, Riina Rautemaa-Richardson, Katrien Lagrou, Kai -Manuel Adam, Emin Halis Akalin, Murat Akova, Valentina Arsic Arsenijevic, Avinash Aujayeb, Ola Blennow, Stephane Bretagne, Francois Danion, Blandine Denis, Nick Alexander de Jonge, Guillaume Desoubeaux, Lubos Drgona, Nurettin Erben, Andrea Gori, Julio Garcia Rodriguez, Carolina Garcia-Vidal, Daniele Roberto Giacobbe, Anna L. Goodman, Petr Hamal, Helena Hammarstrom, Cristina Toscano, Fanny Lanternier, Cornelia Lass-Floerl, Deborah E. A. Lockhart, Thomas Longval, Laura Loughlin, Tadeja Matos, Malgorzata Mikulska, Manjusha Narayanan, Sonia Martin-Perez, Juergen Prattes, Benedict Rogers, Laman Rahimli, Maite Ruiz, Emmanuel Roilides, Michael Samarkos, Ulrike Scharmann, Uluhan Sili, Oguz Resat Sipahi, Alena Sivakova, Joerg Steinmann, Janina Trauth, Ozge Turhan, Jens Van Praet, Antonio Vena, P. Lewis White, Birgit Willinger, Anna Maria Tortorano, Maiken C. Arendrup, Philipp Koehler, Oliver A. Cornely
Summary: The European Confederation of Medical Mycology (ECMM) collected data on candidaemia patients in Europe to assess the association between adherence to guideline recommendations and outcomes. The study found that following the recommendations can improve the survival rate of patients.
LANCET INFECTIOUS DISEASES
(2023)
Review
Mycology
Johannes Boyer, Simon Feys, Isabella Zsifkovits, Martin Hoenigl, Matthias Egger
Summary: Despite improvements in treatment and diagnostics, invasive aspergillosis (IA) remains a devastating fungal disease with increasing cases around the world. The emergence of azole-resistant strains poses a new challenge for therapy. New drugs like olorofim, fosmanogepix, ibrexafungerp, opelconazole, and rezafungin are in late-stage development and offer potential new treatment options. Immunotherapy is also being explored as an additional therapy for IA. This review discusses current treatment strategies, potential new pharmaceutical options, and ongoing research in immunotherapy.
Review
Infectious Diseases
Matthias Egger, Romuald Bellmann, Robert Krause, Johannes Boyer, Daniela Jaksic, Martin Hoenigl
Summary: Invasive mold diseases require careful selection, dosing, and monitoring of antifungal drugs. Failure of initial antifungal therapy may necessitate treatment adaption, such as switching drug class or adding another drug for combination therapy. Currently, options for antifungal drug classes are limited, but novel antifungals with innovative mechanisms of action show promising results. These may expand options for salvage therapy in the future. This article outlines current recommendations for salvage therapy and future treatment options for invasive aspergillosis and mucormycosis.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Matthew E. Mead, Patricia Alves L. de Castro, Jacob L. Steenwyk, Jean-Pierre Gangneux, Martin Hoenigl, Juergen Prattes, Riina Rautemaa-Richardson, Helene B. Guegan, Caroline B. Moore, Cornelia Lass-Floerl, Florian Reizine, Clara Valero, Norman J. Van Rhijn, Michael J. Bromley, Antonis H. Rokas, Gustavo H. Goldman, Sara Gago, ECMM CAPA Study Grp
Summary: Secondary infections caused by Aspergillus fumigatus are a major cause of death in severe COVID-19 patients. Genomic analysis of 11 A. fumigatus isolates from CAPA patients in Europe revealed that CAPA isolates do not cluster based on geographic origin. Phenotypically, CAPA isolates are more similar to the A1160 reference strain, but differ from the Af293 strain in infection-relevant stresses. Further research is needed to understand the molecular epidemiology of CAPA and identify genetic factors contributing to copathogenicity and antifungal resistance in COVID-19 patients.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Stefan Hatzl, Lisa Kriegl, Florian Posch, Gernot Schilcher, Philipp Eller, Alexander Reisinger, Yvonne Grinschgl, Tina Muhr, Andreas Meinitzer, Martin Hoenigl, Robert Krause
Summary: Increasing the first loading dose of isavuconazole in critically ill patients with ECMO can result in higher plasma concentrations during the initial 24 hours of treatment. However, regardless of the loading dose regimen, all patient groups reached similar plasma concentrations in the subsequent treatment period.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Mycology
Martin Hoenigl, Jeffrey D. Jenks, Matthias Egger, Marcio Nucci, George R. Thompson II
Summary: In this study, we reviewed published cases of invasive fusariosis of the central nervous system (CNS) and found a high mortality rate among patients, with the majority being severely immunocompromised. Most patients received monotherapy with amphotericin B, but some were treated with voriconazole monotherapy or combination therapy with amphotericin B plus voriconazole.
Review
Dermatology
Zia Hashim, Alok Nath, Ajmal Khan, Mansi Gupta, Anup Kumar, Riksoam Chatterjee, Radha Krishan Dhiman, Martin Hoenigl, Naresh Kumar Tripathy
Summary: COVID-19-associated pulmonary aspergillosis (CAPA) is a highly lethal fungal infection, and glucocorticoids (GC) may be the main cause. This study found that systemic GC treatment increases the risk of CAPA development, especially with high-dose GC or dexamethasone treatment.
Review
Infectious Diseases
Jon Salmanton-Garcia, Martin Hoenigl, Jean-Pierre Gangneux, Esther Segal, Ana Alastruey-Izquierdo, Sevtap Arikan Akdagli, Katrien Lagrou, Volkan oezenci, Antonio Vena, Oliver A. Cornely
Summary: The diagnostic capacity for invasive fungal infections in Europe is generally good, but there are limitations in access to certain diagnostic tools and antifungal drugs. These limitations need to be addressed to ensure optimal diagnosis and treatment for all patients.