Article
Endocrinology & Metabolism
Bing Liu, Wei Yi, Xiaoxiang Mao, Ling Yang, Caijun Rao
Summary: The study found that ECH1 expression was significantly increased in human NASH biopsy specimens and in methionine choline-deficient (MCD) diet-fed mice. Overexpression of ECH1 alleviated hepatic steatosis, inflammation, fibrogenesis, apoptosis, and oxidative stress in mice, while also reducing alanine aminotransferase and proinflammatory cytokine levels in serum and triglyceride levels in livers. ECH1 may act as a potential therapeutic target for NASH by inhibiting ferroptosis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Plant Sciences
Dongyeop Kim, Sang Wook Kim, Haykuhi Charchoghlyan, Hojeong Jeong, Gi Dong Han
Summary: Plant-derived compounds are useful for managing liver disease, and the combination of herbal extracts can alleviate alcohol-induced hepatic disorders by modulating the inflammatory response and lipid metabolism in the liver.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Qiuchi Chen, Wei Fang, Yanan Shen, Dan Xu, Qiang Chen, Kun Cui, Kangsen Mai, Qinghui Ai
Summary: This study found that the deficiency of Cideb alone does not trigger severe inflammation in the liver. However, under ER stress, the expression of Cideb is suppressed by Chop, which inhibits the transport of lipoproteins in the liver, leading to exacerbated hepatic steatosis, oxidative stress, and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Bluher, Ulf Smith
Summary: Hepatic cell senescence is a key factor in human NAFLD/NASH. BMP4 and Gremlin 1 are identified as novel therapeutic targets.
Article
Biochemistry & Molecular Biology
Likun Yan, Xiao Zhang, Jie Fu, Qiang Liu, Xiaohua Lei, Zhenyu Cao, Ju Zhang, Yaoli Shao, Qing Tong, Wei Qin, Xinxu Liu, Chun Liu, Zhiqiang Liu, Zhenghao Li, Jueliang Lu, Xundi Xu
Summary: The study demonstrates that TRPV3 is overexpressed in liver cirrhosis, and its inhibition reduces liver fibrosis significantly while its agonist exacerbates progression. Knocking down TRPV3 in HSCs affects DNA synthesis, cell proliferation, and apoptosis. Further research is needed to explore the potential of TRPV3 as a therapeutic target for liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Yajuan Bi, Xue Wang, Lifeng Han, Yiqing Tian, Tongwei Bo, Caiyu Li, Bowen Shi, Chunshan Gui, Youcai Zhang
Summary: This study systematically investigated the inhibitory effect of 200 natural products on OCT1 and identified benzoylpaeoniflorin as the most potent and selective OCT1 inhibitor. Benzoylpaeoniflorin prevented lipid accumulation in hepatocytes and down-regulated lipogenic genes. These findings provide valuable insights into natural product-drug interactions involving OCT1 and offer potential for treating fatty liver diseases.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Nutrition & Dietetics
Wenya Zheng, Ziyu Song, Sha Li, Minmin Hu, Horia Shaukat, Hong Qin
Summary: The study demonstrated that sesamol (SEM) has inhibitory effects on oxidative stress induced by chronic high-fat diet (HFD) in the liver, reversing inflammation and enhancing antioxidant defenses through the Nrf2 pathway, ultimately protecting liver health.
Review
Oncology
Taojian Tu, Mario M. Alba, Aditi A. Datta, Handan Hong, Brittney Hua, Yunyi Jia, Jared Khan, Phillip Nguyen, Xiatoeng Niu, Pranav Pammidimukkala, Ielyzaveta Slarve, Qi Tang, Chenxi Xu, Yiren Zhou, Bangyan L. Stiles
Summary: Obesity is independently associated with an increased risk of carcinogenesis, particularly liver cancer. Liver lipid dysfunction and inflammation, as well as the involvement of liver macrophages, play crucial roles in driving the progression of liver cancer. Specific inflammatory mediators and molecular signals related to lipid metabolism are also involved in the activation and reprogramming of liver macrophages, contributing to the development of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Lingyan Ma, Yinhua Ni, Luting Hu, Yufeng Zhao, Liujie Zheng, Song Yang, Liyang Ni, Zhengwei Fu
Summary: Spermidine administration can reduce fat mass and plasma lipid profile in HFD-induced obese mice, improve hepatic steatosis, reduce adipose tissue inflammation, and enhance gut barrier function. Additionally, spermidine treatment also enhances thermogenic gene expression in brown adipose tissue.
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Nutrition & Dietetics
Nevenka Juretic, Ruth Sepulveda, Amanda D'Espessailles, Daniela B. Vera, Cynthia Cadagan, Manuel de Miguel, Daniel Gonzalez-Manan, Gladys Tapia
Summary: The dietary supplementation of an alpha-and gamma-tocopherol mixture attenuated adipocyte enlargement, hepatic steatosis, and metabolic inflammation induced by a high-fat diet in mice, possibly through PPAR-alpha/NF-kappa B modulation.
Article
Endocrinology & Metabolism
Eveline Bruinstroop, Jin Zhou, Madhulika Tripathi, Winifred W. Yau, Anita Boelen, Brijesh Kumar Singh, Paul M. Yen
Summary: The study found that in the early stages of nonalcoholic fatty liver disease, Dio1 gene expression and activity increased, which was associated with an increased T(3)/T-4 ratio. The results suggest that Dio1 regulates hepatic triglyceride content during hepatosteatosis and early nonalcoholic steatohepatitis.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Miaomiao Wu, Fan Yin, Xiaoli Wei, Ruixue Ren, Chongqing Chen, Menghua Liu, Ruyu Wang, Liu Yang, Ruiqian Xie, Shanyue Jiang, Ziming Wang, Rui Liu, Wentao Xu, Xuefu Wang, Jing Li, Hua Wang
Summary: Alcohol-associated liver disease (ALD) is a global health problem with no effective pharmacological treatments. This study reveals the role of CREG1 protein in the pathogenesis of ALD and suggests CREG1 as a potential therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
LiQing Jiang, LiYun Zhang, JiaChang Yang, Heng Shi, HanZhao Zhu, MengEn Zhai, LinHe Lu, XiaoWu Wang, Xia Yun Li, ShiQiang Yu, JinCheng Liu, WeiXun Duan
Summary: This study confirmed that 1-deoxynojirimycin (DNJ) can alleviate sepsis-induced myocardial injury by mediating oxidative stress, apoptosis, and inflammation in cardiomyocytes via the JAK2/STAT6 signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Nadine Gehrke, Lea J. Hofmann, Beate K. Straub, Frank Ruehle, Ari Waisman, Peter R. Galle, Joern M. Schattenberg
Summary: This study investigates the contribution of hepatic interleukin-1 receptor type 1 (IL-1R1) signaling to insulin sensitivity in nonalcoholic fatty liver disease. The results show that hepatocyte IL-1R1 knockout mice maintain higher insulin sensitivity despite a high-fat, high-carbohydrate diet, with less hepatic inflammation and stable IL-1R1 signaling compared to wild-type mice.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Environmental
Mari Ochiai, Nozomi Kurihara, Masashi Hirano, Akifumi Nakata, Hisato Iwata
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Biology
Yohei Fujishima, Akifumi Nakata, Risa Ujiie, Kosuke Kasai, Kentaro Ariyoshi, Valerie Swee Ting Goh, Kojun Suzuki, Hirofumi Tazoe, Masatoshi Yamada, Mitsuaki A. Yoshida, Tomisato Miura
Summary: This study evaluated the radiation effects on large Japanese field mice in contaminated areas of Fukushima through chromosome aberration analysis. The results showed that there were no radiation-specific chromosome aberrations observed in the mice, indicating that chronic low dose-rate radiation did not cause significant genetic damage in the studied population.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Kentaro Ariyoshi, Tomisato Miura, Kosuke Kasai, Valerie Swee Ting Goh, Yohei Fujishima, Akifumi Nakata, Atsushi Takahashi, Yoshinaka Shimizu, Hisashi Shinoda, Hideaki Yamashiro, Colin Seymour, Carmel Mothersill, Mitsuaki A. Yoshida
Summary: This study investigates the environmental radiation effects on wild animals after the Fukushima nuclear accident. The results suggest that high radiation doses can reduce the number of hematopoietic progenitor cells, possibly eliminating genomically unstable cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Valerie Swee Ting Goh, Ryo Nakayama, William F. Blakely, Yu Abe, Christelle En Lin Chua, Zi Huai Chew, Akifumi Nakata, Yohei Fujishima, Mitsuaki A. Yoshida, Kosuke Kasai, Kentaro Ariyoshi, Tomisato Miura
Summary: This study proposed an alternative CBMN harvest protocol for laboratories interested in culturing PBMCs and storing fixed cells, which yielded a high number of scorable BN cells for routine biodosimetry. The protocol was validated in DAPI, acridine orange and Giemsa stain, and in three other laboratories, showing promising results for CBMN analysis in isolated PBMC cultures.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biology
Kentaro Ariyoshi, Yota Hiroyama, Naoya Fujiwara, Tomisato Miura, Kosuke Kasai, Akifumi Nakata, Yohei Fujishima, Valerie Swee Ting Goh, Mitsuaki A. Yoshida
Summary: Alopecia is common after high-dose radiation exposure, but in neonatal mice, substances secreted from cheek tissues may prevent hair follicle loss. Exosome-like vesicles (ELV) from cheek skin tissues showed radiation protective effects on fibroblast cell lines, suggesting they could prevent hair follicle loss after radiation.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Kazuki Komatsu, Tsugumi Iwasaki, Kosuke Murata, Hideaki Yamashiro, Valerie Swee Ting Goh, Ryo Nakayama, Yohei Fujishima, Takumi Ono, Yasushi Kino, Yoshinaka Simizu, Atsushi Takahashi, Hisashi Shinoda, Kentaro Ariyoshi, Kosuke Kasai, Masatoshi Suzuki, Maria Grazia Palmerini, Manuel Belli, Guido Macchiarelli, Toshitaka Oka, Manabu Fukumoto, Mitsuaki A. Yoshida, Akifumi Nakata, Tomisato Miura
Summary: This study found that the chronic and low-dose-rate radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant accident had no adverse effects on the reproductive characteristics and functions of male raccoons.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Environmental Sciences
Yohei Fujishima, Yasushi Kino, Takumi Ono, Valerie Swee Ting Goh, Akifumi Nakata, Kentaro Ariyoshi, Kosuke Kasai, Tadashi Toyoda, Toru Akama, Hirofumi Tazoe, Masatoshi Yamada, Mitsuaki A. Yoshida, Tomisato Miura
Summary: The study found that free-roaming cats in Namie Town had higher levels of radioactive contamination, particularly in their testes and uterus and ovaries. There were variations in radioactivity levels among cats protected in the same location, and cesium levels in cats decreased annually.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Keisuke Sato, Ryosuke Tatsunami, Akifumi Nakata, Ken-ichi Komatsu, Shinji Harakawa, Takaki Nedachi, Kaoru Haketa, Hiroyuki Inagawa, Koji Wakame
Summary: The study showed that Kumaizasa leaf extract may regulate innate immunity by suppressing the expression of JNK and ERK, which are involved in inflammatory signal transduction.
ANTICANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Shinji Yuasa, Kaori Takanashi, Kenta Ukiana, Yoshihiro Mihara, Shinji Itoh
Summary: By investigating the 2-hydroxylation reaction of estradiol 17-sulfate by liver microsomes, CYP2C8 and 2C9 were identified as major enzymes involved in the production of 2-OH-ES. Compared to estradiol, estradiol sulfate was found to be a more likely substrate for 2-hydroxylation by both CYPs, suggesting a different role for 2-OH-ES in the body compared to 2-OH-E2.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Yoshihiro Mihara
Summary: This study introduces a self-vertical migration system for wastewater treatment adsorbents, successfully developing an alginate hydrogel composite with controlled specific gravity and buoyancy to achieve floating on the water surface after adsorption. This unique property showed faster removal of cesium ions compared to other adsorbents, demonstrating potential for treating large volumes of wastewater in environmental remediation.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2021)
Article
Biology
Akifumi Nakata, Keisuke Sato, Yohei Fujishima, Valerie Goh Swee Ting, Kanade Nakayama, Kentaro Ariyoshi, Chizuru Tsuruoka, Yi Shang, Daisuke Iizuka, Shizuko Kakinuma, Hideaki Yamashiro, Tomisato Miura
Summary: Translation: Although not only DNA damage, it has become clear that ionizing radiation can also induce epigenetic effects. Therefore, intergenerational effects from chronic low-dose exposures are possible concerns. It is crucial to elucidate the effects of radiation on germ cell maturation, fertilization, and embryonic development. Our study indicates that LDR may induce different DNA methylation patterns, and both low- and high-dose radiation before sexual maturity might affect gametogenesis and fertility.
Article
Biology
Kentaro Ariyoshi, Yohei Fujishima, Valerie Swee Ting Goh, Akifumi Nakata, Kosuke Kasai, Mitsuaki A. Yoshida, Tomisato Miura
Summary: Multiple epidemiological studies indicate that obesity is a significant risk factor for cancer development. The exact mechanisms underlying the relationship between obesity and cancer remain unknown, but obesity is thought to affect adipocytes' role in energy balance and disrupt adipokine, insulin, and sex steroid signaling. Recent research suggests that adipose tissue-derived exosome-like vesicles (ELVs) play a role in regulating metabolic homeostasis. In this study, adipose ELVs collected from obese and control mice were used to investigate their influence on radiation-induced cell death and genomic instability in mouse fibroblast cells.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Environmental Sciences
E. Kim, M. Narita, Y. Takashima, A. Nakata, K. Tani, O. Kurihara
Summary: This study found that irregularities on the skin surface can affect direct alpha measurements. Alpha-emitters applied to the skin surface would cause internal exposure in the case of injured skin.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Agriculture, Dairy & Animal Science
Kazuki Komatsu, Kohsuke Murata, Tsugumi Iwasaki, Syun Tokita, Shiina Yonekura, Satoshi Sugimura, Yohei Fujishima, Akifumi Nakata, Tomisato Miura, Hideaki Yamashiro
Summary: The study reveals that wild large Japanese field mice show dynamic changes in ovarian morphology and estradiol concentrations during the breeding season, indicating a correlation between seasonal follicle development and estradiol regulation. This species is considered as a potential alternative animal model for investigating seasonal reproductive changes and the impacts of environmental changes.
ANIMAL REPRODUCTION
(2021)
Article
Food Science & Technology
Koji Wakame, Muneaki Takahata, Yasuyoshi Miyake, Eri Yasuda, Yoshie Shimomiya, Akifumi Nakata, Kesiuke Sato, Yoshihiro Mihara, Akira Takaguri, Ken-ichi Komatu
FUNCTIONAL FOODS IN HEALTH AND DISEASE
(2020)