Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Review
Cell Biology
Manjari Kundu, Yoshimi Endo Greer, Jennifer L. Dine, Stanley Lipkowitz
Summary: This review discusses the signaling components and mechanisms of the TRAIL pathway, as well as the challenges and potential solutions for TRAIL/DR targeted therapy in TNBC clinical trials. The article also explores the pharmacokinetic and pharmacodynamic properties of DR agonists, patient selection through predictive biomarkers, and potential combination therapies. Additionally, recent findings on the impact of TRAIL treatment on the immune response and novel strategies to address these challenges are discussed.
Article
Biochemistry & Molecular Biology
Jia Liu, Tienian Zhu, Jiankun Liu, Yujie Cui, Shifang Yang, Ruijing Zhao
Summary: CPT in combination with Dox exhibits synergistic antitumor effects on triple-negative breast cancer through activation of the caspase cascade pathway, partly dependent on the upregulation of death receptor 4 and death receptor 5 induced by Dox.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Multidisciplinary Sciences
Carla Riera-Domingo, Eduarda Leite-Gomes, Iris Charatsidou, Peihua Zhao, Giovanna Carra, Federica Cappellesso, Larissa Mourao, Maxim De Schepper, Dana Liu, Jens Serneels, Mohamad-Gabriel Alameh, Vladimir V. Shuvaev, Tatjana Geukens, Edoardo Isnaldi, Hans Prenen, Drew Weissman, Vladimir R. Muzykantov, Stefaan Soenen, Christine Desmedt, Colinda L. G. J. Scheele, Anna Sablina, Mario Di Matteo, Rosa Martin-Perez, Massimiliano Mazzone
Summary: In the premetastatic niche, endothelial cells express tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5). TRAIL interacts with DR5 intracellularly to prevent its signaling and maintain a quiescent vascular phenotype. Absence of endothelial TRAIL leads to DR5 activation, causing endothelial cell death and compromising vascular integrity, thereby promoting cancer cell metastasis.
Review
Biochemistry & Molecular Biology
Subashani Maniam, Sandra Maniam
Summary: Targeted chemotherapy has become the forefront of cancer treatment, offering more effective treatment with reduced side effects through selective and specific features; Research targeting the compensatory mechanisms in tumor cells is progressing in order to overcome drug resistance; Promising small molecules that target autophagy and apoptosis are being developed for the difficult-to-treat TNBC, showing potential in preclinical data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Review
Biochemistry & Molecular Biology
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: AMG is a potent anti-cancer compound that inhibits every step of carcinogenesis, particularly against breast cancer. Combining natural medicine with nanotechnology offers hope and new treatment strategies.
Article
Cell Biology
Pengyun Li, Qiaohong Lin, Shiyang Sun, Ning Yang, Yu Xia, Shengjie Cao, Wenjuan Zhang, Qian Li, Haoxin Guo, Maoxiang Zhu, Yilong Wang, Zhibing Zheng, Song Li
Summary: This study identified the potential of dual targeting CB1 and ferroptosis as a promising therapeutic strategy for TNBC. By inhibiting CB1 and regulating lipid metabolism, the effectiveness of ferroptosis in TNBC cells can be enhanced, leading to tumor growth inhibition.
CELL DEATH & DISEASE
(2022)
Article
Food Science & Technology
Chih-Chuan Teng, Shui-Yi Tung, Ko-Chao Lee, Kam-Fai Lee, Wen-Shih Huang, Chien-Heng Shen, Meng-Chiao Hsieh, Cheng-Yi Huang, Jiunn-Ming Sheen, Hsing-Chun Kuo
Summary: The study revealed that CIL-102 significantly induces apoptosis in gastric cancer cells, along with increased production of ROS and intracellular levels of Ca2+. CIL-102 induces G2/M phase arrest in gastric cancer cells through the inactivation of CDK1/cyclin B1, involving various signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
K. M. A. Zinnah, Sang-Youel Park
Summary: The study demonstrated the mechanism behind the synergistic anticancer effect of amitriptyline and TRAIL, showing that amitriptyline increases TRAIL-induced apoptosis by upregulating death receptors DR4 and DR5. Inhibition of autophagy by amitriptyline was also shown to enhance DR4 and DR5 expression.
Review
Physiology
Laurel A. Grisanti
Summary: Cardiovascular disease is a leading cause of death globally. Cardiomyocyte death, which occurs in heart damage and stress, contributes to cardiac dysfunction and further damages the heart. Apoptosis, a regulated form of cell death, can occur through intrinsic or extrinsic pathways. The poorly characterized TNF-related ligand TRAIL and its receptors have been found to play a role in cardiac pathology. This article aims to provide an overview of the current understanding of TRAIL and its receptors in normal and pathological conditions in the heart.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manami Semba, Shinji Takamatsu, Sachiko Komazawa-Sakon, Eiji Miyoshi, Chiharu Nishiyama, Hiroyasu Nakano, Kenta Moriwaki
Summary: The study identified proscillaridin A as a promising agent that enhances the anti-cancer efficacy of TRAIL therapeutics, particularly in colon cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xinyu Zhou, Abel Soto-Gamez, Fleur Nijdam, Rita Setroikromo, Wim J. Quax
Summary: Combining transferrin and dihydroartemisinin enhances cell death in triple-negative breast cancer cells induced by TRAIL. This combination therapy triggers more cell death by increasing DR5 expression in sensitive cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan M. Gonzalez-Morena, Sara Escudeiro-Lopes, Jessica Mariane Ferreira-Mendes, Pavel Jakoube, Valentina Cutano, Judith Vinaixa-Forner, Petra Kralova Viziova, Andrea Hartmanova, Radislav Sedlacek, Susana Machado, Beata Malcekova, Zuzana Keckesova
Summary: Our study provides a deeper understanding of the mechanism of LACTB-mediated cancer cell death and demonstrates the dynamics of cellular responses under different genetic backgrounds.
Article
Cell Biology
Chuanbing Zang, Jan Eucker, Piet Habbel, Christian Neumann, Carsten-Oliver Schulz, Nikola Bangemann, Lutz Kissner, Hanno Riess, Hongyu Liu
Article
Engineering, Biomedical
Kristin Froehlich, David Hartzke, Franziska Schmidt, Jan Eucker, Aleksander Gurlo, Michael Sittinger, Jochen Ringe
ACTA BIOMATERIALIA
(2018)
Article
Oncology
Frederik Marme, Carlos Gomez-Roca, Kristina Graudenz, Funan Huang, John Lettieri, Carol Pena, Zuzana Jirakova Trnkova, Jan Eucker
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2018)
Article
Oncology
A. C. Regierer, R. Wolters, M. -P. Ufen, A. Weigel, I. Novopashenny, C. H. Koehne, H. Samonigg, J. Eucker, K. Possinger, M. B. Wischnewsky
ANNALS OF ONCOLOGY
(2014)
Article
Oncology
A. H. Meyer, A. Stroux, K. Lerch, J. Eucker, J. Eitle, K. Hohloch, M. Andrzejak, K. Possinger, B. Doerken, A. Pezzutto, C. W. Scholz
ANNALS OF ONCOLOGY
(2014)
Article
Hematology
Agnieszka Korfel, Thomas Elter, Eckhard Thiel, Matthias Haenel, Robert Moehle, Roland Schroers, Marcel Reiser, Martin Dreyling, Jan Eucker, Christian Scholz, Bernd Metzner, Alexander Roeth, Josef Birkmann, Uwe Schlegel, Peter Martus, Gerard Illerhaus, Lars Fischer
Article
Oncology
Chuanbing Zang, Jan Eucker, Hongyu Liu, Annekatrin Coordes, Minoo Lenarz, Kurt Possinger, Christian Wilfried Scholz
LEUKEMIA & LYMPHOMA
(2014)
Article
Multidisciplinary Sciences
Berit Maria Mueller, Elke Keil, Annika Lehmann, Klaus-Juergen Winzer, Christiane Richter-Ehrenstein, Judith Prinzler, Nikola Bangemann, Angela Reles, Sylvia Stadie, Winfried Schoenegg, Jan Eucker, Marcus Schmidt, Frank Lippek, Korinna Joehrens, Stefan Pahl, Bruno Valentin Sinn, Jan Budczies, Manfred Dietel, Carsten Denkert
Article
Cell & Tissue Engineering
Mujib Ullah, Jan Eucker, Michael Sittinger, Jochen Ringe
STEM CELL RESEARCH & THERAPY
(2013)
Article
Cardiac & Cardiovascular Systems
Markus S. Anker, Stephan von Haehling, Andrew J. S. Coats, Hanno Riess, Jan Eucker, Jan Porthun, Javed Butler, Mahir Karakas, Wilhelm Haverkamp, Ulf Landmesser, Stefan D. Anker
Summary: The study found a high prevalence of ventricular arrhythmias, particularly non-sustained ventricular tachycardia, in cancer patients. Non-sustained ventricular tachycardia and premature ventricular contractions were significant predictors of long-term mortality, independent of other mortality predictors.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Oncology
Bich Na Lee, Sora Jung, Maxim E. Darvin, Jan Eucker, Dagmar Kuehnhardt, Jalid Sehouli, Radoslav Chekerov, Alexa Patzelt, Harald Fuss, Ruo-Xi Yu, Juergen Lademann
ANTICANCER RESEARCH
(2016)
Article
Oncology
Piet Habbel, Annika Kurreck, Carsten-Oliver Schulz, Anne Constanze Regierer, David Kaul, Christian Wilfried Scholz, Christian Neumann, Kurt Possinger, Jan Eucker
ANTICANCER RESEARCH
(2015)
Article
Oncology
Jan Eucker, Chuanbing Zang, Yongan Zhou, Xinhua Li, Piet Habbel, Carsten-Oliver Schulz, Christian Scholz, Hongyu Liu
ANTICANCER RESEARCH
(2014)
Article
Oncology
Jan Eucker, Chuanbing Zang, Yongan Zhou, Xinhua Li, Piet Habbel, Christian Neumann, Christian Scholz, Hongyu Liu
ANTICANCER RESEARCH
(2014)