Journal
EXPERT REVIEW OF VACCINES
Volume 14, Issue 12, Pages 1623-1632Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2015.1091732
Keywords
adjuvant; Braun's lipoproteins; Clostridium difficile-associated diseases; cervical cancer; dengue virus; lipobox leader sequences; meningococcal group B; subunit vaccine; synthetic adjuvant PAMCSK4; Toll-like receptor agonist
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Funding
- Ministry of Science and Technology
- National Health Research Institutes, Taiwan
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Recombinant bacterial lipoproteins (RLP) with built-in immuno-stimulating properties for novel subunit vaccine development are reviewed. This platform technology offers the following advantages: easily converts antigens into highly immunogenic RLP using a fusion sequence containing lipobox; the lipid moiety of RLP is recognized as the danger signals in the immune system through the Toll-like receptor 2, so both innate and adaptive immune responses can be induced by RLP; serves as an efficient and cost-effective bioprocess for producing RLP in Escherichia coli and the feasibility and safety of this core platform technology has been successfully demonstrated in animal model studies including meningococcal group B subunit vaccine, dengue subunit vaccine, novel subunit vaccine against Clostridium difficile-associated diseases and HPV-based immunotherapeutic vaccines.
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