Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Dongqing Gao, Peipei Lu, Nan Zhang, Li Zhao, Jinhui Liu, Jia Yang, Jingmin Liu, Deli Zhao, Jialin Wang
Summary: This study examined the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese and aimed to provide more support for ESCC screenings. The results showed that the higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening and follow-up management should be strengthened for males and the elderly population.
Article
Immunology
Zhengqi Li, Lizhou Dou, Yueming Zhang, Shun He, Deli Zhao, Changqing Hao, Guohui Song, Wei Zhang, Yong Liu, Guiqi Wang
Summary: Important evidence suggests that the microbiota plays a key role in esophageal squamous cell carcinoma (ESCC). The study found that with disease progression, the alpha diversity of microbiota in saliva and cell brush samples decreased, and specific bacteria were identified as potential biomarkers. Further research could focus on the functional roles of these characteristic bacteria in ESCC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Qiu-Yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-Fei Xia, Yong Du, Run-Duan Lin, Li-Qiong Yang, Yu-Ting Sun, Da-Jun Yang, Jian Sun, Lin Zhang
Summary: High expression of AKAP8L is associated with poor prognosis of ESCC and can be considered an independent risk factor for ESCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Miao-Fen Chen, Ming-Shian Lu, Ching-Chuan Hsieh, Wen-Cheng Chen
Summary: Increasing evidence suggests that the microbiome can influence tumor growth and the tumor microenvironment in gastrointestinal cancers. Porphyromonas gingivalis, a periodontal pathogen, is associated with the development and progression of esophageal squamous cell carcinoma. Targeting P. gingivalis or blocking IL-6 signaling may be a potential strategy to prevent and treat EsoSCC associated with this oral bacterium.
Article
Surgery
Xiang-Lei Yuan, Wei Liu, Yan Liu, Xian-Hui Zeng, Yi Mou, Chun-Cheng Wu, Lian-Song Ye, Yu-Hang Zhang, Long He, Jing Feng, Wan-Hong Zhang, Jun Wang, Xin Chen, Yan-Xing Hu, Kai-Hua Zhang, Bing Hu
Summary: This study developed an artificial intelligence (AI) system to predict the subtypes of intrapapillary capillary loop (IPCL) in precancerous lesions and superficial esophageal squamous cell carcinoma (ESCC). The AI system showed better performance in predicting IPCL subtypes and invasion depth compared to endoscopists. It significantly improved the diagnostic ability of junior endoscopists and slightly elevated the performance of senior endoscopists. The proposed AI system has the potential to enhance the accuracy of IPCL classification in precancerous lesions and superficial ESCC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Ying-Hua Xie, Li-Qiang Ran, Zhi-Yong Wu, Chun Sun, Xiu-E Xu, Hai-Ying Zou, Wang-Kai Fang, Jian-Jun Xie
Summary: This study found that Integrin alpha 5 beta 1 is up-regulated in esophageal squamous cell carcinoma (ESCC) and is associated with prognosis. Knockdown of Integrin beta 1 and L1CAM can inhibit the proliferation, migration, and invasion of ESCC cells and reduce cisplatin resistance. These findings suggest that Integrin alpha 5 beta 1 and beta 1 play important roles in the development and chemo-resistance of ESCC.
Article
Surgery
Jing Wen, Geng Wang, Xuan Xie, Guangrong Lin, Hong Yang, Kongjia Luo, Qianwen Liu, Yihong Ling, Xiuying Xie, Peng Lin, Yuping Chen, Huizhong Zhang, Tiehua Rong, Jianhua Fu
Summary: This study aimed to identify prognostic biomarkers for lymph node-positive locoregional esophageal squamous cell carcinoma patients and established a reliable 4-miRNA based classifier for predicting overall survival. The classifier effectively stratified patients into high and low-risk groups, improving prognostic accuracy when combined with clinicopathological factors. Validation in internal testing and independent sets confirmed the prognostic utility of the classifier.
Review
Medicine, General & Internal
Tianjiao Wen, Wei Wang, Xinran Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and deadly cancer in developing countries, while the prognosis for esophageal precancerous conditions is better. However, the diagnosis and treatment of esophageal precancerous lesions face challenges. Biomarker research and drug development provide opportunities for treatment, and lifestyle changes are beneficial for prognosis. Multiple and sequential diagnoses and treatments are necessary for curing esophageal precancerous lesions and reducing the incidence and mortality of ESCC.
Article
Nutrition & Dietetics
Jingwen Dong, Min Gao, Lin Li, Xiaoyu Pan, Sheng-Yin Chen, Jun Li, Stephanie A. Smith-Warner, Xiaoguang Li, Hui Wang, Jiali Zheng
Summary: This study examined the relationship between the overall inflammatory potential of diets and esophageal precancerous lesions (EPLs) and esophageal squamous-cell cancer (ESCC). The study found a positive association between the inflammatory potential of diets and the odds of EPLs and ESCC. Consuming anti-inflammatory foods may be beneficial in preventing EPLs and ESCC.
Article
Medicine, Research & Experimental
Zong-Chao Liu, Wen-Hui Wu, Sha Huang, Zhong-Wu Li, Xue Li, Guang-Hou Shui, Sin Man Lam, Bo-Wen Li, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Summary: This study identified lipidomic signatures associated with the risk of gastric lesion progression and gastric cancer occurrence, with translational implications for gastric cancer prevention.
Article
Cell Biology
Wenhao Zhang, Junwen Luo, Zhaohua Xiao, Yifeng Zang, Xin Li, Yougjia Zhou, Jie Zhou, Zhongxian Tian, Jian Zhu, Xiaogang Zhao
Summary: Our study revealed a novel deubiquitinase, USP36, in regulating Hippo signaling in ESCC, which could be an encouraging drug target for Hippo-driven ESCC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Xue Li, Nai-Ren Zheng, Lin-Heng Wang, Zhong-Wu Li, Zong-Chao Liu, Hua Fan, Yi Wang, Jin Dai, Xiao-Tian Ni, Xin Wei, Ming-Wei Liu, Kai Li, Zhe-Xuan Li, Tong Zhou, Yang Zhang, Jing-Ying Zhang, Gaohaer Kadeerhan, Sha Huang, Wen-Hui Wu, Wei-Dong Liu, Xiu-Zhen Wu, Lan-Fu Zhang, Jian-Ming Xu, Markus Gerhard, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li, Jun Qin
Summary: By analyzing the proteomic landscape, we identified protein signatures associated with the progression of gastric lesions and the risk of early gastric cancer. These findings have important implications for identifying high-risk populations and early detection of gastric cancer.
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Meng Wang, Chun-Juan Wang, Hong-Qiu Gu, Xia Meng, Yong Jiang, Xin Yang, Jing Zhang, Yun-Yun Xiong, Xing-Quan Zhao, Li-Ping Liu, Yi-Long Wang, Yong-Jun Wang, Zi-Xiao Li
Summary: This study aims to explore the sex differences in stroke outcomes among Chinese patients. The results showed that female patients with acute ischemic stroke had higher rates of unfavorable functional outcomes at three months, especially among those aged 65 years and older. However, there were no significant sex differences in stroke recurrence, mortality, and unfavorable functional outcomes at other time points.
Article
Clinical Neurology
Meng Wang, Ying Han, Chun-Juan Wang, Tao Xue, Hong-Qiu Gu, Kai-Xuan Yang, Heng-Yi Liu, Man Cao, Xia Meng, Yong Jiang, Xin Yang, Jing Zhang, Yun-Yun Xiong, Xing-Quan Zhao, Li-Ping Liu, Yi-Long Wang, Tian-Jia Guan, Zi-Xiao Li, Yong-Jun Wang
Summary: Short-term exposure to PM2.5 is significantly associated with hospital admission for stroke in individuals with pre-existing medical histories, especially in older or female patients with AF. Preventive measures to reduce PM2.5 concentrations are particularly important in individuals with other medical co-morbidities.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Jie Xu, Zimo Chen, Meng Wang, Jinglin Mo, Jing Jing, Gulbahram Yalkun, Liye Dai, Xia Meng, Hao Li, Zixiao Li, Yongjun Wang
Summary: This study aimed to investigate the impact of low-density lipoprotein cholesterol (LDL-C) levels on the risk of intracranial hemorrhage in stroke patients. The results showed a significantly increased risk of intracranial hemorrhage in the subgroups with LDL-C levels of 1.40-1.79 mmol/L and <1.40 mmol/L.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Zixiao Li, Xinmiao Zhang, Lingling Ding, Jing Jing, Hong-Qiu Gu, Yong Jiang, Xia Meng, Chunying Du, Chunjuan Wang, Meng Wang, Man Xu, Yanxu Zhang, Meera Hu, Hao Li, Xiping Gong, Kehui Dong, Xingquan Zhao, Yilong Wang, Liping Liu, Ying Xian, Eric Peterson, Gregg C. Fonarow, Lee H. Schwamm, Yongjun Wang
Summary: This article describes the design and methods of a study investigating the impact of cerebrovascular disease AI-CDSS on the clinical outcomes and stroke care quality in China. The study randomly assigned 80 hospitals to either the AI-CDSS intervention group or the control group. The primary outcome is the occurrence of new vascular events at 3 months after stroke onset.
STROKE AND VASCULAR NEUROLOGY
(2023)
