A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair

Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway

(2017) Laura Y. Lu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB

(2017) Si-yong Gao et al.   PLoS One

Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade

(2016) Seth Levy et al.   BONE

Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

(2016) Kylie Anne Alexander et al.   IMMUNOLOGY AND CELL BIOLOGY

Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification

(2014) Liza J. Raggatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased fracture callus mineralization and strength in cathepsin K knockout mice

(2014) Michael A. Gentile et al.   BONE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Bone Density, Turnover, and Estimated Strength in Postmenopausal Women Treated With Odanacatib: A Randomized Trial

(2013) Kim Brixen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches

(2012) Céline Colnot et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cell replication in craniofacial periosteum: appositional vs. resorptive sites

(2011) Pannee Ochareon et al.   JOURNAL OF ANATOMY

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

(2011) Patricia J Masarachia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

(2011) Tara Cusick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

Denosumab and bisphosphonates: Different mechanisms of action and effects

(2010) Roland Baron et al.   BONE

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

(2010) Brenda L Pennypacker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Treatment with a Potent Cathepsin K Inhibitor Preserves Cortical and Trabecular Bone Mass in Ovariectomized Monkeys

(2009) G. B. Stroup et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoclasts secrete non-bone derived signals that induce bone formation

(2008) Morten A. Karsdal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The anabolic action of intermittent PTH in combination with cathepsin K Inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice

(2008) Hirotoshi Yamane et al.   BONE

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

(2008) T. Segovia-Silvestre et al.   HUMAN GENETICS

Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration

(2008) Céline Colnot   JOURNAL OF BONE AND MINERAL RESEARCH