Article
Radiology, Nuclear Medicine & Medical Imaging
Ece Dilege, Burak Celik, Okan Falay, Medine Boge, Serkan Sucu, Safa Toprak, Orhan Agcaoglu, Nilgun Kapucuoglu, Onur Demirkol
Summary: The purpose of this study was to evaluate the impact of SPECT/CT lymphoscintigraphy on targeted axillary dissection in node-positive breast cancer patients who had undergone neoadjuvant chemotherapy. The results showed that SPECT/CT lymphoscintigraphy can accurately localize clipped nodes and has significant implications for the treatment of breast cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Alejandra Garcia-Novoa, Benigno Acea-Nebril, Carlota Diaz Carballada, Alberto Bouzon Alejandro, Carmen Conde, Carmen Cereijo Garea, Jose Ramon Varela, Paz Santiago Freijanes, Silvia Antolin Novoa, Lourdes Calvo Martinez, Inma Diz, Sofia Rodriguez Martinez, Joaquin Mosquera Oses
Summary: The study analyzed the feasibility of wire/clip localization and sentinel lymph node biopsy for axillary staging in breast cancer patients, showing a high identification rate with combined marking techniques and enabling the avoidance of axillary lymph node dissection in a significant number of patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Adrienne B. Shannon, James Sun, Karenia Landa, Kirsten M. Baecher, Christian Wood, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Tsai, Mark B. Faries, Georgia M. Beasley, Vernon Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
Summary: The study revealed that in clinically localized Merkel cell carcinoma, males, patients over 75 years old, and those with lymphovascular invasion are more likely to have false negative SLNB results. Patients with false negative SLNB experienced shorter time to nodal recurrence and significantly worse survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Petronilla Staubach, Anton Scharl, Atanas Ignatov, Olaf Ortmann, Elisabeth C. Inwald, Thomas Hildebrandt, Michael Gerken, Monika Klinkhammer-Schalke, Sophia Scharl, Thomas Papathemelis
Summary: The study demonstrates that indocyanine green can be as effective as the radioisotope for SLNB in early breast cancer patients, even among those who have undergone NACT. This offers a potential alternative to overcome the limitations associated with radioactive Technetium(99m) colloid, such as limited availability, high costs, and radioactivity exposure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Minyan Chen, Shengmei Li, Meng Huang, Jingjing Guo, Xuan Huang, Wenhui Guo, Lili Chen, Yuxiang Lin, Lisa Jacobs, Chuan Wang, Fangmeng Fu
Summary: This study evaluated the feasibility and accuracy of using methylene-blue-dye alone for sentinel lymph node biopsy (SLNB) in node-positive breast cancer. The results showed that using a flowchart to optimize patient selection significantly reduces the false-negative rate (FNR).
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Calogero Cipolla, Antonio Galvano, Salvatore Vieni, Federica Saputo, Simona Lupo, Mario Latteri, Giuseppa Graceffa, Maria Rosaria Valerio
Summary: The study investigated the prognosis of patients with a single negative sentinel lymph node compared to those with two or more negative SLNs, finding no significant difference in median DFS except for a subset of patients treated with hormone therapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xin Yang, Yao Li, Xiao-tian Ren, Lei Fan, Bin Hua
Summary: This study evaluated the feasibility of using carbon nanoparticles (CNs) in combination with indocyanine green (ICG) and methylene blue (MB) as tracers for visualizing clip-marked metastatic nodes in targeted axillary dissection (TAD) after neoadjuvant therapy (NAT). The results showed that using CNs to locate clip-marked nodes and ICG/MB for SLN mapping is feasible, accurate, and safe.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Benigno Acea-Nebril, Alejandra Garcia-Novoa, Alberto Bouzon Alejandro, Carlota Diaz Carballada, Carmen Conde Iglesias
Summary: Axillary staging is crucial for breast cancer prognosis, with SLNB being the gold standard for early stages. However, there is controversy over axillary staging in cN+ patients who convert to cN0 after PST. Current validated methods include SLNB, TAD, and MARI, and we believe that biopsied and clipped lymph nodes can predict response to systemic treatment.
Article
Oncology
Brenna E. Swift, Melissa Tigert, Andra Nica, Al Covens, Danielle Vicus, Carlos Parra-Herran, Rachel Kupets, Raymond Osborne, Lilian T. Gien
Summary: This study assessed the accuracy of intraoperative pathologic examination in vulva cancer patients and evaluated patient outcomes. The results showed that intraoperative assessment of sentinel lymph nodes can accurately determine the need for lymphadenectomy and does not compromise patient outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Zhouzhou Bao, Binge Deng, Yuqing Zhang, Xiaowei Li, Ziyang Tan, Zhuowei Gu, Bobo Gu, Zhifeng Shao, Wen Di, Jian Ye
Summary: A new approach using Raman imaging and data processing has been developed for rapid and accurate diagnosis of metastatic SLN during surgery, achieving an accuracy of 87.5%, which may outperform the existing histopathological assessment method.
Article
Chemistry, Multidisciplinary
Binge Deng, Yaohui Wang, Yifan Wu, Wenjin Yin, Jinsong Lu, Jian Ye
Summary: The nontoxic Raman nanoparticle tracer GERTs allows for accurate identification of SLNs within 10 minutes in white New Zealand rabbit models, providing surgeons with over 4 hours to distinguish between SLNs and 2nd LNs. Additionally, GERTs have ultrahigh sensitivity, allowing for preoperative positioning information for minimally invasive surgery with no significant toxicity demonstrated in biosafety evaluations.
Article
Oncology
Sharonne Holtzman, Guillaume Stoffels, Matt Flint, Caitlin Carr, Monica Prasad-Hayes, Kristen Zeligs, Stephanie V. Blank
Summary: This study aimed to compare the progression free survival (PFS) and overall survival (OS) of patients with high-risk endometrial cancer (EC) who underwent sentinel lymph node (SLN) evaluation and pelvic +/- para-aortic lymphadenectomy (LND). The results showed no significant difference in the 3-year PFS between the SLN and LND groups, but the SLN group had a lower 3-year OS.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Enver Ozkurt, Erkan Yardimci, Mustafa Tukenmez, Yeliz Emine Ersoy, Ravza Yilmaz, Neslihan Cabioglu, Hasan Karanlik, Cemil Burak Kulle, Fatma Umit Malya, Semen Onder, Zuhal Gucin, Abdullah Igci, Vahit Ozmen, Ahmet Sait Dinccag, Mahmut Muslumanoglu
Article
Oncology
Enver Ozkurt, Takehiko Sakai, Stephanie M. Wong, Mustafa Tukenmez, Mehra Golshan
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Takehiko Sakai, Enver Ozkurt, Stephen DeSantis, Stephanie M. Wong, Laurel Rosenbaum, Hui Zheng, Mehra Golshan
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Editorial Material
Oncology
Enver Ozkurt, Mehra Golshan
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Enver Ozkurt, Stephanie Wong, Esther Rhei, Mehra Golshan, Jane Brock, Thanh U. Barbie
Summary: The study found that patients with T1 tubular carcinoma (TC) have low rates of axillary lymph node (LN) involvement, comparable to patients with ductal carcinoma in situ (DCIS) and lower than other types of ER-positive invasive ductal carcinoma (IDC) patients. There was no significant difference in 5-year and 10-year overall survival rates between TC patients with or without LN involvement. Therefore, tubular histology is independently associated with improved survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Neslihan Cabioglu, Hasan Karanlik, Mahmut Muslumanoglu, Guldeniz Karadeniz Cakmak, Didem Can Trablus, Mustafa Tukenmez, Yeliz E. Ersoy, Cihan Uras, Baha Zengel, Selman Emiroglu, Ayfer Kamali Polat, Levent Yeniay, Enver Ozkurt, Halil Kara, Kamuran Ibis, Adnan Aydiner, Vahit Ozmen, Abdullah Igci
Meeting Abstract
Oncology
Takehiko Sakai, Enver Ozkurt, Ricardo Pastorello, Stephanie Wong, Wei Wang, Bryan Iorgulescu, Susan Lester, Shinji Ohno, Mehra Golshan
ANNALS OF SURGICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Thanh Barbie, Jane Brock, Mehra Golshan, Enver Ozkurt, Esther Rhei
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Surgery
Enver Ozkurt, Umut Barbaros, Nihat Aksakal, Selim Dogan, Alp Bozbora
TURKISH JOURNAL OF SURGERY
(2020)
Article
Oncology
Zeliha Turkyilmaz, Tahacan Aydin, Ravza Yilmaz, Semen Onder, Enver Ozkurt, Mustafa Tukenmez, Mahmut Muslumanoglu, Gulden Acunas, Abdullah Igci, Vahit Ozmen, Ahmet Dincag, Neslihan Cabioglu
EUROPEAN JOURNAL OF BREAST HEALTH
(2019)
Meeting Abstract
Oncology
Enver Ozkurt, Takehiko Sakai, Camden Bay, Stephanie Wong, Mehra Golshan
ANNALS OF SURGICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Neslihan Cabioglu, Abdullah Igci, Hasan Karanlik, Mahmut Muslumanoglu, Guldeniz Karadeniz Cakmak, Selman Emirikci, Mustafa Tukenmez, Enver Ozkurt, Didem Can Trabulus, Ahmet Dinccag, Vahit Ozmen
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Enver Ozkurt, Mustafa Tukenmez, Ravza Yilmaz, Neslihan Cabioglu, Mahmut Muslumanoglu, Ahmet Said Dinccag, Abdullah Igci, Vahit Ozmen
EUROPEAN JOURNAL OF BREAST HEALTH
(2018)
Review
Oncology
Enver Ozkurt
EUROPEAN JOURNAL OF BREAST HEALTH
(2018)
Meeting Abstract
Oncology
Mustafa Tukenmez, Didem Can Trablus, Enver Ozkurt, Neslihan Cabioglu, Selim Dogan, Selman Emirikci, Abdullah Igci, Vahit Ozmen, Ahmet Dinccag, Yesim Eralp, Seden Kucucuk, Mahmut Muslumanoglu
ANNALS OF SURGICAL ONCOLOGY
(2018)