Article
Oncology
Alem Gebremariam, Mathewos Assefa, Adamu Addissie, Alemayehu Worku, Nebiyu Dereje, Aynalem Abreha, Wondemagegnehu Tigeneh, Lydia E. Pace, Eva Johanna Kantelhardt, Ahmedin Jemal
Summary: A significant number of breast cancer patients in Addis Ababa, Ethiopia experience delays in initiation of adjuvant chemotherapy, particularly among low-income women, despite a high level of treatment completion. This highlights the importance of public policy interventions to improve access to healthcare for low-income populations and enhance breast cancer care.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
C. Meyer, C. Bailleux, E. Chamorey, R. Schiappa, Y. Delpech, M. Dejode, Y. Fouche, J. Haudebourg, E. Barranger
Summary: This retrospective study identified factors delaying initiation of adjuvant chemotherapy after breast cancer surgery. The results showed that secondary procedure, inclusion in a therapeutic trial, and positive HER2 status significantly delayed the start of adjuvant chemotherapy.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Zaida Morante, Yomali Ferreyra, Joseph A. Pinto, Natalia Valdivieso, Carlos Castaneda, Tatiana Vidaurre, Guillermo Valencia, Patricia Rioja, Hugo Fuentes, Jose M. Cotrina, Silvia Neciosup, Henry L. Gomez
Summary: This study aimed to develop a prognostic model to estimate the effects of delayed adjuvant chemotherapy on risk subgroups of triple-negative breast cancer (TNBC). The results showed that delayed adjuvant chemotherapy increases the risk of distant recurrence-free survival (DRFS) in TNBC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Prashanth Ashok Kumar, Shweta Paulraj, Dongliang Wang, Danning Huang, Abirami Sivapiragasam
Summary: Studies on the timing of initiation of adjuvant chemotherapy (AC) in breast cancer patients have shown controversial results, but starting AC by 31-60 days after surgery appears to have the best survival outcomes, particularly in hormone positive/HER2 negative breast cancer. Delaying the start of AC after surgery can lead to poorer outcomes, emphasizing the importance of timely treatment initiation in breast cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yoshito Tomimaru, Hidetoshi Eguchi, Yoshimitsu Shimomura, Tetsuhisa Kitamura, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Shunsuke Onoe, Michiaki Unno, Daisuke Hashimoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Kenichiro Uemura, Yasutoshi Kimura, Sohei Satoi, Yoshifumi Takeyama, Comm of Clin Res, Japan Pancreas Soc
Summary: Based on the results of the Japan Adjuvant Study Group, S-1 adjuvant chemotherapy within 10 weeks after surgery has become the standard treatment for resected PDAC patients. A secondary analysis of a nationwide survey by the Japan Pancreas Society showed that early initiation of S-1 adjuvant chemotherapy may improve survival outcomes.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Ariana M. Chirban, Eduardo A. Vega, Onur C. Kutlu, Sebastian Mellado, Olga Kozyreva, Andris J. Zauls, Elena Panettieri, Oscar Salirrosas, Richard Freeman, Claudius Conrad
Summary: This retrospective study investigates the impact of chemotherapy and chemoradiotherapy on the survival of patients with pancreatic cancer after surgery, and finds that for patients with positive surgical margins who cannot avoid treatment delay, chemoradiotherapy may help mitigate the negative impact of delayed treatment.
SURGICAL ONCOLOGY-OXFORD
(2023)
Article
Surgery
Andrea M. Mesiti, Julianna Brouwer, Mehraneh D. Jafari, Yuqing Qiu, Lari Wenzel, Joseph Carmichael, Chelsea McKinney, Jason A. Zell, Alessio Pigazzi
Summary: This study aimed to assess the willingness of the general public to accept immediate adjuvant chemotherapy after surgery for colon cancer. The results showed that respondents with higher education were more likely to accept IAC for improved survival and quality of life, males were more likely to accept early termination of chemotherapy with possible side effects, and higher income respondents were more likely to accept early termination of chemotherapy without survival impact. Furthermore, 16% responded they would be very or extremely likely, and 52% respondents would be somewhat likely or likely to accept intraoperative chemotherapy, even if it may not be necessary.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Oncology
Zhenkun Fu, Zhoujun Lin, Mao Yang, Chenggang Li
Summary: Breast cancer is a common type of cancer, with surgery being the preferred treatment method. Various adjuvant therapies such as radiotherapy, chemotherapy, endocrine therapy, and targeted drug therapy can also be used.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaozhen Liu, Kewang Sun, Hongjian Yang, Lingli Xia, Kefeng Lu, Xuli Meng, Yongfeng Li
Summary: This study aimed to identify intraoperative and preoperative risk factors of severe lymphedema and develop a nomogram for estimating the risk of severe lymphedema within 3 years of surgery. It was found that age, positive lymph nodes, interpectoral (Rotter's) lymph nodes (IPNs) dissection, and educational level were independent risk factors for severe lymphedema. A nomogram was developed by integrating these factors and showed moderate performance in predicting the risk of severe lymphedema within 3 years of surgery.
Article
Oncology
Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, Riikka Huovinen, Arja Jukkola, Minna Tanner, Johan Ahlgren, Paivi Auvinen, Outi Lahdenpera, Kenneth Villman, Paul Nyandoto, Greger Nilsson, Paula Poikonen-Saksela, Vesa Kataja, Petri Bono, Jouni Junnila, Henrik Lindman
Summary: The study suggests that adding capecitabine to a chemotherapy regimen containing docetaxel, epirubicin, and cyclophosphamide can prolong the survival of patients with early breast cancer. Data shows that patients in the TX-CEX group had longer survival compared to those in the T-CEF group, especially for patients with estrogen receptor-negative and triple-negative cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
J. Lluch-Gomez, V. Nunez-Alvarez, C. de la Torre-Hita, M. Bernal-Gomez, A. Campini-Bermejo, E. Perdomo-Zaldivar, L. Rodriguez-Perez, J. Calvete-Candenas, M. J. Martinez-Bautista, E. Benitez-Rodriguez, J. M. Baena-Canada
Summary: Adjuvant trastuzumab has been the standard treatment for HER2+ breast cancer since 2006, and it reduces recurrence and mortality. This study analyzed the real-world health outcomes of patients treated with adjuvant trastuzumab in the past 15 years at one center in Spain. The results showed that the treatment improved overall and disease-free survival at 5 years, but also had cardiotoxicity. Factors such as age, hypertension, radiotherapy, neoadjuvant treatment, and cardiotoxicity should be considered to optimize outcomes in clinical practice.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Neelima Denduluri, Mark R. Somerfield, Mariana Chavez-MacGregor, Amy H. Comander, Zoneddy Dayao, Andrea Eisen, Rachel A. Freedman, Ragisha Gopalakrishnan, Stephanie L. Graff, Michael J. Hassett, Tari A. King, Gary H. Lyman, Gillian Rice Maupin, Raquel Nunes, Cheryl L. Perkins, Melinda L. Telli, Maureen E. Trudeau, Antonio C. Wolff, Sharon H. Giordano
Summary: The study recommends offering 14 cycles of adjuvant T-DM1 to patients with HER2-positive breast cancer with pathologic invasive residual disease after standard preoperative chemotherapy and HER2-targeted therapy, based on the results of the KATHERINE trial.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
Thomas L. Sutton, Ranish Patel, Shay Behrens, Issac Schwantes, Connor Fewel, Stuart K. Gardiner, Nathalie Johnson, Jennifer R. Garreau
Summary: In patients with hormone receptor-positive breast cancer, delaying endocrine therapy after neoadjuvant chemotherapy and adjuvant radiation is associated with worse recurrence-free survival.
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Jingyu Ge, Wenjia Zuo, Yiyu Chen, Zhiming Shao, Keda Yu
Summary: Triple-negative breast cancer is highly aggressive and often treated with chemotherapy, which can lead to increased toxicity. Dose-dense chemotherapy may enhance treatment efficacy, and different molecular subtypes may offer potential targets for more personalized treatment strategies.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Kirsten Y. Eom, G. J. van Londen, Jie Li, Bassam Dahman, Cathy Bradley, Lindsay M. Sabik
Summary: This study examined the changes in the initiation of adjuvant endocrine therapy (AET) among breast cancer patients in Massachusetts after the health reform in 2006. The findings show a significant relative increase in the likelihood of AET initiation among women in low-income areas compared to high-income areas, suggesting that expansions of health insurance coverage and improved access to care can help reduce socioeconomic disparities in breast cancer outcomes.
Article
Urology & Nephrology
Joan C. Delto, Aaron Fleishman, Peter Chang, Da David Jiang, Sara Hyde, Kyle McAnally, Catrina Crociani, Marcus Jamil, Hiten D. Patel, Jonathan Pavlinec, Jeffrey Budzyn, Adri Durant, Benjamin Eilender, Ashley O. Gordon, Mitchell M. Huang, Phillip M. Pierorazio, Jay D. Raman, Craig Rogers, Li-Ming Su, Andrew A. Wagner
Summary: The study evaluated the outcomes of perioperative aspirin use during robotic partial nephrectomy (RPN) in a multicenter setting. It found that the use of perioperative aspirin (81 mg) was reasonable and safe, but it was associated with a higher risk of blood transfusions and major complications.
JOURNAL OF UROLOGY
(2022)
Article
Surgery
Emily Wong, Aaron Fleishman, Amanda Brem, Daniel B. Jones, Christina C. Wee
Summary: One year after sleeve gastrectomy, one in five non-high-risk drinkers developed new high-risk alcohol intake. New high-risk drinkers had more disordered eating at baseline and reported greater improvement in eating behavior post-surgery.
Article
Oncology
Kenneth Softness, Sumedh Kaul, Aaron Fleishman, Jason Efstathiou, Joaquim Bellmunt, Simon P. Kim, Ruslan Korets, Peter Chang, Andrew Wagner, Aria F. Olumi, Boris Gershman
Summary: In this study, the comparative effectiveness of radical cystectomy (RC) and trimodality therapy (TMT) for muscle-invasive bladder cancer was evaluated using observational data. The results showed no statistically significant difference in overall survival (OS) between RC and TMT. However, when examining heterogeneity of treatment effects, RC appeared to be associated with improved OS only for patients with cT3 disease.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Surgery
Justin K. Yu, Jayson S. Marwaha, Chris J. Kennedy, Kortney A. Robinson, Aaron Fleishman, Brendin R. Beaulieu-Jones, Josh Bleicher, Lyen C. Huang, Peter Szolovits, Gabriel A. Brat
Summary: The study aimed to develop predictive models to determine whether a surgical patient's postdischarge opioid requirement will fall above or below common opioid prescribing guidelines. Patient characteristics reliably predicted postdischarge opioid consumption in relation to prescribing guidelines.
Article
Oncology
Maheetha Bharadwaj, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: Observational analyses emulating a completed randomized trial suggest that adjuvant chemotherapy following radical cystectomy may improve overall survival in locally advanced bladder cancer patients. The results were consistent across baseline patient and tumor characteristics.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Substance Abuse
Kortney A. Robinson, Jayson S. Marwaha, Chris J. Kennedy, Brendin R. Beaulieu-Jones, Aaron Fleishman, Justin K. Yu, Larry A. Nathanson, Gabriel A. Brat
Summary: Fixed opioid prescribing restrictions may affect pain control for some surgical patients. Patients undergoing orthopedic, spinal/neurosurgical, and complex abdominal procedures may require more opioids to adequately control post-surgical pain.
Article
Surgery
Melisa D. Granoff, Jaime A. Pardo, Anna Rose Johnson, Aaron Fleishman, Elizabeth Tillotson, Sarah Thomson, Bernard T. Lee, Dhruv Singhal
Summary: This study provides detailed information about the anatomy of three forearm lymphatic channels and their connections to the upper arm in adults without lymphatic disease, which is important for individuals performing procedures on the upper extremities.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Urology & Nephrology
Francisco Ramos, Ruslan Korets, Aaron Fleishman, Sumedh Kaul, Michael Johnson, Jesse L. Wei, Aria F. Olumi, Leo L. Tsai, Boris Gershman
Summary: This study compared the effectiveness of magnetic resonance imaging-ultrasound (MRI-U/S) fusion biopsy and in-bore MRI-targeted biopsy. The results showed no significant difference in cancer detection rates between the two biopsy techniques in per-patient analyses. However, MRI-IB biopsy had a higher clinically significant cancer detection rate when considering targeted biopsy cores only. This suggests that systematic cores should be obtained during MRI-U/S fusion biopsy.
Article
Oncology
Ernest Morton, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon P. Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: The study investigated the natural history and outcomes of patients with urothelial carcinoma of the bladder (UCB) and isolated lymph node involvement (cN0pN+) after surgical resection. The analysis of a large oncology database revealed that although overall survival (OS) for these patients is poor, a subset of patients demonstrates durable long-term survival with 5-and 7-year OS rates of 20% and 17%, respectively. Higher pT and pN stages are associated with increased all-cause mortality (ACM), while receipt of adjuvant chemotherapy is associated with reduced ACM.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Angela Estevez, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Joaquim Bellmunt, Aria F. Olumi, Heidi Rayala, Boris Gershman
Summary: This study aimed to evaluate the associations between socioeconomic characteristics and the management of non-muscle invasive bladder cancer (NMIBC). Through multivariable logistic regression, we found correlations between gender, insurance status, race, and education level with the management of high-risk NMIBC. These observations highlight important targets for future strategies to reduce healthcare disparities and provide more equitable bladder cancer treatment.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Surgery
Theofano Zoumpou, Aaron Fleishman, Daniel B. Jones, Christina C. Wee
Summary: This study found that a small percentage of sleeve gastrectomy (SG) patients (7%) expressed regret up to 6 years postoperatively, consistent with other research findings. Those who regretted the decision reported poorer quality of life, as well as lower weight loss and less improvement in physical health.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Melisa D. Granoff, Anna Rose Johnson, Kathy Shillue, Aaron Fleishman, Leo Tsai, Brett Carroll, Kevin Donohoe, Bernard T. Lee, Dhruv Singhal
Summary: This study describes the implementation of a debulking technique from Sweden in the United States and evaluates its outcomes in patients with chronic lymphedema. The results show that power assisted liposuction is an effective treatment option, reducing extremity volumes, infection rates, and reliance on outpatient therapy.
Article
Transplantation
James R. Rodrigue, Jessica Shenkel, Matthew Boger, Bohdan Pomahac, Aaron Fleishman
Summary: This study evaluated the impact of video messaging on the willingness of US military veterans to donate vascularized composite allograft (VCA) organs. The results showed that veterans exposed to VCA video messaging were more likely to express donation willingness, and blended messaging had a greater impact compared to informational messaging.
TRANSPLANTATION DIRECT
(2022)
Article
Surgery
Chris J. Kennedy, Jayson S. Marwaha, Brendin R. Beaulieu-Jones, P. Nina Scalise, Kortney A. Robinson, Brandon Booth, Aaron Fleishman, Larry A. Nathanson, Gabriel A. Brat
Summary: This study developed a method of efficiently collecting patient-reported pain outcomes through a text message-to-web survey system. By using patient factors recorded in the electronic health record for nonresponse adjustment, reliable estimates of post-discharge opioid consumption can be obtained.
SURGERY IN PRACTICE AND SCIENCE
(2022)
Article
Urology & Nephrology
Sijun Liu, Zongwei Wang, Xingbo Long, Aaron Fleishman, Xiangchun Huang, Qingguang Wu, Boris Gershman, Aria F. Olumi
Summary: Marital status and race were found to be prognostic factors for localized prostate cancer. Black or single patients had a higher risk of mortality, and single black patients had the worst prognosis. Married status had a prognostic advantage in all races, with whites and Asians having a lower risk compared to blacks.
CANADIAN JOURNAL OF UROLOGY
(2022)
