Article
Emergency Medicine
Xue Heng, Peng Cai, Zhiqiang Yuan, Yizhi Peng, Gaoxing Luo, Haisheng Li
Summary: Respiratory and circulatory dysfunction are common complications and leading causes of death among burn patients. This study aimed to comprehensively evaluate the efficacy and safety of extracorporeal membrane oxygenation (ECMO) in burn patients. The study found that ECMO can be an appropriate rescue therapy for burn patients despite relatively high mortality and complication rates.
Article
Critical Care Medicine
Chih-Han Huang, Chien-Sung Tsai, Yi-Ting Tsai, Chih-Yuan Lin, Hung-Yen Ke, Jia-Lin Chen, Yuan-Sheng Tzeng, Hung-Hui Liu, Chung-Yu Lai, Po-Shun Hsu
Summary: This study retrospectively analyzed 14 severely burned patients with concurrent inhalation injury and ARDS who were treated with ECLS. The results showed that ECLS could improve sustained hypoxemia in severely burned patients, but its efficacy in hemodynamic support was limited. Defining ECLS indications and selecting patients rigorously would contribute to better clinical outcomes.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Biochemistry & Molecular Biology
Hannah R. Hall, Cressida Mahung, Julia L. M. Dunn, Laurel M. Kartchner, Roland F. Seim, Bruce A. Cairns, Shannon M. Wallet, Robert Maile
Summary: The study aimed to investigate the role of mTOR in the immune response after burn and inhalation injury. The results showed that the murine B+I model had inhalation-specific immune phenotypes and suggested the involvement of mTOR in acute immune dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zhifang Niu, Ziling Ding, Yion Chan, Li Yan, Wenyu Zhang, Hongyu Wang, Jie Shi, Qi Lv, Shike Hou, Xiaoqin Guo, Haojun Fan
Summary: Smoke inhalation injuries refer to the damage to the respiratory tract and lung tissue caused by fire smoke entering the human lungs. This study analyzed the clinical characteristics of patients with smoke inhalation injuries and identified the risk factors affecting their prognosis. The findings showed that certain indicators were elevated with increasing severity of smoke inhalation injuries, while others decreased. Some indicators (such as white blood cells and lactic acid) could serve as markers for predicting the severity and mortality risk. These findings can contribute to the development of improved treatment plans for smoke inhalation injuries.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Medicine, General & Internal
Huankai Gong, Yao Chen, Meiling Chen, Jiankang Li, Hong Zhang, Shijiao Yan, Chuanzhu Lv
Summary: The introduction of Sepsis 3.0 guidelines in 2016 improved understanding of diagnosis and therapy for sepsis, while the recent Save Sepsis Campaign recommends personalized treatment strategies and nursing methods. However, sepsis patients still have a high mortality rate, with a significant percentage experiencing sepsis-related acute respiratory distress syndrome (ARDS) due to pulmonary epithelial and pulmonary endothelial injury.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Matthias Otto, Joerg Krebs, Peter Welker, Rene Holm, Manfred Thiel, Luciano Gattinoni, Michael Quintel, Charalambos Tsagogiorgas
Summary: Aerosol therapy for patients with ARDS has shown limited improvement in outcomes, potentially due to inability to reach dependent lung areas. Semi-fluorinated alkanes may address this issue by serving as a suitable carrier for pulmonary drug delivery. Experimental results demonstrate that F6H8 aerosol could effectively deliver drugs to dependent ARDS lung regions.
Article
Immunology
Rui Gong, Hong Luo, Gangyu Long, Jiqian Xu, Chaolin Huang, Xin Zhou, You Shang, Dingyu Zhang
Summary: In this study, we investigated sensitive non-invasive biomarkers associated with lung pathological changes in ARDS/ALI through integrative proteomic analysis. We identified common DEPs in serum and lung samples from direct ARDS mice and validated their clinical value in COVID-19-related ARDS cases. Six proteins with good clinical diagnostic and prognostic value were identified, providing potential targets for early detection and treatment of direct ARDS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gilles Parzibut, Monique Henket, Catherine Moermans, Ingrid Struman, Edouard Louis, Michel Malaise, Renaud Louis, Benoit Misset, Makon-Sebastien Njock, Julien Guiot
Summary: This study analyzed miRNA expression in plasma-derived exosomes of ARDS patients through small RNA sequencing, identifying differentially expressed miRNAs and validating their potential as diagnostic biomarkers in discriminating ARDS patients from healthy subjects.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Critical Care Medicine
Jehan Alladina, Sean D. Levy, Josalyn L. Cho, Kelsey L. Brait, Sowmya R. Rao, Alexander Camacho, Kathryn A. Hibbert, R. Scott Harris, Benjamin D. Medoff, James L. Januzzi, B. Taylor Thompson, Ednan K. Bajwa
Summary: The study suggests that elevations in sST2 concentrations in patients with AHRF may indicate ongoing lung injury and better predict patient outcomes. IL-6 concentrations did not correlate with outcomes. Therefore, using sST2 concentrations to guide ventilator management may be more accurate than traditional measures.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Xiaoyuan Yang, Victor Chatterjee, Ethan Zheng, Amanda Reynolds, Yonggang Ma, Nuria Villalba, Thanh Tran, Michelle Jung, David J. Smith, Mack H. Wu, Sarah Y. Yuan
Summary: This study comprehensively analyzed plasma extracellular vesicles (EVs) from burn patients and healthy subjects, revealing a significant increase in circulating EVs in burn patients, which correlated with injury severity and clinical outcomes. The burn-induced EVs were largely derived from leukocytes and endothelial cells, and contained unique cargo proteins. Functionally, burn EVs caused barrier dysfunction and disrupted cell-cell junction continuity.
Review
Biochemistry & Molecular Biology
Pradeesh Sivapalan, Barbara Bonnesen, Jens-Ulrik Jensen
Summary: ARDS is an acute inflammation of the lung caused by damage to the alveolar-capillary membrane, diagnosed using a combination of clinical and physiological variables. Recent research has identified biomarkers associated with ARDS pathophysiology, which may be useful for diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Sergey N. Avdeev, Natalia Trushenko, Svetlana Yu Chikina, Natalia A. Tsareva, Zamira M. Merzhoeva, Andrey Yaroshetskiy, Violetta Sopova, Margarita Sopova, Oleg A. Rosenberg, Ralph Theo Schermuly, Djuro Kosanovic
Summary: Inhaled surfactant therapy in patients with COVID-19-associated ARDS significantly improved oxygenation parameters, reduced the need for intensive care and invasive mechanical ventilation, and shortened the duration of non-invasive ventilation and hospital stay.
RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Huriye Bilge Tuncer, Merve Akin, Muge Cakirca, Ezgi Erkilic, Hanifi Furkan Yildiz, Ahmet Cinar Yasti
Summary: Interventions for burn management before transfer to a burn center are crucial in reducing mortality and morbidity. This study examined deficiencies in the implementation of burn patient care algorithms during pre-admission diagnosis and treatment. Among the enrolled patients referred to our burn center, inadequate resuscitation within the first 24 hours was found in 51.8% of cases. The study also identified high percentages of burned surface area before arrival and the need for improved adherence to guidelines for major burn cases. The findings highlight the importance of developing comprehensive burn patient care algorithms nationwide.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Critical Care Medicine
Pei Cui, Zhiping Tang, Qiu Zhan, Chunjiang Deng, Yanhua Lai, Fujun Zhu, Haiming Xin, Rongsheng Li, Anning Chen, Yalin Tong
Summary: This study found that tranilast has a protective effect on smoke inhalation mediated lung injury in rats. It also promotes the proliferation of certain lung cells and reduces the secretion of inflammatory cytokines and oxidative stress.
Article
Emergency Medicine
Kavita Krishnan, Alice Su, Garry Sigman, Cara Joyce, Megan A. Rech, Christina M. Long
Summary: The study aims to evaluate practices at Loyola University Medical Center emergency department in diagnosing and treating pediatric mild traumatic brain injuries (mTBIs), address inconsistencies, and determine future quality improvement measures.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Health Care Sciences & Services
Kantha Medepalli, Stefanie Purdon, Rebecca M. Bade, M. K. Glassberg, Ellen L. Burnham, Hayley B. Gershengorn
Summary: Women are underrepresented in leadership positions in academic internal medicine, and having women leaders is not independently associated with having more women trainees.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Critical Care Medicine
Jonathan K. Zakrajsek, Sung -Joon Min, P. Michael Ho, Tyree H. Kiser, Arun Kannappan, Peter D. Sottile, Richard R. Allen, Meghan D. Althoff, Paul M. Reynolds, Marc Moss, Ellen L. Burnham, Mark E. Mikkelsen, R. William Vandivier
Summary: This retrospective cohort study analyzed 13,714 patients with asthma exacerbations and respiratory failure, including 127 treated with ECMO and 13,587 without ECMO. The results showed that ECMO treatment was associated with lower mortality but higher hospital costs compared to standard care. These findings suggest that ECMO may be an important salvage therapy for refractory asthma exacerbations with respiratory failure.
Article
Obstetrics & Gynecology
Tanaka J. Dune, Arianna Griffin, Elizabeth Gunnar Hoffman, Cara Joyce, Susanne Taege, Linda Brubaker, Colleen M. Fitzgerald
Summary: This study investigated the relationship between external lumbar, hip, and/or pelvic girdle pain and internal vaginal pelvic floor myofascial pain, and found a correlation between the two. The high detection rate of internal vaginal pelvic floor myofascial pain highlights the opportunity to improve treatment planning, and suggests that vaginal pelvic floor muscle examination should be part of the assessment for women with lumbar, hip, and/or pelvic girdle pain.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Substance Abuse
Kevin Choy, Kiran U. Dyamenahalli, Shanawaj Khair, Kathryn L. Colborn, Arek J. Wiktor, Juan -Pablo Idrovo, Rachel H. McMahan, Ellen L. Burnham, Elizabeth J. Kovacs
Summary: Burn-injured patients with alcohol use disorder have higher morbidity and mortality rates compared to alcohol-abstaining individuals due to alcohol-induced dysregulation of the systemic inflammatory response, leading to worsened clinical outcomes. The study examined the effects of alcohol on inflammatory markers after burn injury and found that patients who misuse alcohol have aberrant inflammatory responses, which may result in immune dysregulation and worse clinical outcomes.
Article
Nursing
Sandi Tenfelde, Cara Joyce, Dina Tell, Lisa Masinter, Jena Wallander- Gemkow, Lindsey Garfield
Summary: The aim of this study was to develop a clinical decision support tool to identify FQHC patients with low postpartum care attendance. Predictive factors such as maternal age, parity, gestational age at first visit, and number of prenatal care visits were evaluated. The creation of a clinical decision support tool for identifying patients less likely to return for care was successful.
JOURNAL OF MIDWIFERY & WOMENS HEALTH
(2023)
Article
Clinical Neurology
Daniel M. Heiferman, Loren N. Riedy, Elhaum G. Rezaii, Mohammed Nuru, Dayna Sloane, Cara Joyce, Mary E. Moore, Rachyl M. Shanker, Kurt A. Grahnke, Giselle E. K. Malina, Caroline C. Szujewski, John P. Leonetti, Douglas E. Anderson
Summary: This study investigates the learning curve for acoustic neuroma resection and found that the steepest growth occurs in the first 400 surgeries. Furthermore, patient outcomes continued to improve even 30 years into practice, highlighting the importance of lifelong learning.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2023)
Article
Clinical Neurology
T. N. Mann, R. N. Dunn, A. J. Vlok, J. H. Davis
Summary: The aim of this study was to investigate the ten-year trends in the incidence of spine surgery in South Africa. The findings showed that spine surgery in South Africa has some similarities with developed countries but did not show a significant increase in utilization. This may be related to differences in the supply of spinal surgery.
EUROPEAN SPINE JOURNAL
(2023)
Article
Critical Care Medicine
Kevin E. Galicia, Callie M. Thompson, Aislinn E. Lewis, Cara J. Joyce, David M. Hill, Jeffery C. Schneider, Rachel M. Nyygard, David M. Harrington, James H. Holmes, Lauren T. Moffatt, Jeff W. Shupp, John C. Kubasiak
Summary: The BCQP is a platform that combines data from the National Burn Repository and the Burn Quality Improvement Program into a single registry. It aims to standardize data elements and definitions to align with other national trauma registries. With 103 participating burn centers and data from 375,000 patients, the BCQP is the largest registry of its kind. This whitepaper provides an overview of the BCQP, highlighting its unique features, strengths, limitations, and statistical considerations.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
D. Clark Files
Summary: An adaptive platform design was used to rapidly evaluate potential therapeutics for severe COVID-19. The study included hospitalized patients with severe COVID-19 and compared the outcomes of different treatment regimens. The results showed that none of the evaluated agents met the pre-specified efficacy criteria.
Article
Cardiac & Cardiovascular Systems
Joshua Sink, Cara Joyce, Max J. Liebo, David J. Wilber
Summary: Isolated cardiac sarcoid (iCS) and nonisolated cardiac sarcoid (nonisolated CS) have different clinical presentations but similar long-term outcomes, possibly due to diagnostic delays.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Respiratory System
Paul M. Reynolds, Majid Afshar, Garth C. Wright, P. Michael Ho, Tyree H. Kiser, Peter D. Sottile, Meghan D. Althoff, Marc Moss, Sarah E. Jolley, R. William Vandivier, Ellen L. Burnham
Summary: In patients with pneumonia requiring ICU admission, alcohol and stimulant misuse are associated with increased mortality, while other substance misuse does not have a significant impact on mortality.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Keaton S. S. Smetana, Alexander H. H. Flannery, Payal K. K. Gurnani, William J. J. Peppard, Megan A. A. Van Berkel Patel, Cara Joyce, Megan A. A. Rech
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
Article
Dermatology
Andrew Creadore, Priya Manjaly, Elizabeth Tkachenko, David G. Li, Benjamin Kaffenberger, Kanade Shinkai, Misha Rosenbach, Cara Joyce, Arash Mostaghimi
Summary: Dermatology consultation improves the accuracy and management of presumed cellulitis cases. However, in-person consultation is limited, and teledermatology could fill this gap. Augmented teledermatology may improve outcomes for patients.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anne Thorndyke, Cara Joyce, Manpreet Samra, Laura Cotiguala, Christine Trotter, Oswaldo Aguirre, W. James Chon, Rupinder Sodhi, Reynold I. Lopez-Soler
Summary: Cytomegalovirus (CMV) and BK Polyomavirus (BKPyV) are common opportunistic pathogens following kidney transplantation. This study evaluated 102 kidney transplant patients and found a high incidence of CMV and BKPyV infections, with a low rate of coinfection. The incidence of CMV infection was affected by the use of specific drugs, while BKPyV infection was associated with recipient's race and cPRA levels. Most infections occurred within the first six months post-transplant.