Review
Hematology
Zhumei Zhan, Wei Guo, Xin Wan, Ou Bai
Summary: With advancements in NHL therapeutics, long-term survival of NHL patients has increased. However, the concern for SPMs as a long-term complication for NHL survivors has grown. The factors leading to SPMs are multifactorial and include germline alterations, immune dysregulation, and external factors such as lifestyle and exposure to certain agents. Targeted therapies may reduce the incidence of t-MNs in indolent B-cell NHL.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Terry Boyle, Geffen Kleinstern, Paige M. Bracci, James R. Cerhan, Yolanda Benavente, Delphine Casabonne, Brian C-H Chiu, Thomas M. Habermann, Elizabeth A. Holly, Mark Liebow, Aaron Norman, Ora Paltiel, Dennis Robinson, Nathaniel Rothman, Rania Abu Seir, Susan L. Slager, Paul J. Villeneuve, Sophia S. Wang, Dennis D. Weisenburger, John J. Spinelli
Summary: This study, which pooled data from nine case-control studies, found that moderate-to-vigorous intensity physical activity can reduce the risk of non-Hodgkin lymphoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Yurou Chu, Yingyue Liu, Xiaosheng Fang, Yujie Jiang, Mei Ding, Xueling Ge, Dai Yuan, Kang Lu, Peipei Li, Ying Li, Hongzhi Xu, Juan Fan, Xiangxiang Zhou, Xin Wang
Summary: This study summarized the global burden, risk factors, and trends in the incidence and mortality of non-Hodgkin's lymphoma (NHL). The global annual number of new NHL cases is approximately 545,000, with 260,000 deaths. NHL incidence and mortality rates have been steadily increasing, particularly among women, older adults, obese populations, and HIV-infected individuals. Future efforts should focus on raising health awareness and implementing tailored cancer prevention strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
AnnaLynn M. Williams, Sedigheh Mirzaei Salehabadi, Mengqi Xing, Nicholas S. Phillips, Matthew J. Ehrhardt, Rebecca Howell, Yutaka Yasui, Kevin C. Oeffinger, Todd Gibson, Eric J. Chow, Wendy Leisenring, Deokumar Srivastava, Melissa M. Hudson, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull
Summary: Long-term survivors of childhood Hodgkin lymphoma (HL) face a high risk of neurocognitive and psychosocial impairment. Smoking and lack of exercise are associated with neurocognitive and psychosocial issues.
Article
Public, Environmental & Occupational Health
Elsie Touma, Leony Antoun, Souheil Hallit, Fadi Nasr, Marcel Massoud, Radwan El Othman, Georges Chahine
Summary: In Lebanon, lymphomas are mainly B-cell lymphomas, with diffuse large B-cell lymphoma being the most common subtype. High-grade tumors make up a significant proportion of patients, with 36.5% of patients presenting with extranodal disease at diagnosis.
Review
Oncology
Jing Yang, Limin Chai, Junting Jia, Liping Su, Zhiying Hao
Summary: This study aimed to explore the risk factors and incidence of interstitial pneumonitis (IP) in non-Hodgkin Lymphoma (NHL) patients. The study found that drug-related risk factors, including pegylated liposomes doxorubicin (PLD) replacement, rituximab (RTX) addition, and granulocyte colony stimulating factor (G-CSF) administration, were significantly associated with IP development. The study provides important insights for clinicians to detect and treat IP in NHL patients received CHOP-like chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Junjie Huang, Wing Sze Pang, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study evaluated the worldwide incidence, mortality, associated risk factors, and temporal trends of Hodgkin lymphoma. The findings showed an increasing incidence of Hodgkin lymphoma, especially among females, younger population, and subjects from Asian countries. However, the mortality rate was found to be higher in low-income countries.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
James Yarmolinsky, Christopher I. Amos, Rayjean J. Hung, Victor Moreno, Kimberley Burrows, Karl Smith-Byrne, Joshua R. Atkins, Paul Brennan, James D. McKay, Richard M. Martin, George Davey Smith
Summary: Deucravacitinib, a selective TYK2 inhibitor, is being reviewed for the treatment of psoriasis. However, there are concerns about the safety of TYK2 inhibition due to the increased risk of lung cancer and non-Hodgkin lymphoma associated with similar medications. Genetic analysis using a loss-of-function variant in TYK2 showed an increased risk of lung cancer and non-Hodgkin lymphoma with therapeutic TYK2 inhibition. These findings have important implications for the safety assessment of deucravacitinib and other TYK2 inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Lauren R. Teras, Kimberly A. Bertrand, Emily L. Deubler, Chun R. Chao, James V. Lacey, Alpa Patel, Bernard A. Rosner, Yu-Hsiang Shu, Ke Wang, Charlie Zhong, Sophia S. Wang, Brenda M. Birmann
Summary: In this study, the associations between body size and risk of non-Hodgkin lymphoma (NHL) were examined using data from six US-based cohorts. The results showed that adult height was broadly associated with NHL, particularly with B-cell NHLs among non-White participants. The strongest association was found between young adult BMI and risk of diffuse large B-cell lymphoma (DLBCL).
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Karine A. Al Feghali, Penny Fang, Maria Gule-Monroe, Sarah Milgrom, Joseph D. Khoury, Jillian R. Gunther, Tommy Sheu, Ranjit Nair, Sairah Ahmed, Raphael Steiner, Paolo Strati, Elizabeth J. Shpall, Yago L. Nieto, Chitra Hosing, Loretta J. Nastoupil, Jason R. Westin, Sattva S. Neelapu, Nathan Fowler, Christopher Flowers, Chelsea C. Pinnix, Bouthaina S. Dabaja
Summary: The distribution of baseline disease can impact the prognosis of patients with secondary CNS DLBCL, with those having localized disease potentially benefiting from stem cell transplantation post-Radiation Therapy. Receipt of SCT, response after RT, and presence of localized disease were associated with improved overall survival and CNS-disease-free survival.
LEUKEMIA & LYMPHOMA
(2021)
Article
Multidisciplinary Sciences
Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Yang Liu, Rongjia Zhang, Joseph McIntosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E. Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang
Summary: This study investigates the mechanisms driving resistance to treatment in mantle cell lymphoma (MCL) by analyzing the cellular and molecular heterogeneity within patients using single-cell sequencing. The researchers found temporal activation of cancer hallmark pathways and acquisition of 17q in refractory MCL, leading to upregulation of BIRC5/survivin expression. They demonstrate that targeting BIRC5 results in effective tumor inhibition in preclinical models and also identify changes in the tumor microenvironment in refractory MCL, including decreased CD8+ T cells and aberrant cell-to-cell communication networks.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Dai Chihara, Melissa C. Larson, Dennis P. Robinson, Carrie A. Thompson, Matthew J. Maurer, Carla Casulo, Priyanka Pophali, Brian K. Link, Thomas M. Habermann, Andrew L. Feldman, Christopher R. Flowers, James R. Cerhan, Lindsay M. Morton
Summary: The impact of obesity on lymphoma-specific survival varies among different subtypes of lymphoma, with obesity associated with shorter survival in follicular lymphoma (FL) patients but not in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients. Further research is needed to explore the effects of weight control in FL patients post-diagnosis.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Hua-Jay J. Cherng, Hubert H. Chuang, Raphael Steiner, Luis Fayad, Paolo Strati, Ranjit Nair, Fredrick Hagemeister, Loretta J. Nastoupil, Hun Ju Lee, Sattva S. Neelapu, Christopher R. Flowers, Felipe Samaniego, Maria Rodriguez, Homer A. Macapinlac, Lei Feng, Jason Westin
Summary: This study suggests that early PET/CT may predict treatment failure in patients with relapsed or refractory DLBCL, highlighting the potential benefits of early therapy changes for those who do not respond well to salvage chemotherapy. Further investigation into non-chemotherapy treatments based on early PET/CT findings could be valuable for future clinical trials.
LEUKEMIA & LYMPHOMA
(2022)
Letter
Oncology
Mario L. Marques-Piubelli, Luisa M. Solis, Edwin R. Parra, Luis Malpica Castillo, Sushanth Gouni, Ranjit Nair, Dai Chihara, Marina Konopleva, Ignacio I. Wistuba, Swaminathan P. Iyer, Francisco Vega, Paolo Strati
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Dai Chihara, Erich P. Huang, Shanda R. Finnigan, Lisa M. Cordes, Nebojsa Skorupan, Yoko Fukuda, Larry Rubinstein, S. Percy Ivy, James H. Doroshow, Loretta J. Nastoupil, Christopher R. Flowers, Naoko Takebe
Summary: In the past two decades, the development of cancer drugs has shifted from cytotoxic chemotherapy to targeted treatment. This study analyzed patient-level data from phase I trials sponsored by the National Cancer Institute Cancer Therapy Evaluation Program to assess the trend of toxicity and response rates for patients with hematologic malignancies over time. The study found that the overall response and complete response rates improved significantly, while the rate of toxicity-related death remained stable.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Critical Care Medicine
Joseph Allencherril, Paul Yong Kyu Lee, Khurrum Khan, Asad Loya, Annie Pally
Summary: The most prevalent causes of in-hospital cardiac arrest among general ward patients are hypoxia, acute coronary syndrome, hypovolemia, arrhythmias, infection, and heart failure. These etiologies differ from the traditional H's and T's of cardiac arrest.
Article
Oncology
Can Xie, Ruosha Li, Xuelin Huang, Dai Chihara, Christopher R. Flowers
Summary: The use of R-CHOP in the first line of treatment was associated with longer survival in older patients.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Letter
Hematology
Juan Pablo Alderuccio, Isildinha M. Reis, Jean L. Koff, Melissa C. Larson, Dai Chihara, Wei Zhao, Sara Haddadi, Thomas M. Habermann, Peter Martin, Jennifer R. Chapman, Christopher Strouse, Brad S. Kahl, Jonathon B. Cohen, Jonathan W. Friedberg, James R. Cerhan, Christopher R. Flowers, Izidore S. Lossos
Article
Hematology
Kelly S. Chien, Christine B. Peterson, Elliana Young, Dai Chihara, Elizabet E. Manasanch, Jeremy L. Ramdial, Philip A. Thompson
Summary: Patients with hematologic malignancies who have been vaccinated against COVID-19 have lower hospitalization rates compared to those who have not been vaccinated, but their rates of COVID-19-associated death are similar. Female, older patients, and individuals with higher comorbidity scores are at higher risk of death from COVID-19 infections. Vaccination is associated with a decreased risk of hospitalization but not with a decreased risk of death from COVID-19 infections. Protective strategies are needed in addition to vaccination for this vulnerable patient population.
Article
Hematology
Dai Chihara, Laura Liao, Joseph Tkacz, Anjali Franco, Benjamin Lewing, Karl M. Kilgore, Loretta J. Nastoupil, Lei Chen
Summary: This study analyzed the outcomes and costs of CAR T-cell therapy in 551 older patients (aged >= 65 years) with DLBCL. The results showed that CAR T-cell therapy was less used in older patients, especially those aged >= 75 years, and this age group had a lower rate of event-free survival. This highlights the need for more accessible, effective, and tolerable therapy in older patients.
Review
Hematology
Dai Chihara, Loretta J. Nastoupil, Christopher R. Flowers
Summary: Machine learning approaches have been used in the diagnosis and prediction of haematological malignancies. This article discusses the methods used to develop relevant algorithms and reviews research studies on the use of machine learning algorithms in the diagnosis and prognosis of lymphoma.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Paul Y. Lee, Juan Bello, Catherine Ye, Shruti Varadarajan, Afif Hossain, Saahil Jumkhawala, Abhishek Sharma, Joseph Allencherril
Summary: This study aimed to determine the safety and efficacy of protamine in reversing heparin during percutaneous coronary intervention (PCI). The analysis of 11 studies revealed that the use of protamine in patients treated with dual antiplatelet therapy (DAPT) can facilitate earlier sheath removal, reduce major bleeding complications, and shorten hospitalization duration without an increased risk of stent thrombosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Paul Y. Lee, Kyrollos Saad, Afif Hossain, Irene Lieu, Joseph Allencherril
Summary: This article reviews the initial evaluation of chest pain in the emergency department, focusing on coronary artery disease and acute coronary syndromes, using consensus statements from major cardiovascular disease organizations.
CURRENT CARDIOLOGY REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Paul Y. Lee, Hasan Garan, Elaine Y. Wan, Brian E. Scully, Angelo Biviano, Hirad Yarmohammadi
Summary: This study aims to review the arrhythmogenic effects of common viruses and emphasizes the need for further research in this area.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
