Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects

(2014) Borimas Hanboonkunupakarn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Delayed Parasite Clearance after Treatment with Dihydroartemisinin-Piperaquine in Plasmodium falciparum Malaria Patients in Central Vietnam

(2014) Kamala Thriemer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Throughput Ultrasensitive Molecular Techniques for Quantifying Low-Density Malaria Parasitemias

(2014) Mallika Imwong et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study

(2014) Steve M. Taylor et al.   JOURNAL OF INFECTIOUS DISEASES

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis

(2014) Ric N Price et al.   LANCET INFECTIOUS DISEASES

The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study

(2014) Jean-François Trape et al.   LANCET INFECTIOUS DISEASES

“…still waiting for chloroquine”: the challenge of communicating changes in first-line treatment policy for uncomplicated malaria in a remote Kenyan district

(2014) Vincent Okungu et al.   MALARIA JOURNAL

Novel approaches to risk stratification to support malaria elimination: an example from Cambodia

(2014) Jonathan Cox et al.   MALARIA JOURNAL

Primaquine: the risks and the benefits

(2014) Elizabeth A Ashley et al.   MALARIA JOURNAL

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing Coverage in Mass Drug Administration for Lymphatic Filariasis Elimination in an Urban Setting: a Study of Malindi Town, Kenya

(2014) Doris W. Njomo et al.   PLoS One

The genetics of resistant malaria

(2014) G. Vogel   SCIENCE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

(2014) Akhil B. Vaidya et al.   Nature Communications

Impact of Intermittent Screening and Treatment for Malaria among School Children in Kenya: A Cluster Randomised Trial

(2014) Katherine E. Halliday et al.   PLOS MEDICINE

THE IMPORTANCE OF MOSQUITO BEHAVIOURAL ADAPTATIONS TO MALARIA CONTROL IN AFRICA

(2013) Michelle L. Gatton et al.   EVOLUTION

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

(2013) Xiaofang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malaria

(2013) Nicholas J White et al.   LANCET

A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso

(2013) Alfred B Tiono et al.   MALARIA JOURNAL

Declining burden of malaria over two decades in a rural community of Muheza district, north-eastern Tanzania

(2013) Deus S Ishengoma et al.   MALARIA JOURNAL

Importation of chloroquine-resistant Plasmodium falciparum by Guatemalan peacekeepers returning from the Democratic Republic of the Congo

(2013) Patricia C Juliao et al.   MALARIA JOURNAL

Integrating child health services into malaria control services of village malaria workers in remote Cambodia: service utilization and knowledge of malaria management of caregivers

(2013) Aya Hasegawa et al.   MALARIA JOURNAL

Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China

(2013) Michelle S Hsiang et al.   MALARIA JOURNAL

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Antimalarial drug discovery – the path towards eradication

(2013) JEREMY N BURROWS et al.   PARASITOLOGY

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

(2013) J.-P. David et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Qinghaosu (artemisinin): Chemistry and pharmacology

(2012) Ying Li   ACTA PHARMACOLOGICA SINICA

Randomized, Double-Blind, Placebo-Controlled Trial of Monthly versus Bimonthly Dihydroartemisinin-Piperaquine Chemoprevention in Adults at High Risk of Malaria

(2012) Khin Maung Lwin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

(2012) Joerg J. Moehrle et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Effect of Primaquine on Gametocyte Development and Clearance in the Treatment of Uncomplicated Falciparum Malaria With Dihydroartemisinin-Piperaquine in South Sumatra, Western Indonesia: An Open-Label, Randomized, Controlled Trial

(2012) Inge Sutanto et al.   CLINICAL INFECTIOUS DISEASES

Impact of environment on mosquito response to pyrethroid insecticides: Facts, evidences and prospects

(2012) Theresia Estomih Nkya et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance

(2012) Toshihiro Mita et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Changes in malaria morbidity and mortality in Mpumalanga Province, South Africa (2001- 2009): a retrospective study

(2012) Lindokuhle Ngomane et al.   MALARIA JOURNAL

Scale-up of community-based malaria control can be achieved without degrading community health workers' service quality: the Village Malaria Worker project in Cambodia

(2012) Junko Yasuoka et al.   MALARIA JOURNAL

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

(2012) Nicholas J White et al.   MALARIA JOURNAL

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of September 2012 meeting

(2012)   MALARIA JOURNAL

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

(2011) Adele M. Lehane et al.   International Journal for Parasitology-Drugs and Drug Resistance

Tracking Origins and Spread of Sulfadoxine-ResistantPlasmodium falciparum dhpsAlleles in Thailand

(2010) Md Tauqeer Alam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective Sweeps and Genetic Lineages of Plasmodium falciparum Drug -Resistant Alleles in Ghana

(2010) Md Tauqeer Alam et al.   JOURNAL OF INFECTIOUS DISEASES

Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine

(2010) Shabana Ali et al.   MALARIA JOURNAL

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum

(2010) Sumiti Vinayak et al.   PLoS Pathogens

Mass Drug Administration and Integrated Control for the World's High-Prevalence Neglected Tropical Diseases

(2009) PJ Hotez   CLINICAL PHARMACOLOGY & THERAPEUTICS

The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia

(2009) Richard J Maude et al.   MALARIA JOURNAL

Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

(2009) Nicholas J White et al.   MALARIA JOURNAL

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spread and evolution of Plasmodium falciparum drug resistance

(2009) Toshihiro Mita et al.   PARASITOLOGY INTERNATIONAL

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Pharmacokinetic Determinants of the Window of Selection for Antimalarial Drug Resistance

(2008) K. Stepniewska et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

(2008) J. Tarning et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum

(2008) R. K. Mehlotra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Antifolate resistance in Africa and the 164-dollar question

(2008) John E. Hyde   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE