Article
Engineering, Biomedical
Miguel Angel Camara-Vazquez, Ismael Hernandez-Romero, Miguel Rodrigo, Felipe Alonso-Atienza, Carlos Figuera, Eduardo Morgado-Reyes, Felipe Atienza, Maria S. Guillem, Andreu M. Climent, Oscar Barquero-Perez
Summary: This study proposes an ECGI method that incorporates intracardiac measurements as a constraint, with more reliable and accurate reconstructions compared to the classical Tikhonov approach in atrial fibrillation conditions. The method shows more accurate spatial mass functions and outperforms the classical Tikhonov approach when tested on real patient data. Further research will focus on endocardium-epicardium bilayer model approximations and validation using more real patient data.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Cardiac & Cardiovascular Systems
Kei Woldendorp, James Farag, Sam Khadra, Deborah Black, Benjamin Robinson, Paul Bannon
Summary: Postoperative atrial fibrillation (POAF) is common after cardiac surgery and is associated with significantly higher rates of both short-term and long-term stroke and mortality, as well as increased hospital stay. Differences in long-term survival hazard may be due to the underlying pathophysiological risk factors for POAF, which differ by surgical procedure.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Beyer, Lyudmyla Tokarska, Markus Stuhlinger, Gudrun Feuchtner, Florian Hintringer, Sarah Honold, Lukas Fiedler, Marie-Sophie Schonbauer, Robert Schonbauer, Fabian Plank
Summary: Atrial wall thickness, epicardial fat volume, and attenuation are associated with AF recurrence in patients undergoing ablation therapy.
JACC-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Tulio Caldonazo, Hristo Kirov, Mohamed Rahouma, N. Bryce Robinson, Michelle Demetres, Mario Gaudino, Torsten Doenst, POAF MA Grp
Summary: This study conducted a systematic review and meta-analysis to assess the association between new-onset postoperative atrial fibrillation (POAF) after cardiac surgery and perioperative and long-term outcomes. The results showed that POAF was associated with an increased occurrence of various cardiovascular adverse events in the short and long term. However, the causal relationship of this association remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Genetics & Heredity
Junjie Liu, Ximao Liu, Yucheng Luo, Fangze Huang, Yu Xie, Shaoyi Zheng, Bo Jia, Zezhou Xiao
Summary: Sphingolipids play a crucial role in tissue fibrosis, including cardiac fibrosis, and are important for the development of atrial fibrillation. Understanding the impact of sphingolipid levels on cardiac fibrosis can lead to innovative therapeutic strategies for addressing fibrosis and atrial fibrillation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan R. Kuenzel, Maximilian Hoffmann, Silvio Weber, Karolina Kuenzel, Susanne Kaemmerer, Mario Guenscht, Erik Klapproth, Johanna S. E. Rausch, Mirna S. Sadek, Tomasz Kolanowski, Stefanie Meyer-Roxlau, Christopher Piorkowski, Sems M. Tugtekin, Stefan Rose-John, Xiaoke Yin, Manuel Mayr, Jan Dominik Kuhlmann, Pauline Wimberger, Konrad Gruetzmann, Natalie Herzog, Jan-Heiner Kuepper, Molly O'Reilly, S. Nashitha Kabir, Laura C. Sommerfeld, Kaomei Guan, Ben Wielockx, Larissa Fabritz, Stanley Nattel, Ursula Ravens, Dobromir Dobrev, Michael Wagner, Ali El-Armouche
Summary: This study aims to investigate the interplay between PLK2 and OPN in the pathogenesis of atrial fibrosis and AF, finding that PLK2 deficiency is associated with atrial fibrosis and AF occurrence. Regulating the PLK2/ERK1/2/OPN axis may serve as an innovative target for preventing fibrosis progression in AF.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Rachel Eikelboom, Rohan Sanjanwala, Me-Linh Le, Michael H. Yamashita, Rakesh C. Arora
Summary: POAF after cardiac surgery is associated with increased long-term risk of death, highlighting the need for comprehensive prevention and management strategies, including strict follow-up post-discharge. Inconsistent definitions and exclusion criteria for POAF in current studies may impact the accuracy of adjusted analyses. Further research is necessary to elucidate the underlying mechanisms linking POAF and long-term mortality.
ANNALS OF THORACIC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Xixiao Li, Anna Garcia-Elias, Begona Benito, Stanley Nattel
Summary: This article reviews the direct effects of stretch on cardiac fibroblasts, discussing the similarities and differences among studies in observed effects, the signaling pathways involved, and the factors affecting stretch-related phenotypes. The evidence regarding direct fibroblast activation by stretch is deemed weak and inconsistent, and further research is needed to clarify this issue.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
M. Pille, A. Gapelyuk, K. Berg, S. Bannasch, J. Mockler, L. -S Park, J. -W Park, N. Wessel
Summary: This study explored the use of cardiac magnetic field mapping to detect patients with clinically suspected myocarditis, providing a rapid, non-invasive, and cost-effective screening method. By analyzing historical and recent data, using Kullback-Leibler entropy for dimensionality reduction and topological quantification, and applying linear discriminant analysis, the study successfully distinguished between myocarditis patients and healthy controls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Kaiyue He, Xujian Feng, Ziqian Wu, Cuiwei Yang, Zhong Wu, Ying Chen
Summary: This study successfully predicted atrial fibrillation (AF) inducibility using a controllable canine model with various sinus rhythms. By utilizing signal preprocessing, classifiers, and network mapping analysis, the researchers demonstrated the feasibility of AF inducibility prediction, especially with superior spatiotemporal analysis. The high accuracies observed in this study may help evaluate the recurrence of AF after ablation, showcasing the potential of network mapping in AF research.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Cardiac & Cardiovascular Systems
Chang-Hao Xu, Feng Xiong, Wei-Feng Jiang, Xu Liu, Tao Liu, Mu Qin
Summary: Despite significant progress in understanding atrial fibrillation, there are still challenges in its treatment. The review focuses on the rotor mechanism and compares recent clinical approaches to identifying rotors. Though initial studies have shown promising results in rotor ablation, there are some inconclusive outcomes. Hence, there is a need to improve the resolution of mapping techniques and address limitations in current research methodology.
Article
Oncology
Suzanne Lydiard, Beau Pontre, Nicholas Hindley, Boris S. Lowe, Giuseppe Sasso, Paul Keall
Summary: This study developed and evaluated MRI-guided tracking methods for cardiac-induced AF CR targets, showing promising results with small tracking errors in both healthy participants and AF patients. Direct tracking on non-cardiac-gated cine images, however, presented some challenges with overlapping or missing target areas.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Miguel Rodrigo, Kian Waddell, Sarah Magee, Albert J. Rogers, Mahmood Alhusseini, Ismael Hernandez-Romero, Alejandro Costoya-Sanchez, Alejandro Liberos, Sanjiv M. Narayan
Summary: This study suggests that non-invasive estimation of atrial activation rates is feasible and provides a moderate estimate of intracardiac recording rates in regional AF studies when filtered by high spectral organization. Non-invasive technology could be an effective tool to identify patients who may respond to AF ablation for personalized therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Tiago P. Almeida, Diogo C. Soriano, Michela Mase, Flavia Ravelli, Arthur S. Bezerra, Xin Li, Gavin S. Chu, Joao Salinet, Peter J. Stafford, G. Andre Ng, Fernando S. Schlindwein, Takashi Yoneyama
Summary: Utilizing unsupervised classification and AEG-derived markers, five distinct classes of AEGs were identified with significant differences in characteristics, potentially offering a more comprehensive substrate characterization for ablation target identification in future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)