Current strategies to induce secondary metabolites from microbial biosynthetic cryptic gene clusters

The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor

(2017) Sanne Westhoff et al.   ISME Journal

Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides

(2017) Ruidong Chen et al.   ORGANIC LETTERS

Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.

(2016) Min Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome mining approach for harnessing the cryptic gene cluster in Alternaria solani: production of PKS–NRPS hybrid metabolite, didymellamide B

(2016) Takahiro Ugai et al.   TETRAHEDRON LETTERS

Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference

(2015) Sheila M. Pimentel-Elardo et al.   ACS Chemical Biology

Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.

(2015) Yu Imai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthetic biology advances for pharmaceutical production

(2015) Rainer Breitling et al.   CURRENT OPINION IN BIOTECHNOLOGY

Teixobactin, the first of a new class of antibiotics discovered by iChip technology?

(2015) Laura J. V. Piddock   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An irresistible newcomer

(2015) Gerard Wright   NATURE

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Socially mediated induction and suppression of antibiosis during bacterial coexistence

(2015) Monica I. Abrudan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17

(2014) Marius Spohn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

Recent advances in genome-based polyketide discovery

(2014) Eric JN Helfrich et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microbial co-culture: harnessing intermicrobial signaling for the production of novel antimicrobials

(2014) Suzy C Moody   Future Microbiology

Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms

(2014) Andreas Marmann et al.   Marine Drugs

Perspective: Synthetic biology revives antibiotics

(2014) Gerard Wright   NATURE

Fast and sensitive protein alignment using DIAMOND

(2014) Benjamin Buchfink et al.   NATURE METHODS

Exo-Metabolome of Pseudovibrio sp. FO-BEG1 Analyzed by Ultra-High Resolution Mass Spectrometry and the Effect of Phosphate Limitation

(2014) Stefano Romano et al.   PLoS One

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic manipulation of a filamentous fungus by the proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite

(2014) Karen M. VanderMolen et al.   RSC Advances

Targeted Capture and Heterologous Expression of the Pseudoalteromonas Alterochromide Gene Cluster in Escherichia coli Represents a Promising Natural Product Exploratory Platform

(2014) Avena C. Ross et al.   ACS Synthetic Biology

Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery

(2014) Jens Klein et al.   ACS Synthetic Biology

Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus

(2013) Claudia C. König et al.   CHEMBIOCHEM

Detection of metabolite induction in fungal co-cultures on solid media by high-throughput differential ultra-high pressure liquid chromatography–time-of-flight mass spectrometry fingerprinting

(2013) Samuel Bertrand et al.   JOURNAL OF CHROMATOGRAPHY A

Genome-guided discovery of diverse natural products from Burkholderia sp.

(2013) Xiangyang Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Triggers and cues that activate antibiotic production by actinomycetes

(2013) Hua Zhu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

(2013) Brian O. Bachmann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

De Novo Production of Metabolites by Fungal Co-culture of Trichophyton rubrum and Bionectria ochroleuca

(2013) Samuel Bertrand et al.   JOURNAL OF NATURAL PRODUCTS

Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis

(2013) Antonius R. B. Ola et al.   JOURNAL OF NATURAL PRODUCTS

VeA and MvlA repression of the cryptic orsellinic acid gene cluster inAspergillus nidulansinvolves histone 3 acetylation

(2013) Jin Woo Bok et al.   MOLECULAR MICROBIOLOGY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models

(2013) Barzan I. Khayatt et al.   PLoS One

Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

(2013) Yunzi Luo et al.   Nature Communications

Refactoring the Silent Spectinabilin Gene Cluster Using a Plug-and-Play Scaffold

(2013) Zengyi Shao et al.   ACS Synthetic Biology

Microbial Strain Prioritization Using Metabolomics Tools for the Discovery of Natural Products

(2012) Yanpeng Hou et al.   ANALYTICAL CHEMISTRY

Diversity and Natural Functions of Antibiotics Produced by Beneficial and Plant Pathogenic Bacteria

(2012) Jos M. Raaijmakers et al.   Annual Review of Phytopathology

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

(2012) Arryn Craney et al.   CHEMISTRY & BIOLOGY

Global transcriptional responses to triclosan exposure in Pseudomonas aeruginosa

(2012) Rungtip Chuanchuen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

(2012) Yu Imai et al.   JOURNAL OF ANTIBIOTICS

Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans

(2012) Anindita Sarkar et al.   JOURNAL OF BIOTECHNOLOGY

Activation of the Dormant Secondary Metabolite Production by Introducing Gentamicin-Resistance in a Marine-Derived Penicillium purpurogenum G59

(2012) Yun-Jing Chai et al.   Marine Drugs

Regulation of fungal secondary metabolism

(2012) Axel A. Brakhage   NATURE REVIEWS MICROBIOLOGY

Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

(2012) Pep Charusanti et al.   PLoS One

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

(2012) Nadine Ziemert et al.   PLoS One

Unsuspected control of siderophore production byN-acetylglucosamine in streptomycetes

(2012) Matthias Craig et al.   Environmental Microbiology Reports

Scandium Stimulates the Production of Amylase and Bacilysin in Bacillus subtilis

(2011) Takashi Inaoka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

NRPSsp: non-ribosomal peptide synthase substrate predictor

(2011) Carlos Prieto et al.   BIOINFORMATICS

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Dual transcriptional profiling of a bacterial/fungal confrontation: Collimonas fungivorans versus Aspergillus niger

(2011) Francesca Mela et al.   ISME Journal

Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains inAspergillus nidulans

(2011) Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Cryptic Products of the Gliotoxin Gene Cluster Using NMR-Based Comparative Metabolomics and a Model for Gliotoxin Biosynthesis

(2011) Ry R. Forseth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239

(2011) R. Novakova et al.   MICROBIOLOGY-SGM

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Actions for Antibiotics

(2011) W. C. Ratcliff et al.   SCIENCE

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

How to discover new antibiotics: harvesting the parvome

(2010) Julian Davies   CURRENT OPINION IN CHEMICAL BIOLOGY

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

The permease genenagE2is the key toN-acetylglucosamine sensing and utilization inStreptomyces coelicolorand is subject to multi-level control

(2010) Harald Nothaft et al.   MOLECULAR MICROBIOLOGY

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

SBSPKS: structure based sequence analysis of polyketide synthases

(2010) Swadha Anand et al.   NUCLEIC ACIDS RESEARCH

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3

(2009) Jeffrey A. Dietrich et al.   ACS Chemical Biology

Hollow-Fiber Membrane Chamber as a Device for In Situ Environmental Cultivation

(2009) Y. Aoi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cultivation of Fastidious Bacteria by Viability Staining and Micromanipulation in a Soil Substrate Membrane System

(2009) B. C. Ferrari et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bad Bugs, No Drugs: No ESCAPE Revisited

(2009) Lance R. Peterson   CLINICAL INFECTIOUS DISEASES

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY

Identification and Functional Characterization of an afsR Homolog Regulatory Gene from Streptomyces venezuelae ATCC 15439

(2009) Jae Kyung Sohng   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

A proteomics approach to discovering natural products and their biosynthetic pathways

(2009) Stefanie B Bumpus et al.   NATURE BIOTECHNOLOGY

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Production of Pyomelanin, a Second Type of Melanin, via the Tyrosine Degradation Pathway in Aspergillus fumigatus

(2008) J. Schmaler-Ripcke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Construction of a Citrinin Gene Cluster Expression System in Heterologous Aspergillus oryzae

(2008) Kanae Sakai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

Fluorescent Profiling of Modular Biosynthetic Enzymes by Complementary Metabolic and Activity Based Probes

(2008) Jordan L. Meier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodostreptomycins, Antibiotics Biosynthesized Following Horizontal Gene Transfer fromStreptomyces padanustoRhodococcus fascians

(2008) Kazuhiko Kurosawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

(2008) S. E. Maddocks et al.   MICROBIOLOGY-SGM

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster fromStreptomyces cattleya

(2008) Miriam Rodríguez et al.   MOLECULAR MICROBIOLOGY

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium

(2008) Klas Flärdh et al.   NATURE REVIEWS MICROBIOLOGY

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH