Journal
ANNALS OF HEMATOLOGY
Volume 97, Issue 4, Pages 679-684Publisher
SPRINGER
DOI: 10.1007/s00277-017-3223-3
Keywords
beta-Thalassemia major; Iron overload; Oxidative stress; AGEs; sLOX-1
Categories
Funding
- Hyperlipidemia Research Center at the Ahvaz Jundishapur University of Medical Sciences
- [HRC-9308]
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The impaired biosynthesis of the beta-globin chain in beta-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major beta-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects. Metabolic parameters including glycemic and iron indices, hepatic and renal functions tests, oxidative stress markers, and AGEs (carboxymethyl-lysine and pentosidine) levels were measured. All parameters were significantly increased in beta-thalassemia compared to the control except for glutathione levels. Blood glucose, iron, serum ferritin, non-transferrin-bound iron (NTBI), MDA, soluble form of low-density lipoprotein receptor, glutathione peroxidase, total reactive oxygen species (ROS), and AGE levels were significantly higher in the beta-thalassemia patients. Iron and ferritin showed a significant positive correlation with pentosidine (P < 0.01) but not with carboxymethyl-lysine. The NTBI was markedly increased in the beta-thalassemia patients, and its levels correlated significantly with both carboxymethyl-lysine and pentosidine (P < 0.05). Our findings confirm the oxidative status generated by the iron overload in beta-thalassemia major patients and highlight the enhanced formation of AGEs, which may play an important role in the pathogenesis of beta-thalassemia major.
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