The urokinase-type plasminogen activator (uPA) system as a biomarker and therapeutic target in human malignancies

PTEN expression in endothelial cells is down-regulated by uPAR to promote angiogenesis

(2015) Matthias Unseld et al.   THROMBOSIS AND HAEMOSTASIS

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme

(2015) Anna Laurenzana et al.   Oncotarget

Involvement of Urokinase-Type Plasminogen Activator System in Cancer: An Overview

(2014) Ahmed H. Mekkawy et al.   MEDICINAL RESEARCH REVIEWS

Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration

(2014) Sujoy Dutta et al.   Molecular Oncology

PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

(2014) Khalid Bajou et al.   NATURE MEDICINE

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer

(2013) Swapna Asuthkar et al.   MOLECULAR BIOLOGY OF THE CELL

Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target

(2013) Kuan-Chung Hsiao et al.   PLoS One

The Apparent uPA/PAI-1 Paradox in Cancer: More than Meets the Eye

(2013) Andrew Mazar et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Role of Urokinase Receptor in Tumor Progression and Development

(2013) Hyangsoon Noh et al.   Theranostics

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Plasminogen activator inhibitor-1 promotes the proliferation and inhibits the apoptosis of pulmonary fibroblasts by Ca2+ signaling

(2012) Yan-Ping Zhang et al.   THROMBOSIS RESEARCH

Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2011) Manfred Schmitt et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

(2011) Hari Raghu et al.   Molecular Cancer

Vitronectin in Vascular Context: Facets of a Multitalented Matricellular Protein

(2011) Klaus Preissner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Inhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor

(2010) Xian-wen Hu et al.   CANCER BIOLOGY & THERAPY

Modulators of the urokinase-type plasminogen activation system for cancer

(2010) Ralf Hildenbrand et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Urokinase Plasminogen Activator System: A Target for Anti-Cancer Therapy

(2009) Salvatore Ulisse et al.   CURRENT CANCER DRUG TARGETS

Urokinase plasminogen activator system as a potential target for cancer therapy

(2009) Ahmed H Mekkawy et al.   Future Oncology

Reversibility of Epithelial-Mesenchymal Transition (EMT) Induced in Breast Cancer Cells by Activation of Urokinase Receptor-dependent Cell Signaling

(2009) Minji Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness

(2009) Nataša Obermajer et al.   Molecular Cancer

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Computer Aided Identification of Small Molecules Disrupting uPAR/α5β1- Integrin Interaction: A New Paradigm for Metastasis Prevention

(2009) Pratima Chaurasia et al.   PLoS One

Nuclear translocation of urokinase-type plasminogen activator

(2008) V. Stepanova et al.   BLOOD

The interaction between urokinase receptor and vitronectin in cell adhesion and signalling

(2008) C MADSEN et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Tumor microenvironment and angiogenesis

(2008) Pia Nyberg   Frontiers in Bioscience-Landmark

Plasminogen activator inhibitor-1 inhibits prostate tumor growth through endothelial apoptosis

(2008) S.-C. Chen et al.   MOLECULAR CANCER THERAPEUTICS