Novel therapeutic targets of metformin: metabolic syndrome and cardiovascular disease

Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes

(2015) Ricardo Fontes-Carvalho et al.   Cardiovascular Diabetology

METformin in DIastolic Dysfunction of MEtabolic Syndrome (MET-DIME) Trial: Rationale and Study Design

(2014) Ricardo Ladeiras-Lopes et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes

(2014) Chris P. H. Lexis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Global Burden of Cardiovascular Disease

(2014) Valentin Fuster   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

(2013) Peter M Schmid et al.   Cardiovascular Diabetology

Chronic Metformin Treatment is Associated with Reduced Myocardial Infarct Size in Diabetic Patients with ST-segment Elevation Myocardial Infarction

(2013) Chris P. H. Lexis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Metformin Therapy in Diabetes: The Role of Cardioprotection

(2013) Saloua El Messaoudi et al.   Current Atherosclerosis Reports

Standards of Medical Care in Diabetes--2014

(2013)   DIABETES CARE

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Impact of Obesity and the Obesity Paradox on Prevalence and Prognosis in Heart Failure

(2013) Carl J. Lavie et al.   JACC-Heart Failure

Adipokines Mediate Inflammation and Insulin Resistance

(2013) Hyokjoon Kwon et al.   Frontiers in Endocrinology

Inflammation and metabolic dysfunction: links to cardiovascular diseases

(2012) Annika Taube et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model

(2012) A. Cittadini et al.   DIABETES

Metformin-based treatment for obesity-related hypertension

(2012) Hongbo He et al.   JOURNAL OF HYPERTENSION

Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk

(2012) Scott M. Grundy   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance

(2012) Rozalina G. McCoy et al.   MAYO CLINIC PROCEEDINGS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin Sensitization Therapy and the Heart

(2012) Aaron K.F. Wong et al.   Heart Failure Clinics

Heart in Diabetes: Not Only a Macrovascular Disease

(2011) B. Stratmann et al.   DIABETES CARE

Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats

(2011) Adriana K. Burlá et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of Obesity and Overweight on Left Ventricular Diastolic Function

(2011) Cesare Russo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrated backscatter as a fibrosis marker in the metabolic syndrome: association with biochemical evidence of fibrosis and left ventricular dysfunction

(2011) W. Kosmala et al.   European Heart Journal-Cardiovascular Imaging

Globular and Full-Length Adiponectin Induce NO-Dependent Vasodilation in Resistance Arteries of Zucker Lean but Not Zucker Diabetic Fatty Rats

(2010) P. M. Schmid et al.   AMERICAN JOURNAL OF HYPERTENSION

Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors

(2010) John T. Heiker et al.   BIOLOGICAL CHEMISTRY

Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway

(2010) Han Xiao et al.   CARDIOVASCULAR RESEARCH

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats

(2010) Cheng-Xi Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of Nonischemic Myocardial Fibrosis

(2010) Christine Jellis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration

(2009) H. Nakai et al.   European Journal of Echocardiography

Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor

(2009) Marta Paiva et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial

(2009) Neera Agarwal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population

(2008) Kazuo Eguchi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Meta-analysis: Metformin Treatment in Persons at Risk for Diabetes Mellitus

(2008) Shelley R. Salpeter et al.   AMERICAN JOURNAL OF MEDICINE

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease

(2008) Sanjeev B. Patel et al.   CURRENT HYPERTENSION REPORTS