Article
Critical Care Medicine
Tiantian Wu, Chao Ren, Xiaowei Dou, Yao Wu, Ning Dong, Hui Zhang, Yongming Yao
Summary: Immunosuppression plays a crucial role in sepsis development and is closely associated with poor outcomes. This study investigated the novel role of the anti-inflammatory cytokine IL-35 in sepsis. Results showed that IL-35 inhibited CD4(+) T cell proliferation and the Th1/Th2 ratio, and exerted immunosuppressive effects by suppressing HMGB1-dependent autophagy.
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Article
Nutrition & Dietetics
Laura Kate Gadanec, Ulf Andersson, Vasso Apostolopoulos, Anthony Zulli
Summary: High levels of HMGB-1 have been found in patients with Hyperhomocysteinemia (HHcy), which worsens cardiovascular outcomes. Targeting HMGB-1 may be a potential therapy for improving HHcy-induced cardiovascular pathologies.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Shuhua Wu, Yangyang Yu, Zhong Zheng, Qi Cheng
Summary: This article elaborates on the role and mechanism of HMGB1 in allergic rhinitis (AR), highlighting its potential value as a new target for clinical research on AR treatment. AR is a prevalent chronic inflammatory disease and current management focuses on symptom control.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wataru Takaki, Hirotaka Konishi, Daiki Matsubara, Katsutoshi Shoda, Tomohiro Arita, Satoshi Kataoka, Jun Shibamoto, Hirotaka Furuke, Kazuya Takabatake, Hiroki Shimizu, Shuhei Komatsu, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji
Summary: This study reveals that extracellular HMGB1 promotes the progression and metastasis of gastric cancer, and plasma HMGB1 concentrations can serve as a prognostic marker in gastric cancer patients. Recombinant human soluble thrombomodulin (rTM) targeting HMGB1 shows potential therapeutic effects in gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xinfang Yu, Li Zhou, Wenbin Liu, Lijun Liu, Feng Gao, Wei Li, Haidan Liu
Summary: Skp2 is highly expressed in human colorectal cancer and plays a role in promoting tumorigenesis by stabilizing Mcl-1. Blocking Skp2 expression reduces tumorigenic properties of CRC cells, while Skp2 deficiency enhances sensitivity of CRC cells to irradiation treatments.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Chang-Fang Chiu, Shih-Jiuan Chiu, Li-Yuan Bai, Chia-Hsien Feng, Jing-Lan Hu, Wei-Yu Lin, Hao-Yu Huang, Jing-Ru Weng
Summary: The study showed that JBIR-100 could inhibit proliferation and induce apoptosis in breast cancer cells by modulating the Akt/NF-kappa B signaling pathway and Bcl-2 family members. Additionally, JBIR-100 also inhibited autophagy in MCF-7 cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: After retinal detachment, the lack of HMGB1 accelerates photoreceptor cell death by reducing protective autophagy activation. The diminished autophagy levels in HMGB1 Delta rod retinas lead to increased apoptotic cell death in detached retinas.
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Oncology
Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Summary: This study aims to investigate the mechanism of MCL-1i-induced Mcl-1 protein stability. Both in vivo and in vitro experiments demonstrate that MCL-1i-induced Mcl-1 protein stability is mainly associated with defective Mcl-1 ubiquitination and concurrent apoptosis induction. Additionally, MCL-1i also enhances Mcl-1Thr163 phosphorylation via ERK pathway, contributing to Mcl-1 stability.
CLINICAL CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Wanying Shan, Liang Xu, Zhuoyin Qiu, Jingwen Wang, Jiaxing Shao, Jie Feng, Jie Zhao
Summary: This study aimed to investigate whether high-mobility group box 1 (HMGB1) levels could predict post-stroke depression (PSD) at 3 months after acute ischemic stroke. The results demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with an increased risk of PSD, with an optimal cutoff point of 8.6 ng/mL showing good sensitivity and specificity for predicting PSD.
NEUROLOGICAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chiao-Wen Lin, Yi-Tzu Chen, Hsieh-Hsun Ho, Pei-Shan Hsieh, Yi-Wei Kuo, Jia-Hung Lin, Cheng-Ruei Liu, Yu-Fen Huang, Ching-Wei Chen, Chen-Hung Hsu, Wen-Yang Lin, Shun-Fa Yang
Summary: The study showed that oral probiotic lozenges significantly increased the population of Lactobacillus in the oral cavity and exhibited antibacterial activity within two weeks. IgA levels, Lactobacillus and Bifidobacterium abundances in the oral cavity were significantly increased in the experimental groups, leading to reduced plaque formation. Most participants experienced improved oral health and intestinal symptoms.
Editorial Material
Otorhinolaryngology
Pei-Hsuan Wu, Chia-Yi Lee, Jing-Yang Huang, Shun-Fa Yang, Cheng-Ping Shih
Summary: Low gestational age, low birth weight, and a long disease course are significantly correlated with late-onset SNHL in patients with cCMV infection.
CLINICAL OTOLARYNGOLOGY
(2022)
Article
Environmental Sciences
Cheng-Chen Huang, Chun-Wen Su, Po-Hui Wang, Yen-Ting Lu, Yu-Ting Ho, Shun-Fa Yang, Chung-Han Hsin, Chiao-Wen Lin
Summary: This study found that dihydromyricetin (DHM) inhibited the migration and invasion of nasopharyngeal carcinoma (NPC) cells by suppressing the expression of matrix metalloproteinases-2 (MMP-2) via down regulating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Kung-Ssu Yang, Pi-Cheng Che, Ming-Ju Hsieh, I-Neng Lee, Yu-Ping Wu, Ming-Shan Chen, Jui-Chieh Chen
Summary: This study found that propofol has anti-cancer effects on oral squamous cell carcinoma (OSCC) and attenuates the secretion of multiple growth factors. Further research revealed that the expression of AREG is related to poor prognosis and drug resistance, and propofol decreases AREG expression and alleviates drug resistance. Therefore, propofol combination therapy may serve as an effective treatment strategy for OSCC.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Ming-Yu Hsieh, Ming-Ju Hsieh, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mu-Kuan Chen, Ming-Chih Chou
Summary: The study found that Xanthohumol has a significant apoptotic effect and anticancer properties in human NPC cell lines, by regulating apoptosis-related proteins and the MAPK JNK pathway to promote cell apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Immunology
Yia-Ting Li, Yao-Chen Wang, Shun-Fa Yang, Yat-Yin Law, Bei-Hao Shiu, Te-An Chen, Shih-Chi Wu, Min-Chi Lu
Summary: This study aimed to identify the risk factors of invasive Candida infection (ICI) in surgical critically ill peptic ulcer patients. The results indicated that blood lactate level measured at hospital admission could be a predictor of ICI, and patients with liver cirrhosis and higher Sequential Organ Failure Assessment (SOFA) score had poor outcomes.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Pediatrics
Yu-Jung Chang, Grace Hao, Anpin Ni, Thomas Layton, Jing-Yang Huang, Shun-Fa Yang, Shiuan-Chih Chen
Summary: This study aims to evaluate guidelines for initiating oral feeding in preterm infants and finds that using the Taiwan version of Preterm Oral Feeding Readiness Assessment Scale (TW-POFRAS) in clinical decision-making can help preterm infants to start oral feeding at the appropriate time. For most preterm infants, they can smoothly consume at least 5 mL of milk in one meal and proceed to consume a full day of meals within a week. The average length of stay in the hospital is typically one month, except for infants with a birth weight less than 1,500 g or a gestational age less than 32 weeks.
PEDIATRICS AND NEONATOLOGY
(2022)
Article
Oncology
Hsueh-Ju Lu, Chih-Yu Peng, Hsien-Chun Tseng, Chung-Han Hsin, Chun-Yi Chuang, Chun-Chia Chen, Wei-Shiou Huang, Yu-Wei Chiu, Shun-Fa Yang
Summary: This study retrospectively analyzed 262 patients with OCSCC and divided them into resectable and unresectable groups. The study found that salvage surgery had an impact on the survival of OCSCC patients and established a scoring model to predict life expectancy after salvage surgery.
Article
Multidisciplinary Sciences
Shih-Ching Lo, Kevin Sheng-Kai Ma, Yen-Ru Li, Zi-Yue Li, Cheng-Hung Lin, Hsing-Chun Lin, Shun-Fa Yang
Summary: There is an association between nutritional provision and successful weaning from ventilators, suggesting that adequate nutrition support may increase the chances of successful extubation in patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Mu-Kuei Shieu, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Yi-Ching Chuang, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrated the antimetastatic effects of narciclasine in oral cancer and identified the underlying molecular mechanisms. Narciclasine inhibits oral cancer metastasis by regulating the ERK pathway and CTSB, providing potential targets for oral cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yang
Summary: This study aimed to investigate the relationship between TIMP3 genetic polymorphisms and biochemical recurrence and clinicopathological features of prostate cancer. It was found that the TIMP3 rs9619311 genetic polymorphism was significantly associated with susceptibility to biochemical recurrence of prostate cancer. Moreover, in patients with a PSA concentration under 7 ng/mL, the TIMP3 rs9619311 genetic polymorphism was associated with Gleason total score upgrade and grade group upgrade.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ming-Ju Hsieh, Hsin-Yu Ho, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Mosleh Mohammad Abomughaid, Ming-Chang Hsieh, Mu-Kuan Chen
Summary: The study investigates the anticancer activities of a natural compound called semilicoisoflavone B (SFB) in oral squamous cell carcinoma (OSCC). Results show that SFB reduces cell viability by targeting the cell cycle and inducing apoptosis. It also inhibits several signaling pathways and downregulates survivin expression. Overall, the study suggests that SFB has potential as a therapeutic agent for human OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
