Article
Endocrinology & Metabolism
H. K. Datta, J. Vila, S. P. Tuck
Summary: Osteogenesis imperfecta is a rare disorder caused by mutations in collagen type I genes, leading to fractures and deformity. The effectiveness of bisphosphonates in adult OI patients remains unclear, with small trials showing increases in BMD without reducing fracture rates.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Bo Freyschuss, Maria K. Svensson, Thomas Cars, Lars Lindhagen, Helena Johansson, Andreas Kindmark
Summary: Real-world evidence from Sweden's largest healthcare region demonstrates low uptake of antiresorptive treatment but beneficial effects for individuals receiving treatment, particularly for the composite outcome of hip fracture or death.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ami Lee, Hyun Yang, Taesoo Kim, Hyunil Ha, Youn-Hwan Hwang
Summary: This study utilized a pharmacokinetic approach to identify bioavailable components in Psoralea corylifolia extracts and found that certain constituents of PC could benefit bone health.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Sagar Salave, Dhwani Rana, Hemant Kumar, Nagavendra Kommineni, Derajram Benival
Summary: The present study aimed to develop PTH (1-34)-loaded stealth nanoliposomes (PTH-LPs) using the Quality by Design (QbD) approach and evaluate their biocompatibility and osteogenic potential on osteoblast-like cells. The results demonstrated that lipid concentration had a positive impact on particle size and %EE, while cholesterol concentration reduced %EE.
Article
Endocrinology & Metabolism
F. Gossiel, A. Ugur, N. F. A. Peel, J. S. Walsh, R. Eastell
Summary: TRACP-5b is not affected by food intake and has similar diagnostic accuracy to CTX and PINP in monitoring the response to osteoporosis treatment.
OSTEOPOROSIS INTERNATIONAL
(2022)
Editorial Material
Medicine, General & Internal
Kristine E. Ensrud, John T. Schousboe
Summary: Medications used to reduce the risk of osteoporosis-related fractures are classified as antiresorptive agents or anabolic therapies. This article focuses on anabolic medications, including specific drugs like teriparatide, abaloparatide, and romosozumab.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Alvaro del Real, Sergio Ciordia, Carolina Sanudo, Carmen Garcia-Ibarbia, Adriel Roa-Bautista, Javier G. Ocejo-Vinals, Fernando Corrales, Jose A. Riancho
Summary: The aim of this study was to explore new markers in serum proteome associated with the response to antiosteoporosis drugs. The results showed significant differences in protein levels, particularly those related to the innate immune system, in the serum after treatment with teriparatide and denosumab.
Article
Endocrinology & Metabolism
Ji Sup Hwang, Sanguk Lee, Hyun Sik Gong
Summary: This study found that in patients with recent distal radius fractures receiving oral anti-resorptive agents, bone turnover markers decreased significantly at six months, and the percentage decrease could predict improvements in bone mineral density at one year. Bisphosphonate users had higher sensitivity and specificity, while SERM users did not have identifiable cutoff points. Adjusted cutoff points may be necessary to increase sensitivity for detecting patients responsive to ARA treatment after a new DRF.
Article
Medicine, Research & Experimental
Yi Zhong, Azhao Li, Jianrong Luo, Fengling Chen
Summary: This paper reviews the practical application and potential value of bone turnover markers in evaluating and monitoring osteoporosis treatments, emphasizing their role in improving treatment efficacy and reducing fracture risk in clinical practice.
DISCOVERY MEDICINE
(2021)
Article
Medical Laboratory Technology
Gregory A. Kline, Daniel T. Holmes
Summary: Bone turnover markers (BTM) are important for understanding the effect of anti-resorptives on osteoclast activity. Post-hoc trial data suggests that a 40% reduction in BTM may represent an appropriate response to therapy. However, applying this target threshold in individual patients is problematic due to measurement uncertainty and natural variation.
CLINICAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Suman Gyanewali, Prashant Kesharwani, Afsana Sheikh, Farhan Jalees Ahmad, Ritu Trivedi, Sushama Talegaonkar
Summary: This study developed and optimized protransfersome formulation for risedronate sodium, aiming to enhance its bioavailability and improve therapeutic efficacy. The optimized formulation showed better pharmacokinetic and pharmacodynamic parameters, with ex vivo studies and CLSM analysis confirming enhanced drug penetration. Biomechanical, biochemical, and histo-pathological studies further validated the results, indicating the great potential of protransfersome formulation in providing better therapeutic efficacy than conventional counterparts.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Seong Cheol Kim, Hyeon Jeong Kim, Gi Eun Park, Ramesh Prasad Pandey, Jisun Lee, Jae Kyung Sohng, Yong Il Park
Summary: This study demonstrated that Tri inhibits osteoclastic cell differentiation and bone resorption by down-regulating the expression of osteoclastogenic marker genes and signalling proteins, bone resorptive proteins, and by augmenting serum OPG/RANKL ratio, suggesting that Tri can be a novel anti-osteoporotic compound for treating senile and postmenopausal OP.
Article
Endocrinology & Metabolism
Martin Frank, Andreas Grabos, Andreas G. Reisinger, David B. Burr, Dieter H. Pahr, Matthew R. Allen, Philipp J. Thurner
Summary: Osteoporosis is commonly treated with bisphosphonates (BPs) and selective estrogen receptor modulators (SERMs), which successfully reduce the risk of fractures but have different effects on bone mass and strength. The study found that material properties of trabecular bone are improved after anti-resorptive treatment, contributing to better understanding of clinically relevant mechanical behavior of bone.
Article
Engineering, Biomedical
Yan Hu, Xiaoqun Li, Qin Zhang, Zhengrong Gu, Ying Luo, Jiawei Guo, Xiuhui Wang, Yingying Jing, Xiao Chen, Jiacan Su
Summary: This study demonstrates a novel approach to target bone marrow through surface display of CXCR4 on exosomes, which are then fused with liposomes carrying antagomir-188 to produce hybrid nanoparticles. These nanoparticles selectively accumulate in bone marrow, release antagomir-188, promote osteogenesis, inhibit adipogenesis, and reverse bone loss conditions, presenting a promising therapeutic strategy for age-related bone loss.
BIOACTIVE MATERIALS
(2021)
Article
Health Care Sciences & Services
Franziska Lademann, Martina Rauner, Nicolas Bonnet, Lorenz C. Hofbauer, Elena Tsourdi
Summary: Bone remodeling and glucose homeostasis are closely related, but suppressing bone remodeling does not affect whole-body glucose homeostasis in male mice with hypothyroidism. However, hypothyroidism leads to changes in glucose handling and glucose uptake in muscle, liver, and epididymal white adipose tissue.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ferenc Emil Mozes, Jenny A. Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswal, Michael Trauner, Jerome Boursier, Celine Fournier, Katharina Staufer, Rudolf E. Stauber, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Monica Lupsor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J. Eddowes, Gideon M. Hirschfield, Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F. Cobbold, Yoshio Sumida, Akira Okajima, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand, Thomas Karlas, Yusuf Yilmaz, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, Geraldine J. Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget, Andreas Geier, Theresa Tuthill, M. Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.
Article
Transplantation
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten Asser Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Mads Hornum, Lenka Bartonova, Eva Honsova, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: This study found that levels of circulating and excreted ETP are associated with kidney function, CKD severity, and the extent of interstitial fibrosis, gradually increasing with higher fibrotic burden. ETP outperformed the known fibrosis biomarker Dickkopf-3 in discriminating patients with high fibrotic burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Orthopedics
V. B. Kraus, M. A. Karsdal
Summary: This article provides an overview of biomarkers for osteoarthritis (OA) and aims to equip non-specialists with a toolbox to understand and utilize biomarkers in the field of OA. Although the importance of molecular biomarkers in OA has been increasingly recognized, no OA-related biomarkers have been widely adopted in clinical practice. However, there is a growing compendium of OA-related biomarkers that could facilitate drug development for OA. The use of appropriate biomarkers is crucial for OA diagnosis, prognosis, drug development, and treatment.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen
Summary: The study found that there was no significant correlation between the content of fatty acids in granulocytes and disease activity in patients with psoriatic arthritis (PsA). However, marine n-3 PUFA was positively correlated with collagen degradation, while n-6 PUFA was positively correlated with collagen formation. Further investigation is needed to explore the relationship between fatty acids and biomarkers of bone and soft tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Majken Lindholm, Antonio Di Sabatino, Tina Manon-Jensen, Giuseppe Mazza, Gunvor Madsen, Paolo Giuffrida, Massimo Pinzani, Aleksander Krag, Morten A. Karsdal, Jens Kjeldsen, Joachim H. Mortensen
Summary: The study demonstrated that serum LG1M levels were elevated in CD patients compared to healthy subjects, indicating a possible association with laminin degradation. In DSS-induced colitis rats, LG1M levels increased upon disease reversal, suggesting ongoing mucosal repair.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Liang-Jie Tang, Hong-Lei Ma, Mohammed Eslam, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Diana Julie Leeming, Morten Karsdal, Gang Li, Ou-Yang Huang, Howard Ho-Wai Leung, Yu-Jie Zhou, Qian Feng, Pei Jiang, Li-Mei Gao, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study evaluated the performance of new biomarkers and algorithms for diagnosing advanced fibrosis in an Asian population. The results showed that the ADAPT score had good accuracy and sensitivity in diagnosing advanced fibrosis, and it outperformed other non-invasive fibrosis biomarkers. The ADAPT score also had good diagnostic performance in subgroup analyses.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cardiac & Cardiovascular Systems
Dania Al-Sharify, Signe Holm Nielsen, Frank Matthes, Christoffer Tengryd, Jiangming Sun, Federica Genovese, Morten A. Karsdal, Jan Nilsson, Isabel Goncalves, Andreas Edsfeldt
Summary: This study investigated the association of cleaved osteoglycin with plaque phenotype and found that higher levels of cleaved osteoglycin were associated with a stable plaque phenotype and lower risk for future cardiovascular events. This association may be due to reduced cell apoptosis and the ability to retain LDL. Targeting the cleavage of osteoglycin may be a potential therapeutic strategy to stabilize plaques.
Article
Rheumatology
Signe Holm Nielsen, Andrew Stahly, Emilie H. Regner, Anne -Christine Bay-Jensen, Morten A. Karsdal, Kristine A. Kuhn
Summary: This study investigated the association between biomarkers of collagen degradation in healthy controls and patients with axSpA, CD, and CD-axSpA. The results showed that degradation of type IV collagen, quantified by C4M, could completely differentiate patients with CD-axSpA from axSpA, CD, and healthy controls, indicating excessive collagen degradation and epithelial turnover. This biomarker has the potential to identify patients affected by both diseases and guide treatment decisions.
JOURNAL OF RHEUMATOLOGY
(2022)
Letter
Dermatology
Signe Holm Nielsen, Solveig Skovlund Groen, Yiqiu Yao, Astrid-Helene Ravn Jorgensen, Valdemar Wendelboe Nielsen, Morten Karsdal, Kristoffer Gehring, Anne-Christine Bay-Jensen, Simon Francis Thomsen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Mette J. Nielsen, Grace E. Dolman, Rebecca Harris, Peder Frederiksen, Jane Chalmers, Jane I. Grove, William L. Irving, Morten A. Karsdal, Keyur Patel, Diana Julie Leeming, Indra Neil Guha
Summary: This study investigated the prognostic value of the fibrogenesis marker PRO-C3 and the ALBI score in predicting clinical outcomes and mortality in two cohorts of compensated cirrhosis patients. The results showed that both PRO-C3 and ALBI were independently associated with liver-related clinical outcomes, suggesting that PRO-C3 may be a valuable predictor of treatment efficacy.
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Nadja Sparding, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsda, Mads Hornum, Bo Feldt-Rasmussen, Rebecca Packington, Nicholas M. Selby
Summary: This study found that levels of plasma ETP were higher in patients with acute kidney injury (AKI) at 1 year compared to those without AKI, and ETP levels predicted kidney disease progression and mortality in AKI patients.
Article
Gastroenterology & Hepatology
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clement, Joern M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Summary: The study found that serum miR-193a-5p levels are strongly correlated with NAFLD activity grade and fibrosis stage. MiR-193a-5p may play a role in the hepatic response to oxidative stress and is a potential circulating biomarker for progressive NAFLD.