Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors

(2015) Christopher J. Lord et al.   Annual Review of Medicine

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response

(2014) Antoni Garcia-Molina et al.   BMC PLANT BIOLOGY

Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria

(2014) Linhong Zhao et al.   CHEMICAL COMMUNICATIONS

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

(2014) Elena V. Polishchuk et al.   DEVELOPMENTAL CELL

Metal Preferences and Metallation

(2014) Andrew W. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer

(2014) Eric S. Kim et al.   LUNG CANCER

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin

(2014) Carlos P. Huang et al.   Metallomics

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Translocation of Platinum Anticancer Drugs by Human Copper ATPases ATP7A and ATP7B

(2013) Francesco Tadini-Buoninsegni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells

(2013) Miguel Arredondo et al.   BIOMETALS

Cisplatin: an old drug with a newfound efficacy – from mechanisms of action to cytotoxicity

(2013) Antonio Macciò et al.   EXPERT OPINION ON PHARMACOTHERAPY

Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies

(2013) Siqing Fu et al.   INVESTIGATIONAL NEW DRUGS

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals

(2013) Zheng Dong Liang et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Atox1 Contains Positive Residues that Mediate Membrane Association and Aid Subsequent Copper Loading

(2013) Adrian G. Flores et al.   JOURNAL OF MEMBRANE BIOLOGY

Divalent metal transporter 1 (Dmt1) Mediates Copper Transport in the Duodenum of Iron-Deficient Rats and When Overexpressed in Iron-Deprived HEK-293 Cells

(2013) Lingli Jiang et al.   JOURNAL OF NUTRITION

The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B

(2013) Roohangiz Safaei et al.   Metallomics

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes

(2013) C. R. Pope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Human High-Affinity Copper Transporter in Copper Homeostasis Regulation and Cisplatin Sensitivity in Cancer Chemotherapy

(2012) M. T. Kuo et al.   CANCER RESEARCH

Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications

(2012) Weiwei Shan et al.   CELL CYCLE

Olaparib, PARP1 inhibitor in ovarian cancer

(2012) Claudia Marchetti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Platinum Concentration and Tumor Response in Non–Small-Cell Lung Cancer

(2012) Eric S. Kim et al.   JOURNAL OF CLINICAL ONCOLOGY

Overcoming Platinum Resistance through the Use of a Copper-Lowering Agent

(2012) Siqing Fu et al.   MOLECULAR CANCER THERAPEUTICS

Mechanistic Basis for Overcoming Platinum Resistance Using Copper Chelating Agents

(2012) Z. D. Liang et al.   MOLECULAR CANCER THERAPEUTICS

The Effect of the Extracellular Domain of Human Copper Transporter (hCTR1) on Cisplatin Activation

(2011) Xinghao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Interaction of Cisplatin with the Human Copper Chaperone Atox1 by Solution and In-Cell NMR Spectroscopy

(2011) Fabio Arnesano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy

(2011) Helen H.W. Chen et al.   LUNG CANCER

Sp1 expression regulates lung tumor progression

(2011) T-I Hsu et al.   ONCOGENE

Copper Metallochaperones

(2010) Nigel J. Robinson et al.   Annual Review of Biochemistry

The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin

(2010) Christopher A. Larson et al.   BIOCHEMICAL PHARMACOLOGY

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

The tightly regulated copper window in yeast

(2010) Seraphine V. Wegner et al.   CHEMICAL COMMUNICATIONS

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the Methionines and Histidines in the Transmembrane Domain of Mammalian Copper Transporter 1 in the Cellular Accumulation of Cisplatin

(2010) C. A. Larson et al.   MOLECULAR PHARMACOLOGY

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

(2010) Feng Long et al.   NATURE

Structures of three distinct activator-TFIID complexes

(2009) W.-L. Liu et al.   GENES & DEVELOPMENT

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1

(2009) Zhengyi Wu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Regulation of copper transport in Arabidopsis thaliana: a biochemical oscillator?

(2009) Lola Peñarrubia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Crystal Structures of Cisplatin Bound to a Human Copper Chaperone

(2009) Amie K. Boal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1

(2009) Sarah E. Crider et al.   Metallomics

Mechanistic Comparison of Human High-Affinity Copper Transporter 1-Mediated Transport between Copper Ion and Cisplatin

(2009) Z. D. Liang et al.   MOLECULAR PHARMACOLOGY

SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis

(2009) H. Yamasaki et al.   PLANT CELL

Three-dimensional structure of the human copper transporter hCTR1

(2009) C. J. De Feo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platinum compounds 30 years after the introduction of cisplatin: Implications for the treatment of ovarian cancer

(2008) Franco Muggia   GYNECOLOGIC ONCOLOGY

Interaction of cisplatin and analogues with a Met-rich protein site

(2008) Chak Ming Sze et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Elevated GSH Level Increases Cadmium Resistance through Down-Regulation of Sp1-Dependent Expression of the Cadmium Transporter ZIP8

(2008) I. Aiba et al.   MOLECULAR PHARMACOLOGY

Elevated Glutathione Levels Confer Cellular Sensitization to Cisplatin Toxicity by Up-Regulation of Copper Transporter hCtr1

(2008) H. H. W. Chen et al.   MOLECULAR PHARMACOLOGY

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells

(2008) I.-S. Song et al.   MOLECULAR PHARMACOLOGY

A place for thioether chemistry in cellular copper ion recognition and trafficking

(2008) Anna V Davis et al.   Nature Chemical Biology

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology