Review
Dermatology
Takeshi Nakahara, Makiko Kido-Nakahara, Gaku Tsuji, Masutaka Furue
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by skin barrier dysfunction, inflammation, and intense itch. The pathophysiology involves abnormalities in filaggrin, intercellular lipids, and tight junctions leading to skin inflammation and itch.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yoshie Umehara, Chanisa Kiatsurayanon, Juan Valentin Trujillo-Paez, Panjit Chieosilapatham, Ge Peng, Hainan Yue, Hai Le Thanh Nguyen, Pu Song, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Itch or pruritus is a hallmark of atopic dermatitis and is believed to be a signal of danger from various environmental factors or physiological abnormalities. While histamine is a well-known substance inducing itch, H-1-antihistamines may not be fully effective against intractable itch in patients with atopic dermatitis. Treatment of the underlying conditions that cause itch is necessary to improve the quality of life of patients with atopic dermatitis.
Article
Dermatology
Liu Tang, Jiefang Gao, Xiaoqin Cao, Lu Chen, Huiling Wang, Hong Ding
Summary: This study demonstrated that cutting off nails or using TRPV1 antagonist, ruthenium red, could alleviate symptoms of atopic dermatitis in mice by reducing clinical severity of dermatitis, IgE and Th2-related cytokine levels, as well as mast cell degranulation. Additionally, scratching behavior, levels of pruritogenic mediators, skin pH and TEWL were significantly decreased, suggesting a reduction in itch-associated scratching and skin barrier defects. The antipruritic effect of nail clipping or RR may be explained by the suppression of TRPV1 activation. These findings indicate the potential of targeting TRPV1 as a therapeutic approach in atopic dermatitis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Tiphaine Voisin, Caroline Perner, Marie-Angele Messou, Stephanie Shiers, Saltanat Ualiyeva, Yoshihide Kanaoka, Theodore J. Price, Caroline L. Sokol, Lora G. Bankova, K. Frank Austen, Isaac M. Chiu
Summary: This study uncovered the role of LTC4 and its receptor CysLT(2)R in inducing itch, providing a promising approach for treating inflammatory itch. The research highlights the importance of targeting CysLT signaling in managing inflammatory itch.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Seon Gyeong Bak, Hyung Jin Lim, Yeong-Seon Won, Eun Jae Park, Young Hee Kim, Seung Woong Lee, Je Hun Oh, Ji Eun Kim, Min Jee Lee, Soyoung Lee, Seung Jae Lee, Mun Chual Rho
Summary: This study investigated the therapeutic effect of Ampelopsis brevipedunculata extract on atopic dermatitis. It was found that the extract inhibited the expression of cytokines and chemokines, leading to reduced inflammation. These findings suggest that Ampelopsis brevipedunculata extract could be used to enhance skin immunity and promote skin health and beauty.
FOOD SCIENCE & NUTRITION
(2023)
Review
Dermatology
Thomas Luger, Masayuki Amagai, Brigitte Dreno, Marie-Ange Dagnelie, Wilson Liao, Kenji Kabashima, Tamara Schikowski, Ehrhardt Proksch, Peter M. Elias, Michel Simon, Eric Simpson, Erin Grinich, Matthias Schmuth
Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Hye-Jin Ahn, Min Kyung Shin
Summary: This study objectively measured transepidermal water loss (TEWL) and skin tone improvements after dupilumab treatment in nonlesional areas through bioengineering devices. The results showed significant improvement in TEWL and skin tone parameters in all anatomical regions.
DERMATOLOGIC THERAPY
(2023)
Review
Immunology
Risa Tamagawa-Mineoka
Summary: The skin acts as a physical barrier and toll-like receptors (TLRs) play a role in both infectious and non-infectious inflammatory diseases. In atopic dermatitis (AD), skin barrier dysfunction allows stimuli to penetrate the skin and activate the innate immune system, leading to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Cell Biology
Masanori Fujii
Summary: Ceramide abnormalities in atopic dermatitis (AD) are believed to be part of the disease's pathogenesis, with the involvement of Th2 and Th1 cytokines. Emollients rich in ceramides have been approved as adjunctive barrier repair agents for AD.
Review
Biochemistry & Molecular Biology
Lai-San Wong, Yu-Ta Yen, Chih-Hung Lee
Summary: Atopic dermatitis is a prototypic inflammatory disease characterized by intense itching, with multifactorial pathophysiology involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. Recent research has shown that pruritogens not only trigger itch but also interact with immune cells and act as inflammatory mediators, worsening the severity of atopic dermatitis. Targeted therapies for atopic dermatitis focus on the interaction between pruritogens and inflammatory molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Ania Stolarczyk, Nelissa Perez-Nazario, Sara A. Knowlden, Ellen Chinchilli, Alex Grier, Amy Paller, Steven R. Gill, Anna De Benedetto, Takeshi Yoshida, Lisa A. Beck
Summary: Studies have shown that bleach baths can improve the severity and itchiness of atopic dermatitis (AD) while also improving sleep quality. Bleach baths also have positive effects on skin barrier function. However, the effects on the abundance of Staphylococcus aureus and the diversity of skin microbes are not significant.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Monika Kopecna, Andrej Kovacik, Petr Novak, Mila Boncheva Bettex, Katerina Vavrova
Summary: Topical pain relief products containing diclofenac and etofenamate showed differences in drug transit through the skin barrier, skin retention, and potency. The Index of Relative Topical Antiinflammatory Activity (IRTAA) revealed significantly higher bioactivity and drug reservoir potential for diclofenac gel compared to etofenamate gels, suggesting superior efficacy in transdermal delivery.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Dermatology
Anna Novackova, Irene Sagrafena, Petra Pullmannova, Georgios Paraskevopoulos, Anupma Dwivedi, Anisha Mazumder, Karolina Ruzickova, Petr Slepicka, Jarmila Zbytovska, Katerina Vavrova
Summary: The text discusses the importance of lipid membrane remodeling in the body, focusing on skin barrier lipids and their role in maintaining a multilamellar nanostructure. Research suggests that the skin acid mantle may be a prerequisite for the multilamellar assembly of skin barrier lipids. Changes in lipid nanostructure and increased water loss were observed at neutral pH compared to acidic pH.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrej Kovacik, Petra Pullmannova, Lukas Opalka, Michaela Silarova, Jaroslav Maixner, Katerina Vavrova
Summary: The study shows that different types of ceramides play distinct roles in the structural organization and function of the skin lipid barrier, with their effects on lipid models varying depending on the sphingoid base chain and configuration at the alpha-carbon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Michaela Sochorova, Katerina Vavrova, Maria Fedorova, Zhixu Ni, Denise Slenter, Martina Kutmon, Egon L. Willighagen, Sophia Letsiou, Daniel Torocsik, Martina Marchetti-Deschmann, Samuele Zoratto, Christopher Kremslehner, Florian Gruber
Summary: Lipids play crucial roles in maintaining the epidermal barrier, regulating skin physical properties, and defending against microbes in the skin. The complexity of lipidomics analysis is comparable to that of proteomics, and recent technological advancements have enabled researchers to better understand the specific roles of lipid species in skin biology.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Editorial Material
Dermatology
Irene Sagrafena, Georgios Paraskevopoulos, Petra Pullmannova, Lukas Opalka, Anna Novackova, Ourania Lourantou, Katerina Vavrova
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ferdinand Fandrei, Oskar Engberg, Lukas Opalka, Pavla Jancalkova, Petra Pullmannova, Milos Steinhart, Andrej Kovacik, Katerina Vavrova, Daniel Huster
Summary: This study investigates the influence of the CholS/Chol ratio on the structure, dynamics, and permeability of SC lipid model mixtures. The results show that a high CholS/Chol ratio fluidizes the sterol fraction and increases the permeability of the SC lipid phase while maintaining the lamellar lipid arrangement with an asymmetric sterol distribution.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Dermatology
Kristyna Hergesell, Katerina Valentova, Vladimir Velebny, Katerina Vavrova, Iva Doleckova
Summary: This study evaluated the ability of common cosmetic and dermatological ingredients to prevent skin damage caused by air pollution. The results showed that these ingredients could effectively protect the skin from the negative effects of air pollution.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukas Opalka, Jason M. Meyer, Veronika Ondrejcekova, Linda Svatosova, Franz P. W. Radner, Katerina Vavrova
Summary: This study explored the importance of the linoleate moiety in epidermal omega-O-acylceramides (omega-O-acylCers) in the assembly of the skin lipid barrier. The results showed that the linoleate moiety is essential for lamellar pairing in skin lipid structures, and omega-hydroxylated Cers (omega-OHCers) cannot substitute for omega-O-acylCers. These findings suggest that omega-O-acylCer supplementation may be a potential therapeutic option for patients with PNPLA1 deficiency.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pavlina Haskova, Lenka Applova, Hana Jansova, Pavel Homola, Katherine J. Franz, Katerina Vavrova, Jaroslav Roh, Tomas Simunek
Summary: Labile redox-active iron ions have been implicated in various neurodegenerative disorders, and this study found that iron chelators, especially SIH and BSIH, showed promising neuroprotective potential against catecholamine oxidation and toxicity in differentiated PC12 cells.
SCIENTIFIC REPORTS
(2022)
Letter
Dermatology
Jason M. Meyer, Katerina Vavrova, Franz P. W. Radner, Holm Schneider, Angela Dick, Theodora M. Mauro, Peter M. Elias
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Monika Kopecna, Miloslav Machacek, Jaroslav Roh, Katerina Vavrova
Summary: The study synthesized three series of potential skin permeation enhancers, among which dodecyl prolinates derived from proline showed the strongest enhancing effect on theophylline and diclofenac, with low toxicity and reversible action.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Petra Pullmannova, Barbora A. Curikova-Kindlova, Veronika Ondrejcekova, Andrej Kovacik, Kristyna Dvorakova, Lucia Dulanska, Robert Georgii, Adam Majcher, Jaroslav Maixner, Norbert Kucerka, Jarmila Zbytovska, Katerina Vavrova
Summary: Ceramides are important cellular and extracellular lipids with a wide range of physiological functions. In the skin, they play a crucial role in the permeability barrier. The structure of ceramides is influenced by external conditions and directly affects the barrier properties.
Article
Biochemistry & Molecular Biology
Michaela Sochorova, Christopher Kremslehner, Ionela-Mariana Nagelreiter, Francesca Ferrara, Maja Mitrovic Lisicin, Marie-Sophie Narzt, Christina Bauer, Alexandra Stiegler, Bahar Golabi, Katerina Vavrova, Florian Gruber
Summary: NRF2 serves as a critical regulator in protecting cells from oxidative damage and plays a role in the aging process and epidermal differentiation of mammalian skin. In the absence of extrinsic stressors, NRF2-deficient mice do not exhibit obvious skin phenotype even at old age. However, the aged NRF2-deficient mice show disturbed epidermal differentiation and altered lipid composition, suggesting compensatory adaptations in keratinocyte proliferation and barrier lipid synthesis.
Article
Medicine, Research & Experimental
Andrej Kovacik, Monika Kopecna, Iva Hrdinova, Lukas Opalka, Mila Boncheva Bettex, Katerina Vavrova
Summary: Oleic acid and oleyl alcohol are commonly used permeation and penetration enhancers. Oleic acid promotes drug permeation through the skin more rapidly than oleyl alcohol but adversely affects skin barrier integrity, while oleyl alcohol has better drug retention in the skin compared to oleic acid.
MOLECULAR PHARMACEUTICS
(2023)
Meeting Abstract
Biophysics
Ferdinand Fandrei, Oskar Engberg, Albert Smith, Lukas Opalka, Andrej Kovacik, Katerina Vavrova, Daniel Huster
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2021)