Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 25, Issue 5, Pages 567-582Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543776.2015.1014802
Keywords
Alzheimer's disease; angiogenesis; antibody; apoptosis; cancer; laminin receptor precursor/laminin receptor; metastasis; small interfering RNA; therapy
Categories
Funding
- National Research Foundation (NRF)
- Republic of South Africa (RSA)
- South African Medical Research Council (SAMRC)
Ask authors/readers for more resources
Introduction: The 37/67 kDa high-affinity laminin receptor (laminin receptor precursor/laminin receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of various cancer types where it is seen to contribute to invasion, adhesion, apoptosis evasion and angiogenesis. Furthermore, it has been found to play an important role in facilitating the processes leading to neurotoxicity in Alzheimer's disease (AD). Various therapeutic options targeting this receptor have been patented with the outlook on application for the treatment/prevention of these diseases. Areas covered: The various roles that LRP/LR plays in cancer, AD and infectious diseases caused by viruses and bacteria have been examined in detail and an overview of the current patented therapeutic strategies targeting this receptor is given. Expert opinion: Molecular tools directed against LRP/LR, such as antibodies and small interfering RNA, could prove to be effective in the prevention of metastasis and angiogenesis while inducing apoptosis in cancers. Moreover, these strategies could also be applied to AD where LRP/LR is seen to facilitate the production and internalization of the neurotoxic Ab peptide. This review provides a comprehensive overview of the mechanisms by which LRP/LR is involved in eliciting pathogenic events, while showing how the use of patented approaches targeting this receptor could be used to treat them.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available