Pharmacotherapeutic options for treating adverse effects of Cisplatin chemotherapy

Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial

(2015) Lee S Schwartzberg et al.   LANCET ONCOLOGY

Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials

(2015) Bernardo L Rapoport et al.   LANCET ONCOLOGY

Immunohistochemical localization of OCT2 in the cochlea of various species

(2015) Victoria Hellberg et al.   LARYNGOSCOPE

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

(2015) Heng Xu et al.   NATURE GENETICS

Platinum-Induced Neurotoxicity and Preventive Strategies: Past, Present, and Future

(2015) A. Avan et al.   ONCOLOGIST

Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity

(2015) Claudia Lanvers-Kaminsky et al.   PHARMACOGENOMICS

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

(2015) Ja-Won Koo et al.   Science Translational Medicine

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity

(2015) Takatoshi Karasawa et al.   TOXICOLOGY LETTERS

Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study

(2014) P. J. Hesketh et al.   ANNALS OF ONCOLOGY

Cisplatin exposure damages resident stem cells of the mammalian inner Ear

(2014) Eric L. Slattery et al.   DEVELOPMENTAL DYNAMICS

Risk Factors for Cisplatin-Induced Nephrotoxicity and Potential of Magnesium Supplementation for Renal Protection

(2014) Yasuhiro Kidera et al.   PLoS One

Mechanisms of Epithelial Repair and Regeneration After Acute Kidney Injury

(2014) Katja Berger et al.   SEMINARS IN NEPHROLOGY

Conjunctive Therapy of Cisplatin With the OCT2 Inhibitor Cimetidine: Influence on Antitumor Efficacy and Systemic Clearance

(2013) J A Sprowl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DNA damage response in peripheral nervous system: Coping with cancer therapy-induced DNA lesions

(2013) Ella W. Englander   DNA REPAIR

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy

(2013) Ellen M. Lavoie Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sound preconditioning therapy inhibits ototoxic hearing loss in mice

(2013) Soumen Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity

(2013) S. S. More et al.   JOURNAL OF NEUROSCIENCE

Functional Mechanotransduction Is Required for Cisplatin-Induced Hair Cell Death in the Zebrafish Lateral Line

(2013) A. J. Thomas et al.   JOURNAL OF NEUROSCIENCE

Klotho has dual protective effects on cisplatin-induced acute kidney injury

(2013) Monica C. Panesso et al.   KIDNEY INTERNATIONAL

Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death

(2013) Andrew A. Vu et al.   PLoS One

Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale

(2012) Penelope R. Brock et al.   JOURNAL OF CLINICAL ONCOLOGY

Carboplatin- or Cisplatin-Based Chemotherapy in First-Line Treatment of Small-Cell Lung Cancer: The COCIS Meta-Analysis of Individual Patient Data

(2012) Antonio Rossi et al.   JOURNAL OF CLINICAL ONCOLOGY

Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention

(2012) W. Grisold et al.   NEURO-ONCOLOGY

Single-Dose Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting Associated With Cisplatin Therapy: Randomized, Double-Blind Study Protocol—EASE

(2011) Steven Grunberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Retinoic acid reduces chemotherapy-induced neuropathy in an animal model and patients with lung cancer

(2011) O. Arrieta et al.   NEUROLOGY

Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

(2011) Abdelrahman Alharazneh et al.   PLoS One

Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation

(2011) T Kaur et al.   Cell Death & Disease

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat

(2010) Debashree Mukherjea et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX3 NADPH Oxidase Couples Transient Receptor Potential Vanilloid 1 to Signal Transducer and Activator of Transcription 1-Mediated Inflammation and Hearing Loss

(2010) Debashree Mukherjea et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of Lipopolysaccharide-TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice

(2010) G.-S. Oh et al.   JOURNAL OF IMMUNOLOGY

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

(2010) H.-J. Kim et al.   JOURNAL OF NEUROSCIENCE

Vitamin E neuroprotection for cisplatin neuropathy: A randomized, placebo-controlled trial

(2010) A. Pace et al.   NEUROLOGY

NGF protects Dorsal Root Ganglion neurons from oxaliplatin by modulating JNK/Sapk and ERK1/2

(2010) Arianna Scuteri et al.   NEUROSCIENCE LETTERS

The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial

(2010) Lisa A. Kottschade et al.   SUPPORTIVE CARE IN CANCER

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cisplatin-Induced Hair Cell Death Requires STAT1 and Is Attenuated by Epigallocatechin Gallate

(2009) N. C. Schmitt et al.   JOURNAL OF NEUROSCIENCE

Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial

(2009) Mitsue Saito et al.   LANCET ONCOLOGY

Platinum neurotoxicity pharmacogenetics

(2009) S. R. McWhinney et al.   MOLECULAR CANCER THERAPEUTICS

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

(2009) Colin J D Ross et al.   NATURE GENETICS

Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals

(2009) BC Carleton et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients

(2009) D Caronia et al.   PHARMACOGENOMICS JOURNAL

Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons

(2008) Y. Jiang et al.   CANCER RESEARCH

Short Interfering RNA against Transient Receptor Potential Vanilloid 1 Attenuates Cisplatin-Induced Hearing Loss in the Rat

(2008) D. Mukherjea et al.   JOURNAL OF NEUROSCIENCE