Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 19, Pages 5384-5388Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201801111
Keywords
annulation; carbonylation; late-stage modification; manganese; traceless directing groups
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Funding
- Alexander von Humboldt Foundation
- DFG (Gottfried-Wilhelm-Leibniz Prize)
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An inexpensive, nontoxic manganese catalyst enabled unprecedented redox-neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious-metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late-stage manipulations under racemization-free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.
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